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NCT06349577 · ClinicalTrials.gov registry record · NA
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
A NA study of Surgery and Acute Kidney Injury, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- NA
- Development phase
- 1,100
- Enrollment target
- 1
- Study location
NCT06349577: Recruiting NA study of Surgery and Acute Kidney Injury, sponsored by University of Colorado, Denver.
NCT06349577 is a NA study of Surgery and Acute Kidney Injury that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 1,100 participants, below the 52,843-participant average among 120 other Surgery trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06349577, a NA study of Surgery and Acute Kidney Injury, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- NA
- Development phase
- 1,100 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass.
Primary Outcome
Stage 1 (mild), 2 (moderate), or 3 (severe) acute kidney injury according to the Kidney Disease Improving Global Outcomes creatinine criteria (stage 1 = 1.5 to 1.9 times baseline or greater than or equal to 0.3 milligrams per deciliter increase in serum creatinine, stage 2 = 2.0 to 2.9 times baseline in serum creatinine, stage 3 = 3.0 times baseline or increase in serum creatinine greater than or equal to 4.0 milligrams per deciliter or initiation of renal replacement therapy
Conditions Studied
Interventions
- OTHER Non-pulsatile blood flow
- OTHER Pulsatile blood flow
Study Locations (1)
Colorado
- University of Colorado Hospital - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,100 participants |
| Start Date | 2025-05-19 |
| Est. Completion | 2028-10 |
| Phase | NA |
What NCT06349577 shows while recruiting
NCT06349577 is an interventional study that assigns participants to a tested intervention. Its 1,100 participants enrollment target places it among the larger protocols in the corpus, below the 52,843-participant average among 120 other Surgery trials with a reported enrollment target (98% lower).
The record links to 4 conditions, with Surgery appearing as the primary indexed condition, and to 2 interventions - of which Non-pulsatile blood flow is the first listed.
NCT06349577 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT06349577 about?
NCT06349577 is a clinical study titled "Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury". The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during ca...
What is the current status of trial NCT06349577?
This trial is currently recruiting. It is a NA study. The enrollment target is 1,100 participants. The study started on 2025-05-19. Estimated completion is 2028-10.
What conditions does trial NCT06349577 study?
This clinical trial studies the following conditions: Surgery, Acute Kidney Injury, Thrombocytopenia, Hemolysis.
What interventions are being tested in trial NCT06349577?
The interventions under investigation include: Non-pulsatile blood flow (OTHER), Pulsatile blood flow (OTHER).
Who is sponsoring clinical trial NCT06349577?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06349577 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Surgery
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06349577's enrollment target sits among peer trials
1,100 11th of 120 higher than 110 of 120 other Surgery trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Surgery trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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