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ClinicalTrials.gov 20 recruiting now official registry

Age-related Macular Degeneration clinical trials

20 of 75 indexed Age-related Macular Degeneration trials are currently recruiting.

75 US clinical trials · 20 currently recruiting

Age-related Macular Degeneration is the subject of 75 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is National Eye Institute (NEI), running 8 of these trials.

The research picture

Age-related Macular Degeneration has 75 registered US clinical trials, 20 of them open to new participants right now, about 27% of the total.

20
recruiting participants now
27%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
8
top sponsor: National Eye Institute (NEI)
Phase 118Phase 28Phase 36Phase 42

Active & Recent Trials

75 total, page 2 of 2

COMPLETED 100 participants

Genetic Load and Phenotype in Aggressive AMD

Sequenom

NCT01650948

COMPLETED NA 95 participants

Microcurrent Stimulation Therapy for Nonexudative Age-related Macular Degeneration (i-SIGHT)

i-Lumen Scientific

NCT05447650

COMPLETED Phase 2 88 participants

Study Evaluating Intravitreal hI-con1™ in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration

Iconic Therapeutics

NCT02358889

COMPLETED 85 participants

Cirrus HD-OCT Measurement of Area of Increased Light Penetration Under the Retinal Pigment Epithelium (RPE)

Carl Zeiss Meditec

NCT01272076

COMPLETED NA 79 participants

Evaluation of a New Eye-specific Multivitamin Formula in Participants at Risk of Age-related Macular Degeneration (AMD)

Guardion Health Sciences

NCT03946085

COMPLETED NA 64 participants

The Role of Loteprednol in Reducing Post-Intravitreal Injection Related Pain

Virginia Polytechnic Institute and State University

NCT05542381

COMPLETED Phase 2 60 participants

Triple Therapy - PDT Plus IVD and Intravitreal Ranibizumab Versus Lucentis Monotherapy to Treat Age-Related Macular Degeneration

Bay Area Retina Associates

NCT00390208

COMPLETED Phase 2 55 participants

A Study to Evaluate the Safety and Efficacy of RQC for AMD

Paul A Knepper, MD PhD

NCT05062486

COMPLETED 52 participants

Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study

National Eye Institute (NEI)

NCT01915238

COMPLETED NA 50 participants

30g vs 33g Needle for Intravitreal Injections

Wills Eye

NCT03038048

COMPLETED Phase 1 44 participants

Safety and Exploratory Efficacy Study of SF0166 in the Treatment of Neovascular Age-Related Macular Degeneration (AMD)

OcuTerra Therapeutics

NCT02914639

COMPLETED Phase 1 40 participants

An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects With Intermediate Age-Related Macular Degeneration

Stealth BioTherapeutics

NCT02848313

COMPLETED 39 participants

The Focal Electro-Oculogram in Macular Disease

National Eye Institute (NEI)

NCT02225119

COMPLETED NA 36 participants

Topical Proparacaine Eye Drops to Improve the Experience of Patients Undergoing Intravitreal Injections

Mayo Clinic

NCT02951351

COMPLETED 32 participants

Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO

Optos

NCT01692938

COMPLETED Phase 4 31 participants

Ocular Safety and Usability Study for FYB201 PFS

Formycon

NCT06708624

COMPLETED Phase 4 30 participants

Ocular Safety and Usability Study for FYB203 PFS

Formycon

NCT06708637

COMPLETED Phase 1 27 participants

Safety of Intravitreal POT-4 Therapy for Patients With Neovascular Age-Related Macular Degeneration (AMD)

Potentia Pharmaceuticals

NCT00473928

COMPLETED 25 participants

Study Evaluating Retinal Health Monitoring System Visual Acuity Module.

Kubota Vision

NCT04169802

COMPLETED 24 participants

Antibiotic Resistant Patterns of Conjunctival and Nasophayngeal Flora After Repeated Exposure to Topical Antibiotics

Vanderbilt University

NCT00831961

COMPLETED Phase 3 14 participants

Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD

Novartis Pharmaceuticals

NCT03954626

COMPLETED 11 participants

Long Term Follow Up of Sub-retinal Transplantation of hESC Derived RPE Cells in Patients With AMD

Astellas Institute for Regenerative Medicine

NCT02463344

COMPLETED Phase 1 11 participants

Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral GA Associated With AMD

National Eye Institute (NEI)

NCT00766649

COMPLETED Phase 1 9 participants

RBM-007 in Subjects witH ExudatIve Age-related Macular Degeneration

Ribomic USA

NCT03633084

COMPLETED 9 participants

Early Feasibility Study Using IOPCL MAG to Improve Near Vision in ARMD Subjects

OnPoint Vision

NCT04984590

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Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 8
Phase 3 6
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Age-related Macular Degeneration Trial Landscape

75 indexed Age-related Macular Degeneration studies · 20 recruiting (27%).

Phase mix: 8 late (III/IV) vs 26 early (I/II).

Top sponsor: National Eye Institute (NEI) (8 trials), 9 others listed. 25 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Age-related Macular Degeneration?

PlainTrial tracks 75 US clinical trials for Age-related Macular Degeneration, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Age-related Macular Degeneration?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.