Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING

An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration

NCT05300724 · View on ClinicalTrials.gov ↗

Study Summary

This is a multicenter prospective study in participants with intermediate age-related macular degeneration (iAMD). One primary objective of this study is to assess iAMD disease progression, by the timeline and rates of conversion for high-risk iAMD at baseline to more advanced atrophic AMD stages. The other primary objective of this observational study is to assess the feasibility of measuring the rate of photoreceptor loss as a potential clinical endpoint. The study will consist of an observation period of approximately 3 years (\~144 weeks) for participants.

Interventions

  • OTHER No intervention

Study Locations (20)

California

  • The Retina Partners — Encino
  • Retina Consultants of Orange County — Fullerton
  • Northern California Retina Vitreous Associates — Mountain View
  • Retina Consultants, San Diego — Poway
  • UC Davis Eye Center — Sacramento
  • Retinal Consultants Medical Group — Sacramento
  • Bay Area Retina Associates — Walnut Creek

Florida

  • Advanced Research — Coral Springs
  • Rand Eye Institute — Deerfield Beach
  • National Ophthalmic Research Institute — Fort Myers
  • Florida Eye Associates — Melbourne

Colorado

  • Southwest Retina Consultants — Durango
  • Eye Care Center of Northern Colorado PC — Longmont

Arkansas

  • Retina Partners of Northwest Arkansas, PLLC — Springdale

Georgia

  • Southeast Retina Center — Augusta

Illinois

  • University Retina and Macula Associates, PC — Oak Forest

Indiana

  • Raj K. Maturi, MD PC — Indianapolis

Iowa

  • Wolfe Eye Clinic — West Des Moines

Trial Details

FieldValue
Enrollment Target 400 participants
Start Date 2022-05-27
Est. Completion 2027-06-30

Sponsor

Genentech

206 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05300724

The ClinicalTrials.gov registry entry for NCT05300724 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 400 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Age-Related Macular Degeneration appearing as the primary indexed condition, and to 1 intervention — of which No intervention is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05300724 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05300724 about?

NCT05300724 is a clinical study titled "An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration". This is a multicenter prospective study in participants with intermediate age-related macular degeneration (iAMD). One primary objective of this study is to assess iAMD disease progression, by the timeline and rates of conversion for high-risk iAMD at baseline to more advanced atrophic AMD stages. T...

What is the current status of trial NCT05300724?

This trial is currently active not recruiting. The enrollment target is 400 participants. The study started on 2022-05-27. Estimated completion is 2027-06-30.

What conditions does trial NCT05300724 study?

This clinical trial studies the following conditions: Age-Related Macular Degeneration. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05300724?

The interventions under investigation include: No intervention (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05300724?

This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05300724 being conducted?

This trial has 20 study locations across Arkansas, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial