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NCT07472426 · ClinicalTrials.gov registry record · NA
Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat
A NA study of Acute Kidney Injury and Exertional Heat Illness, sponsored by University of Northern Iowa.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT07472426: Recruiting NA study of Acute Kidney Injury and Exertional Heat Illness, sponsored by University of Northern Iowa.
NCT07472426 is a NA study of Acute Kidney Injury and Exertional Heat Illness that is actively recruiting participants, run by University of Northern Iowa. The registered enrollment target is 20 participants, below the 2,331-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07472426, a NA study of Acute Kidney Injury and Exertional Heat Illness, is actively recruiting participants, sponsored by University of Northern Iowa.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk, and cognitive performance in active, young, healthy volunteers. The main questions it aims to answer are: 1. Does one-week of creatine supplementation alter urinary markers of inflammation (cytokines) during exercise in the heat when compared to placebo? 2. Does one-week of creatine supplementation alter markers of AKI during exercise in the heat when compared to placebo? 3. Does one-week of creatine supplementation attenuate reductions in cognitive measures as a response of fatigue from exertional heat stress. Researchers will compare creatine monohydrate to a placebo (maltodextrin) to see if it alters inflammation, risk of acute kidney injury, and cognition after exercise in the heat. Participants will : * Complete a baseline aerobic exercise test to measure VO2max * Ingest 20 grams per day of creatine monohydrate or placebo (maltodextrin) for seven consecutive days * Cycle for 90 minutes in a heated chamber (38 C, \~40% relative humidity), alternating low- and high-intensity exercise * Self-collect urine before, after, and one-hour after exercise * Self-insert a rectal thermistor to measure core temperature * Complete cognitive tasks using the NIH toolbox before and after exercise to assess cognition * Complete the other condition (placebo or creatine) at least 21 days later
Primary Outcome
Concentrations of both IGBFP7 and TIMP-2 will be measured in the urine. The mathematical product of these values (IGFBP7 x TIMP-2) will then be calculated and reported for each time point.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Creatine Monohydrate
- DIETARY_SUPPLEMENT Maltodextrin (Placebo)
Study Locations (1)
Iowa
- Wellness and Recreation Center - Cedar Falls
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-03-12 |
| Est. Completion | 2027-05 |
| Phase | NA |
What NCT07472426 shows while recruiting
NCT07472426 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 2,331-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Acute Kidney Injury appearing as the primary indexed condition, and to 2 interventions - of which Creatine Monohydrate is the first listed.
NCT07472426 reports a single indexed study location in Iowa.
Frequently Asked Questions
What is clinical trial NCT07472426 about?
NCT07472426 is a clinical study titled "Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat". The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk, and cognitive performance in active, young, healthy volunteers. The main questions it aims to answer are: 1. Does one-week of creatine supp...
What is the current status of trial NCT07472426?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2026-03-12. Estimated completion is 2027-05.
What conditions does trial NCT07472426 study?
This clinical trial studies the following conditions: Acute Kidney Injury, Exertional Heat Illness.
What interventions are being tested in trial NCT07472426?
The interventions under investigation include: Creatine Monohydrate (DIETARY_SUPPLEMENT), Maltodextrin (Placebo) (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT07472426?
This trial is sponsored by University of Northern Iowa, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07472426 being conducted?
This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07472426's enrollment target sits among peer trials
20 69th of 74 higher than 6 of 74 other Acute Kidney Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Kidney Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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