Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Pulmonary Disease, Chronic Obstructive

Open-data reference.

75 US clinical trials · 7 currently recruiting

Active & Recent Trials

RECRUITING NA 4,000 participants

Pragmatic Trial to Enhance Quality Safety, and Patient Experience in COPD

Seattle Institute for Biomedical and Clinical Research

NCT05718102

RECRUITING Phase 3 1,196 participants

eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation

GlaxoSmithKline

NCT07177339

RECRUITING Phase 3 981 participants

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA -1)

GlaxoSmithKline

NCT06959095

RECRUITING Phase 3 960 participants

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

GlaxoSmithKline

NCT06961214

RECRUITING Phase 1 130 participants

A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease

GlaxoSmithKline

NCT06154837

RECRUITING 100 participants

The ROAM Research Study Therapy (LTOT) Version

University of Virginia

NCT06810323

RECRUITING Phase 3 48 participants

Trial to Determine Effective Aspirin Dose in COPD

Johns Hopkins University

NCT05265299

ACTIVE NOT RECRUITING 10,718 participants

Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)

Brigham and Women's Hospital

NCT00608764

ACTIVE NOT RECRUITING NA 80 participants

Air Filtration for COPD in VA Population of Veterans

Illinois Institute of Technology

NCT05913765

ACTIVE NOT RECRUITING NA 20 participants

Evaluating the Clinical Effectiveness of a Patient-specific Silicone Stent

VisionAir Solutions

NCT05050591

COMPLETED Phase 3 10,355 participants

A Study Comparing the Efficacy, Safety and Tolerability of Fixed Dose Combination (FDC) of FF/UMEC/VI With the FDC of FF/VI and UMEC/VI; Administered Once-daily Via a Dry Powder Inhaler (DPI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT02164513

COMPLETED Phase 3 7,903 participants

Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease.

Boehringer Ingelheim

NCT02296138

COMPLETED Phase 3 6,228 participants

Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT00268216

COMPLETED Phase 3 5,993 participants

Evaluation of the Long- Term Effects of Spiriva on Lung Function in COPD Patients

Boehringer Ingelheim

NCT00144339

COMPLETED 3,402 participants

EXACERBATIONS AND REAL-WORLD OUTOMES AMONG PATIENTS WITH COPD INITIATING BREZTRI (EROS+CP Japan Study)

AstraZeneca

NCT07103642

COMPLETED Phase 3 2,624 participants

Tiotropium+Olodaterol Fixed Dose Combination (FDC) Versus Tiotropium and Olodaterol in Chronic Obstructive Pulmonary Disease (COPD)

Boehringer Ingelheim

NCT01431274

COMPLETED NA 2,512 participants

Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)

University of Washington

NCT04281784

COMPLETED Phase 3 1,493 participants

A 24-week Evaluation of GSK573719/Vilanterol (125/25mcg) and Components in COPD

GlaxoSmithKline

NCT01313637

COMPLETED 1,084 participants

Evaluation of Lung Function and Symptoms in Patients Diagnosed With Chronic Obstructive Pulmonary Disease (COPD) on Long-Acting Bronchodilator Monotherapy

GlaxoSmithKline

NCT00791518

COMPLETED Phase 3 1,017 participants

A 12-week Study to Evaluate the Efficacy and Safety of Umeclidinium Compared With Tiotropium in Subjects With Chronic Obstructive Pulmonary Disease

GlaxoSmithKline

NCT02207829

COMPLETED Phase 3 1,007 participants

Tiotropium / Respimat One-Year Study

Boehringer Ingelheim

NCT00168831

COMPLETED Phase 2 974 participants

Dose-range Finding Efficacy and Safety Study for QBW251 in COPD Patients

Novartis Pharmaceuticals

NCT04072887

COMPLETED Phase 3 846 participants

24-week Trial Comparing GSK573719/GW642444 With GW642444 and With Tiotropium in Chronic Obstructive Pulmonary Disease

GlaxoSmithKline

NCT01316900

COMPLETED Phase 3 828 participants

A Study to Assess the Efficacy of Fluticasone Furoate/Vilanterol (FF/VI) Inhalation Powder 100/25 mcg Once Daily Compared With Fluticasone Propionate/Salmeterol Inhalation Powder 250/50 mcg Twice Daily in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT01706328

COMPLETED Phase 3 809 participants

Tiotropium+Olodaterol Fixed Dose Combination (FDC) in Chronic Obstructive Pulmonary Disease (OTEMTO 2)

Boehringer Ingelheim

NCT02006732

COMPLETED Phase 4 797 participants

Advair® DISKUS® Versus Serevent® DISKUS® For Chronic Obstructive Pulmonary Disease Exacerbations

GlaxoSmithKline

NCT00115492

COMPLETED Phase 2 730 participants

Study To Evaluate The Efficacy And Safety Of PH-797804 For 12 Weeks In Adults With Moderate To Severe Chronic Obstructive Pulmonary Disease (COPD) On A Background Of Tiotropium Bromide

Pfizer

NCT01543919

COMPLETED Phase 4 639 participants

Chronic Obstructive Pulmonary Disease (COPD) Post-hospitalization Study

GlaxoSmithKline

NCT01110200

COMPLETED Phase 3 617 participants

Efficacy and Safety of the Addition of Fluticanse Propionate/Salmeterol (250/50mcg) Twice-daily to 2 Doses of Umeclidinium Bromide (62.5 or 125mcg) Once-daily Over 12 Weeks

GlaxoSmithKline

NCT01772134

COMPLETED Phase 2 602 participants

A Study To Assess Efficacy And Safety Of Different Doses Of GW642444 In Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT00606684

COMPLETED Phase 2 576 participants

Dose-Ranging Study Of GSK233705B In Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT00676052

COMPLETED NA 560 participants

CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD

Punam K Saha

NCT03534934

COMPLETED NA 550 participants

Multidisciplinary Inpatient Palliative Care Intervention

Kaiser Permanente

NCT00325611

COMPLETED Phase 3 512 participants

Study Evaluating the 24-Hour Pulmonary Function Profile of Fluticasone Furoate (FF) /GW642444 (Vilanterol) (VI) Inhalation Powder 100/25mcg Once Daily Compared With Fluticasone Propionate/Salmeterol Inhalation Powder 250/50mcg Twice Daily in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT01323621

COMPLETED Phase 2 409 participants

Efficacy and Safety of 4 Weeks Treatment With Inhaled BI 1744 CL in Patients With COPD.

Boehringer Ingelheim

NCT00452400

COMPLETED Phase 2 405 participants

A Study To Investigate The Safety, Toleration And Efficacy of PF00610355 In Chronic Obstructive Pulmonary Disease (COPD) Patients.

Pfizer

NCT00808288

COMPLETED Phase 2 360 participants

Combination of Orally Inhaled BI1744CL/Tiotropium Bromide in Patients With Chronic Obstructive Pulmonary Disease ( COPD)

Boehringer Ingelheim

NCT00696020

COMPLETED Phase 2 338 participants

Evaluation of Umeclidinium Bromide in Combination With Fluticasone Furoate in COPD Subjects With an Asthmatic Component

GlaxoSmithKline

NCT02164539

COMPLETED Phase 4 327 participants

Trial Comparing Treatment With Tiotropium Inhalation Capsules to Combivent® Inhalation Aerosol in COPD Patients.

Boehringer Ingelheim

NCT00388882

COMPLETED Phase 3 307 participants

An Exercise Endurance Study to Evaluate the Effects of Treatment of Chronic Obstructive Pulmonary Disease (COPD) Patients With a Dual Bronchodilator: GSK573719/GW642444.Study B

GlaxoSmithKline

NCT01323660

COMPLETED Phase 3 304 participants

To Evaluate the Effect of Inhaled Medication Together With Exercise and Activity Training on Exercise Capacity and Daily Activities in Patients With Chronic Lung Disease With Obstruction of Airways

Boehringer Ingelheim

NCT02085161

COMPLETED Phase 3 299 participants

Safety and Efficacy of Inhaled Insulin in Patients With Diabetes and Asthma or COPD

Eli Lilly and Company

NCT00157339

COMPLETED Phase 3 295 participants

Effect on Exercise Endurance and Lung Hyperinflation of Tiotropium + Olodaterol in COPD Patients

Boehringer Ingelheim

NCT01533922

COMPLETED Phase 2 282 participants

Efficacy and Safety of BCT197 in Subjects With Acute Respiratory Exacerbations of Chronic Obstructive Pulmonary Disease

Mereo BioPharma

NCT02700919

COMPLETED Phase 4 278 participants

Ease of Use and Correct Use Study of Placebo ELLIPTA® Inhaler in COPD Subjects

GlaxoSmithKline

NCT02586493

COMPLETED 255 participants

Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease

Washington University School of Medicine

NCT00725309

COMPLETED Phase 4 249 participants

A 16-Week Study to Evaluate the Effect of Advair DISKUS™ 250/50mcg on Arterial Stiffness in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT00857766

COMPLETED Phase 4 247 participants

Advair HFA For Chronic Obstructive Pulmonary Disease(COPD)

GlaxoSmithKline

NCT00633217

COMPLETED Phase 4 240 participants

Comparative Study of ELLIPTA Dry Powder Inhaler (DPI) Versus DISKUS DPI Used With HandiHaler DPI in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03227445

COMPLETED Phase 4 236 participants

An Efficacy Study of Umeclidinium/Vilanterol With Tiotropium/Olodaterol in COPD Patients

GlaxoSmithKline

NCT02799784

COMPLETED NA 222 participants

A Cognitive-Behavioral Intervention for Depression and Anxiety in COPD

US Department of Veterans Affairs

NCT00105911

COMPLETED Phase 4 186 participants

Bone Mineral Density Study In Patients With Chronic Obstructive Pulmonary Disease. DISKUS® Inhaler is a Trademark of the GSK Group of Companies.

GlaxoSmithKline

NCT00355342

COMPLETED NA 154 participants

Outlook: An Intervention to Improve Quality of Life in Serious Illness

Duke University

NCT00939146

COMPLETED Phase 2 150 participants

A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD

Abgenix

NCT00035828

COMPLETED Phase 3 131 participants

Efficacy and Safety Comparison of Tiotropium Inhalation Solution (Respimat Inhaler) and Spiriva HandiHaler in COPD

Boehringer Ingelheim

NCT00239447

COMPLETED NA 101 participants

Problem-Solving Therapy for People With Major Depression and Chronic Obstructive Pulmonary Disease

Weill Medical College of Cornell University

NCT00601055

COMPLETED 88 participants

A Long-term Safety Study of Infliximab in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).

Centocor

NCT00380796

COMPLETED Phase 4 79 participants

Investigate the Impact of Early Treatment Initiation With Tiotropium in Patients Recovering From Hospitalization for an Acute COPD Exacerbation 2

Boehringer Ingelheim

NCT01662986

COMPLETED Phase 2 61 participants

Safety and Tolerability of Repeat Dosing of GSK233705/GW642444 in COPD

GlaxoSmithKline

NCT00749411

COMPLETED Phase 1 48 participants

Pharmacokinetic Study in Healthy Volunteers to Characterise the Exposure of Fluticasone Furoate (FF), Vilanterol (VI) and Umeclidinium (UMEC) at Two Different Doses

GlaxoSmithKline

NCT01894386

COMPLETED 43 participants

Association Between Increased Oxidative Stress, Anti-Inflammatory Fatty Acid Formation, and Airway Infection in People With Asthma and Chronic Obstructive Pulmonary Disease

Brigham and Women's Hospital

NCT00595114

COMPLETED 37 participants

Changes in Cytokine Levels During an Acute Exacerbation of Chronic Obstructive Pulmonary Disease

University of Michigan

NCT00281242

COMPLETED Phase 4 30 participants

Peripheral Nerve Blocks for Above-the-knee Amputations

University of Florida

NCT03404180

COMPLETED Phase 1 28 participants

A Study to Investigate the Safety and Pharmacokinetics of a Single Dose of GSK2256294 in Healthy Young Males and Elderly Subjects

GlaxoSmithKline

NCT02006537

COMPLETED Phase 1 23 participants

Transforming Psychotherapy for Chronically Ill Patients

US Department of Veterans Affairs

NCT00520429

COMPLETED Phase 2 23 participants

Cathelicidin and Vitamin D: Impact on Populations At-Risk and With COPD

University of North Carolina, Chapel Hill

NCT02464059

COMPLETED Phase 1 22 participants

Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK2269557 Administered Via the ELLIPTA Dry Powder Inhaler to Healthy Subjects

GlaxoSmithKline

NCT02691325

COMPLETED Phase 4 21 participants

Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD

VA Greater Los Angeles Healthcare System

NCT03370835

COMPLETED 21 participants

The Trajectory of Physical Activity Following Pulmonary Rehabilitation

Trinity Health Of New England

NCT02399254

COMPLETED Phase 1 20 participants

A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics (PK) of Nemiralisib

GlaxoSmithKline

NCT03398421

COMPLETED Phase 1 17 participants

Real-Time Support for Exercise Persistence in COPD

University of Washington

NCT00373932

COMPLETED NA 11 participants

Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest

Johns Hopkins University

NCT04170062

COMPLETED NA 7 participants

Abdominal Functional Electrical Stimulation to Reduce Hyperinflation in Chronic Obstructive Pulmonary Disease Patients

Liberate Medical

NCT02035228

COMPLETED NA 6 participants

Home COPD and Open Ventilation Evaluation (HOPE) Study

Landon Pediatric Foundation

NCT03691181

COMPLETED Phase 2 5 participants

Proof of Concept Study Assessing Technology-Assisted Respiratory Adherence Prototype Version 3 in Individuals With COPD

Boehringer Ingelheim

NCT04795323

Phase Distribution

PhaseTrial count
Early Phase 1 7
Phase 2 13
Phase 3 22
Phase 4 12

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pulmonary Disease, Chronic Obstructive Trial Landscape

ClinicalTrials.gov lists 75 US studies indexed under Pulmonary Disease, Chronic Obstructive, and 7 of those are currently open to recruitment — roughly 9% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Pulmonary Disease, Chronic Obstructive shows 34 late-stage studies (Phase 3 and Phase 4 combined) alongside 20 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Pulmonary Disease, Chronic Obstructive is led by GlaxoSmithKline with 30 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 75 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pulmonary Disease, Chronic Obstructive?

PlainTrial tracks 75 US clinical trials for Pulmonary Disease, Chronic Obstructive, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pulmonary Disease, Chronic Obstructive?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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