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NCT06954129 · ClinicalTrials.gov registry record · Phase 4
A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients
A Phase 4 study of Acute Kidney Injury, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 750
- Enrollment target
- 1
- Study location
NCT06954129 is a Phase 4 study of Acute Kidney Injury that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 750 participants, below the 2,321-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (68% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06954129, a Phase 4 study of Acute Kidney Injury, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 750 participants
- Enrollment target
- 1
- Study location
Study Summary
Hospitalized patients with suspected or confirmed infection are commonly treated with vancomycin (VN) in combination with either piperacillin-tazobactam (PT) or cefepime (CP). Although these regimens have similar effectiveness, recent observational evidence suggests they may differ in terms of the risk for acute kidney injury (AKI). Interpretation of existing evidence is complicated by the limitations of creatinine, the standard biomarker used to monitor kidney function, which has poor sensitivity and specificity for drug induced AKI. To address this important knowledge gap, the investigators propose to conduct a pragmatic, open-label, non-inferiority trial that will examine the comparative risk of AKI between these standard-of-care antibiotic combinations using sensitive and specific markers of drug-induced AKI. We hypothesize that the regimen of VN in combination with PT (VN+PT) is noninferior to the regimen of VN in combination with CP (VN+CP) in terms of AKI risk.
Conditions Studied
Interventions
- DRUG Vancomycin
- DRUG Piperacillin-tazobactam
- DRUG Cefepime
Study Locations (1)
Pennsylvania
- University of Pennsylvania Health System - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 750 participants |
| Start Date | 2026-01-28 |
| Est. Completion | 2029-07 |
| Phase | Phase 4 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06954129
The ClinicalTrials.gov registry entry for NCT06954129 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 750 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,321-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (68% lower). The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Acute Kidney Injury appearing as the primary indexed condition, and to 3 interventions - of which Vancomycin is the first listed.
NCT06954129 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06954129 about?
NCT06954129 is a clinical study titled "A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients". Hospitalized patients with suspected or confirmed infection are commonly treated with vancomycin (VN) in combination with either piperacillin-tazobactam (PT) or cefepime (CP). Although these regimens have similar effectiveness, recent observational evidence suggests they may differ in terms of the r...
What is the current status of trial NCT06954129?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 750 participants. The study started on 2026-01-28. Estimated completion is 2029-07.
What conditions does trial NCT06954129 study?
This clinical trial studies the following conditions: Acute Kidney Injury.
What interventions are being tested in trial NCT06954129?
The interventions under investigation include: Vancomycin (DRUG), Piperacillin-tazobactam (DRUG), Cefepime (DRUG).
Who is sponsoring clinical trial NCT06954129?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06954129 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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