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Age-related Macular Degeneration clinical trials
20 of 75 indexed Age-related Macular Degeneration trials are currently recruiting.
75 US clinical trials · 20 currently recruiting
Age-related Macular Degeneration is the subject of 75 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is National Eye Institute (NEI), running 8 of these trials.
The research picture
Age-related Macular Degeneration has 75 registered US clinical trials, 20 of them open to new participants right now, about 27% of the total.
- 20
- recruiting participants now
- 27%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 8
- top sponsor: National Eye Institute (NEI)
Active & Recent Trials
75 total, page 2 of 2
Genetic Load and Phenotype in Aggressive AMD
Sequenom
NCT01650948
Microcurrent Stimulation Therapy for Nonexudative Age-related Macular Degeneration (i-SIGHT)
i-Lumen Scientific
NCT05447650
Study Evaluating Intravitreal hI-con1™ in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration
Iconic Therapeutics
NCT02358889
Cirrus HD-OCT Measurement of Area of Increased Light Penetration Under the Retinal Pigment Epithelium (RPE)
Carl Zeiss Meditec
NCT01272076
Evaluation of a New Eye-specific Multivitamin Formula in Participants at Risk of Age-related Macular Degeneration (AMD)
Guardion Health Sciences
NCT03946085
The Role of Loteprednol in Reducing Post-Intravitreal Injection Related Pain
Virginia Polytechnic Institute and State University
NCT05542381
Triple Therapy - PDT Plus IVD and Intravitreal Ranibizumab Versus Lucentis Monotherapy to Treat Age-Related Macular Degeneration
Bay Area Retina Associates
NCT00390208
A Study to Evaluate the Safety and Efficacy of RQC for AMD
Paul A Knepper, MD PhD
NCT05062486
Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study
National Eye Institute (NEI)
NCT01915238
30g vs 33g Needle for Intravitreal Injections
Wills Eye
NCT03038048
Safety and Exploratory Efficacy Study of SF0166 in the Treatment of Neovascular Age-Related Macular Degeneration (AMD)
OcuTerra Therapeutics
NCT02914639
An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects With Intermediate Age-Related Macular Degeneration
Stealth BioTherapeutics
NCT02848313
The Focal Electro-Oculogram in Macular Disease
National Eye Institute (NEI)
NCT02225119
Topical Proparacaine Eye Drops to Improve the Experience of Patients Undergoing Intravitreal Injections
Mayo Clinic
NCT02951351
Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO
Optos
NCT01692938
Ocular Safety and Usability Study for FYB201 PFS
Formycon
NCT06708624
Ocular Safety and Usability Study for FYB203 PFS
Formycon
NCT06708637
Safety of Intravitreal POT-4 Therapy for Patients With Neovascular Age-Related Macular Degeneration (AMD)
Potentia Pharmaceuticals
NCT00473928
Study Evaluating Retinal Health Monitoring System Visual Acuity Module.
Kubota Vision
NCT04169802
Antibiotic Resistant Patterns of Conjunctival and Nasophayngeal Flora After Repeated Exposure to Topical Antibiotics
Vanderbilt University
NCT00831961
Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD
Novartis Pharmaceuticals
NCT03954626
Long Term Follow Up of Sub-retinal Transplantation of hESC Derived RPE Cells in Patients With AMD
Astellas Institute for Regenerative Medicine
NCT02463344
Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral GA Associated With AMD
National Eye Institute (NEI)
NCT00766649
RBM-007 in Subjects witH ExudatIve Age-related Macular Degeneration
Ribomic USA
NCT03633084
Early Feasibility Study Using IOPCL MAG to Improve Near Vision in ARMD Subjects
OnPoint Vision
NCT04984590
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 18 |
| Phase 2 | 8 |
| Phase 3 | 6 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Age-related Macular Degeneration Trial Landscape
75 indexed Age-related Macular Degeneration studies · 20 recruiting (27%).
Phase mix: 8 late (III/IV) vs 26 early (I/II).
Top sponsor: National Eye Institute (NEI) (8 trials), 9 others listed. 25 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Age-related Macular Degeneration?
PlainTrial tracks 75 US clinical trials for Age-related Macular Degeneration, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Age-related Macular Degeneration?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.