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NCT06825858 · ClinicalTrials.gov registry record · Phase 1
A Phase I, Open-label, Multicenter, Dose-Escalating Study to Evaluate the Safety and Tolerability of KH658 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration
A Phase 1 study of Age-related Macular Degeneration, sponsored by Chengdu Origen Biotechnology Co..
- Active
- Registry status
- Phase 1
- Development phase
- 9
- Enrollment target
- 3
- Study locations
NCT06825858: Active Phase 1 study of Age-related Macular Degeneration, sponsored by Chengdu Origen Biotechnology Co..
NCT06825858 is a Phase 1 study of Age-related Macular Degeneration that is active but no longer recruiting, run by Chengdu Origen Biotechnology Co.. The registered enrollment target is 9 participants, below the 1,508-participant average among 74 other Age-related Macular Degeneration trials with a reported enrollment target (99% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06825858, a Phase 1 study of Age-related Macular Degeneration, is active but no longer recruiting, sponsored by Chengdu Origen Biotechnology Co..
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 9 participants
- Enrollment target
- 3
- Study locations
Study Summary
VAN-2401 is Phase I clinical trial to assess the safety and tolerability of KH658 in subjects with neovascular AMD. KH658 is gene therapy designed to deliver a protein which targets and blocks VEGF via an adeno-associated viral vector. The standard of care for patients with neovascular AMD are anti-VEGF treaments, which have demonstrated improvement in vision and reduction in fluid. A one time placement of a product which inhibits VEGF has the potential to reduce the patient burden of regular ocular injections.
Primary Outcome
type, severity and incidence of ocular and systemic AEs and SAEs
Conditions Studied
Interventions
- DRUG KH658
Study Locations (3)
Arizona
- Kanghong Investigative Site - Phoenix
Illinois
- Kanghong Investigative Site - Lemont
Tennessee
- Kanghong Investigative Site - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2025-04-07 |
| Est. Completion | 2027-03 |
| Phase | Phase 1 |
What the registry record for NCT06825858 still lists
NCT06825858 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 1,508-participant average among 74 other Age-related Macular Degeneration trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Age-related Macular Degeneration appearing as the primary indexed condition, and to 1 intervention - of which KH658 is the first listed.
NCT06825858 reports a single indexed study location in Arizona, Illinois, Tennessee.
Frequently Asked Questions
What is clinical trial NCT06825858 about?
NCT06825858 is a clinical study titled "A Phase I, Open-label, Multicenter, Dose-Escalating Study to Evaluate the Safety and Tolerability of KH658 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration". VAN-2401 is Phase I clinical trial to assess the safety and tolerability of KH658 in subjects with neovascular AMD. KH658 is gene therapy designed to deliver a protein which targets and blocks VEGF via an adeno-associated viral vector. The standard of care for patients with neovascular AMD are anti-...
What is the current status of trial NCT06825858?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 2025-04-07. Estimated completion is 2027-03.
What conditions does trial NCT06825858 study?
This clinical trial studies the following conditions: Age-related Macular Degeneration.
What interventions are being tested in trial NCT06825858?
The interventions under investigation include: KH658 (DRUG).
Who is sponsoring clinical trial NCT06825858?
This trial is sponsored by Chengdu Origen Biotechnology Co., which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06825858 being conducted?
This trial has 3 study locations across Arizona, Illinois, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Age-related Macular Degeneration
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Where NCT06825858's enrollment target sits among peer trials
9 73rd of 74 the lowest of 74 other Age-related Macular Degeneration trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Age-related Macular Degeneration trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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