Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Tobacco Use Disorder: early-phase trial registry
19 of 75 indexed Tobacco Use Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #178 of 28,707 conditions by registered trial count.
75 US clinical trials · 19 currently recruiting · #178 of 28,707 conditions by registered trial count
Tobacco Use Disorder: 75 US clinical trials tracked, 19 recruiting.
Tobacco Use Disorder is the subject of 75 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 34 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute on Drug Abuse (NIDA), running 7 of these trials.
Enrollment posture brief
Registry condition tobacco-use-disorder
OPEN 19 | RECR 25% | LATE 9 | EARLY 34 | RANK #178 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Overweight (25% recruiting · 198 trials)
Tobacco Use Disorder lists 19 open slots (25% of 75 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Tobacco Use Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Tobacco Use Disorder is recruiting below its size-band peers.
19 of 75 indexed trials (25.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Tobacco Use Disorder trials is spread across many organizations.
National Institute on Drug Abuse (NIDA) accounts for 7 of 75 trials (9.3%). 36 distinct sponsors appear on at least one study for this condition label.
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Typical Tobacco Use Disorder enrolment sits around 108 participants.
Median target enrolment is 108 among the 71 trials that report a genuine target (sentinel values excluded). 32 of those (45.1%) plan for fewer than 100 participants.
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Tobacco Use Disorder research is mostly interventional.
73 interventional and 2 observational studies make up this index (97.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
75 total, page 1 of 2
Young Adult Tobacco/Nicotine and Cannabis Co-use
Medical University of South Carolina
NCT06239350
Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes
University of Vermont
NCT06614504
Cannabis-Tobacco Co-Use Treatment Study
Medical University of South Carolina
NCT06883162
Smoking Cessation Behavioral Treatment Study
University of Missouri-Columbia
NCT03948893
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Yale University
NCT06624137
Cannabidiol for Reducing Cigarette Use
University of California, Los Angeles
NCT06218056
Smoking Cessation CM for Veterans With or at Risk for Cancer
VA Office of Research and Development
NCT06432985
E-cigarette Cessation in Adults Who Co-use Cannabis
Medical University of South Carolina
NCT06688539
Beta-Adrenergic Modulation of Drug Cue Reactivity
University of Oklahoma
NCT05587361
Quit-Smoking Study for Native Hawaiians
University of Hawaii
NCT07075575
A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder
Massachusetts General Hospital
NCT06609902
5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
Johns Hopkins University
NCT05452772
Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity
University of California, Los Angeles
NCT06617312
Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD
VA Office of Research and Development
NCT05723588
Oral Cannabidiol for Tobacco Cessation
Johns Hopkins University
NCT05445804
Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula
Washington D.C. Veterans Affairs Medical Center
NCT06405074
Contingency Management for Veteran Smokers Undergoing Major Elective Surgery
University of California, San Francisco
NCT06678672
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
University of Missouri-Columbia
NCT03713424
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2
Yale University
NCT06006143
Varenicline and Combined NRT for Smoking Cessation
M.D. Anderson Cancer Center
NCT02271919
Omega-3 Fatty Acids for Smoking Cessation in Pregnancy
Vanderbilt University Medical Center
NCT04417595
Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer
M.D. Anderson Cancer Center
NCT00542373
Nicotine Replacement Therapy Prescribing and Lung Cancer Screening in Hospitalized Patients
Medical University of South Carolina
NCT07164404
Developing an E-Cigarette Cessation Intervention for Hispanic/Latina(o) Youth in Florida: The BReATHE Study
Florida International University
NCT07192601
Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation
M.D. Anderson Cancer Center
NCT02697227
A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers
M.D. Anderson Cancer Center
NCT05044546
Use of a Smartphone Mobile Application (App) to Enhance Smoking Cessation Treatment
M.D. Anderson Cancer Center
NCT03519451
Tobacco Zero: Interactive Tobacco Education for Teens
Deschutes Research
NCT00670995
Effectiveness of a Web-Assisted Quitline for Smokeless Tobacco Users
Oregon Research Institute
NCT00820495
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
US Department of Veterans Affairs
NCT00118534
Financial Incentives for Smoking Cessation
University of Pennsylvania
NCT00128375
Smokers' Health Project: Self-Determination and Maintaining Tobacco Abstinence
University of Rochester
NCT00178685
Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
Brown University
NCT02232737
Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
University of Vermont
NCT02250664
Pharmacogenetics, Emotional Reactivity and Smoking
M.D. Anderson Cancer Center
NCT00507728
Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine
University of Minnesota
NCT00710034
Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer
University of Minnesota
NCT01673711
Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
University of Vermont
NCT04092101
Selegiline Patch for Treatment of Nicotine Dependence
Stanford University
NCT01330030
Innovative Interventions for Smoking Cessation
University of Minnesota
NCT01050569
Cognitive Training for Nicotine Dependence
University of Pennsylvania
NCT01252966
Naltrexone Augmentation of Nicotine Patch Therapy - 1
National Institute on Drug Abuse (NIDA)
NCT00218153
Effectiveness of Bupropion for Treating Nicotine Dependence in Young People
National Institute on Drug Abuse (NIDA)
NCT00129272
A Facebook Intervention for Young Sexual and Gender Minority Smokers
University of California, San Francisco
NCT03259360
Intensive Intervention for Smokers - 6
University of California, San Francisco
NCT00217984
Innovative Digital Therapeutic for Smoking Cessation
My Digital Study
NCT03694327
Reduction of Smoking in Cardiac Disease Patients
National Institute on Drug Abuse (NIDA)
NCT00469885
Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers
Ohio State University Comprehensive Cancer Center
NCT02439255
Treatment of Smoking Among Individuals With PTSD
University of Pennsylvania
NCT00937235
Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use
National Institute on Drug Abuse (NIDA)
NCT00218270
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 26 |
| Phase 3 | 3 |
| Phase 4 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Tobacco Use Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Tobacco Use Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Tobacco Use Disorder page
75 registered trials, 19 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 19 Tobacco Use Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute on Drug Abuse (NIDA) sponsors the most Tobacco Use Disorder trials on record, review their full trial history before evaluating a specific study. See National Institute on Drug Abuse (NIDA)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Tobacco Use Disorder condition card totals 75 registered trials; most-linked intervention Varenicline; top US site state Minnesota. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.