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Pulmonary Disease, Chronic Obstructive
Open-data reference.
75 US clinical trials · 7 currently recruiting
Active & Recent Trials
Pragmatic Trial to Enhance Quality Safety, and Patient Experience in COPD
Seattle Institute for Biomedical and Clinical Research
NCT05718102
eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation
GlaxoSmithKline
NCT07177339
Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA -1)
GlaxoSmithKline
NCT06959095
Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
GlaxoSmithKline
NCT06961214
A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
GlaxoSmithKline
NCT06154837
The ROAM Research Study Therapy (LTOT) Version
University of Virginia
NCT06810323
Trial to Determine Effective Aspirin Dose in COPD
Johns Hopkins University
NCT05265299
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)
Brigham and Women's Hospital
NCT00608764
Air Filtration for COPD in VA Population of Veterans
Illinois Institute of Technology
NCT05913765
Evaluating the Clinical Effectiveness of a Patient-specific Silicone Stent
VisionAir Solutions
NCT05050591
A Study Comparing the Efficacy, Safety and Tolerability of Fixed Dose Combination (FDC) of FF/UMEC/VI With the FDC of FF/VI and UMEC/VI; Administered Once-daily Via a Dry Powder Inhaler (DPI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
GlaxoSmithKline
NCT02164513
Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease.
Boehringer Ingelheim
NCT02296138
Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)
GlaxoSmithKline
NCT00268216
Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients
Boehringer Ingelheim
NCT00144339
EXACERBATIONS AND REAL-WORLD OUTOMES AMONG PATIENTS WITH COPD INITIATING BREZTRI (EROS+CP Japan Study)
AstraZeneca
NCT07103642
Tiotropium+Olodaterol Fixed Dose Combination (FDC) Versus Tiotropium and Olodaterol in Chronic Obstructive Pulmonary Disease (COPD)
Boehringer Ingelheim
NCT01431274
Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)
University of Washington
NCT04281784
A 24-week Evaluation of GSK573719/Vilanterol (125/25mcg) and Components in COPD
GlaxoSmithKline
NCT01313637
Evaluation of Lung Function and Symptoms in Patients Diagnosed With Chronic Obstructive Pulmonary Disease (COPD) on Long-Acting Bronchodilator Monotherapy
GlaxoSmithKline
NCT00791518
A 12-week Study to Evaluate the Efficacy and Safety of Umeclidinium Compared With Tiotropium in Subjects With Chronic Obstructive Pulmonary Disease
GlaxoSmithKline
NCT02207829
Tiotropium / Respimat One-Year Study
Boehringer Ingelheim
NCT00168831
Dose-range Finding Efficacy and Safety Study for QBW251 in COPD Patients
Novartis Pharmaceuticals
NCT04072887
24-week Trial Comparing GSK573719/GW642444 With GW642444 and With Tiotropium in Chronic Obstructive Pulmonary Disease
GlaxoSmithKline
NCT01316900
A Study to Assess the Efficacy of Fluticasone Furoate/Vilanterol (FF/VI) Inhalation Powder 100/25 mcg Once Daily Compared With Fluticasone Propionate/Salmeterol Inhalation Powder 250/50 mcg Twice Daily in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
GlaxoSmithKline
NCT01706328
Tiotropium+Olodaterol Fixed Dose Combination (FDC) in Chronic Obstructive Pulmonary Disease (OTEMTO 2)
Boehringer Ingelheim
NCT02006732
Advair® DISKUS® Versus Serevent® DISKUS® For Chronic Obstructive Pulmonary Disease Exacerbations
GlaxoSmithKline
NCT00115492
Study To Evaluate The Efficacy And Safety Of PH-797804 For 12 Weeks In Adults With Moderate To Severe Chronic Obstructive Pulmonary Disease (COPD) On A Background Of Tiotropium Bromide
Pfizer
NCT01543919
Chronic Obstructive Pulmonary Disease (COPD) Post-hospitalization Study
GlaxoSmithKline
NCT01110200
Efficacy and Safety of the Addition of Fluticanse Propionate/Salmeterol (250/50mcg) Twice-daily to 2 Doses of Umeclidinium Bromide (62.5 or 125mcg) Once-daily Over 12 Weeks
GlaxoSmithKline
NCT01772134
A Study To Assess Efficacy And Safety Of Different Doses Of GW642444 In Subjects With Chronic Obstructive Pulmonary Disease (COPD)
GlaxoSmithKline
NCT00606684
Dose-Ranging Study Of GSK233705B In Subjects With Chronic Obstructive Pulmonary Disease (COPD)
GlaxoSmithKline
NCT00676052
CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD
Punam K Saha
NCT03534934
Multidisciplinary Inpatient Palliative Care Intervention
Kaiser Permanente
NCT00325611
Study Evaluating the 24-Hour Pulmonary Function Profile of Fluticasone Furoate (FF) /GW642444 (Vilanterol) (VI) Inhalation Powder 100/25mcg Once Daily Compared With Fluticasone Propionate/Salmeterol Inhalation Powder 250/50mcg Twice Daily in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
GlaxoSmithKline
NCT01323621
Efficacy and Safety of 4 Weeks Treatment With Inhaled BI 1744 CL in Patients With COPD.
Boehringer Ingelheim
NCT00452400
A Study To Investigate The Safety, Toleration And Efficacy of PF00610355 In Chronic Obstructive Pulmonary Disease (COPD) Patients.
Pfizer
NCT00808288
Combination of Orally Inhaled BI1744CL/Tiotropium Bromide in Patients With Chronic Obstructive Pulmonary Disease ( COPD)
Boehringer Ingelheim
NCT00696020
Evaluation of Umeclidinium Bromide in Combination With Fluticasone Furoate in COPD Subjects With an Asthmatic Component
GlaxoSmithKline
NCT02164539
Trial Comparing Treatment With Tiotropium Inhalation Capsules to Combivent® Inhalation Aerosol in COPD Patients.
Boehringer Ingelheim
NCT00388882
An Exercise Endurance Study to Evaluate the Effects of Treatment of Chronic Obstructive Pulmonary Disease (COPD) Patients With a Dual Bronchodilator: GSK573719/GW642444.Study B
GlaxoSmithKline
NCT01323660
To Evaluate the Effect of Inhaled Medication Together With Exercise and Activity Training on Exercise Capacity and Daily Activities in Patients With Chronic Lung Disease With Obstruction of Airways
Boehringer Ingelheim
NCT02085161
Safety and Efficacy of Inhaled Insulin in Patients With Diabetes and Asthma or COPD
Eli Lilly and Company
NCT00157339
Effect on Exercise Endurance and Lung Hyperinflation of Tiotropium + Olodaterol in COPD Patients
Boehringer Ingelheim
NCT01533922
Efficacy and Safety of BCT197 in Subjects With Acute Respiratory Exacerbations of Chronic Obstructive Pulmonary Disease
Mereo BioPharma
NCT02700919
Ease of Use and Correct Use Study of Placebo ELLIPTA® Inhaler in COPD Subjects
GlaxoSmithKline
NCT02586493
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease
Washington University School of Medicine
NCT00725309
A 16-Week Study to Evaluate the Effect of Advair DISKUS™ 250/50mcg on Arterial Stiffness in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
GlaxoSmithKline
NCT00857766
Advair HFA For Chronic Obstructive Pulmonary Disease(COPD)
GlaxoSmithKline
NCT00633217
Comparative Study of ELLIPTA Dry Powder Inhaler (DPI) Versus DISKUS DPI Used With HandiHaler DPI in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
GlaxoSmithKline
NCT03227445
An Efficacy Study of Umeclidinium/Vilanterol With Tiotropium/Olodaterol in COPD Patients
GlaxoSmithKline
NCT02799784
A Cognitive-Behavioral Intervention for Depression and Anxiety in COPD
US Department of Veterans Affairs
NCT00105911
Bone Mineral Density Study In Patients With Chronic Obstructive Pulmonary Disease. DISKUS® Inhaler is a Trademark of the GSK Group of Companies.
GlaxoSmithKline
NCT00355342
Outlook: An Intervention to Improve Quality of Life in Serious Illness
Duke University
NCT00939146
A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD
Abgenix
NCT00035828
Efficacy and Safety Comparison of Tiotropium Inhalation Solution (Respimat Inhaler) and Spiriva HandiHaler in COPD
Boehringer Ingelheim
NCT00239447
Problem-Solving Therapy for People With Major Depression and Chronic Obstructive Pulmonary Disease
Weill Medical College of Cornell University
NCT00601055
A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).
Centocor
NCT00380796
Investigate the Impact of Early Treatment Initiation With Tiotropium in Patients Recovering From Hospitalization for an Acute COPD Exacerbation 2
Boehringer Ingelheim
NCT01662986
Safety and Tolerability of Repeat Dosing of GSK233705/GW642444 in COPD
GlaxoSmithKline
NCT00749411
Pharmacokinetic Study in Healthy Volunteers to Characterise the Exposure of Fluticasone Furoate (FF), Vilanterol (VI) and Umeclidinium (UMEC) at Two Different Doses
GlaxoSmithKline
NCT01894386
Association Between Increased Oxidative Stress, Anti-Inflammatory Fatty Acid Formation, and Airway Infection in People With Asthma and Chronic Obstructive Pulmonary Disease
Brigham and Women's Hospital
NCT00595114
Changes in Cytokine Levels During an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
University of Michigan
NCT00281242
Peripheral Nerve Blocks for Above-the-knee Amputations
University of Florida
NCT03404180
A Study to Investigate the Safety and Pharmacokinetics of a Single Dose of GSK2256294 in Healthy Young Males and Elderly Subjects
GlaxoSmithKline
NCT02006537
Transforming Psychotherapy for Chronically Ill Patients
US Department of Veterans Affairs
NCT00520429
Cathelicidin and Vitamin D: Impact on Populations At-Risk and With COPD
University of North Carolina, Chapel Hill
NCT02464059
Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK2269557 Administered Via the ELLIPTA Dry Powder Inhaler to Healthy Subjects
GlaxoSmithKline
NCT02691325
Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD
VA Greater Los Angeles Healthcare System
NCT03370835
The Trajectory of Physical Activity Following Pulmonary Rehabilitation
Trinity Health Of New England
NCT02399254
A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics (PK) of Nemiralisib
GlaxoSmithKline
NCT03398421
Real-Time Support for Exercise Persistence in COPD
University of Washington
NCT00373932
Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest
Johns Hopkins University
NCT04170062
Abdominal Functional Electrical Stimulation to Reduce Hyperinflation in Chronic Obstructive Pulmonary Disease Patients
Liberate Medical
NCT02035228
Home COPD and Open Ventilation Evaluation (HOPE) Study
Landon Pediatric Foundation
NCT03691181
Proof of Concept Study Assessing Technology-Assisted Respiratory Adherence Prototype Version 3 in Individuals With COPD
Boehringer Ingelheim
NCT04795323
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 7 |
| Phase 2 | 13 |
| Phase 3 | 22 |
| Phase 4 | 12 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Pulmonary Disease, Chronic Obstructive Trial Landscape
ClinicalTrials.gov lists 75 US studies indexed under Pulmonary Disease, Chronic Obstructive, and 7 of those are currently open to recruitment — roughly 9% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Pulmonary Disease, Chronic Obstructive shows 34 late-stage studies (Phase 3 and Phase 4 combined) alongside 20 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Pulmonary Disease, Chronic Obstructive is led by GlaxoSmithKline with 30 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 75 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Pulmonary Disease, Chronic Obstructive?
PlainTrial tracks 75 US clinical trials for Pulmonary Disease, Chronic Obstructive, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Pulmonary Disease, Chronic Obstructive?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.