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NCT07472426 · ClinicalTrials.gov registry record · NA
Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat
A NA study of Acute Kidney Injury and Exertional Heat Illness, sponsored by University of Northern Iowa.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT07472426 is a NA study of Acute Kidney Injury and Exertional Heat Illness that is actively recruiting participants, run by University of Northern Iowa. The registered enrollment target is 20 participants, below the 2,331-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07472426, a NA study of Acute Kidney Injury and Exertional Heat Illness, is actively recruiting participants, sponsored by University of Northern Iowa.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk, and cognitive performance in active, young, healthy volunteers. The main questions it aims to answer are: 1. Does one-week of creatine supplementation alter urinary markers of inflammation (cytokines) during exercise in the heat when compared to placebo? 2. Does one-week of creatine supplementation alter markers of AKI during exercise in the heat when compared to placebo? 3. Does one-week of creatine supplementation attenuate reductions in cognitive measures as a response of fatigue from exertional heat stress. Researchers will compare creatine monohydrate to a placebo (maltodextrin) to see if it alters inflammation, risk of acute kidney injury, and cognition after exercise in the heat. Participants will : * Complete a baseline aerobic exercise test to measure VO2max * Ingest 20 grams per day of creatine monohydrate or placebo (maltodextrin) for seven consecutive days * Cycle for 90 minutes in a heated chamber (38 C, \~40% relative humidity), alternating low- and high-intensity exercise * Self-collect urine before, after, and one-hour after exercise * Self-insert a rectal thermistor to measure core temperature * Complete cognitive tasks using the NIH toolbox before and after exercise to assess cognition * Complete the other condition (placebo or creatine) at least 21 days later
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Creatine Monohydrate
- DIETARY_SUPPLEMENT Maltodextrin (Placebo)
Study Locations (1)
Iowa
- Wellness and Recreation Center - Cedar Falls
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-03-12 |
| Est. Completion | 2027-05 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07472426
The ClinicalTrials.gov registry entry for NCT07472426 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,331-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (99% lower). The listed sponsor is University of Northern Iowa, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Acute Kidney Injury appearing as the primary indexed condition, and to 2 interventions - of which Creatine Monohydrate is the first listed.
NCT07472426 reports 1 study location spanning 1 distinct geographic area - top geographies include Iowa.
Frequently Asked Questions
What is clinical trial NCT07472426 about?
NCT07472426 is a clinical study titled "Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat". The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk, and cognitive performance in active, young, healthy volunteers. The main questions it aims to answer are: 1. Does one-week of creatine supp...
What is the current status of trial NCT07472426?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2026-03-12. Estimated completion is 2027-05.
What conditions does trial NCT07472426 study?
This clinical trial studies the following conditions: Acute Kidney Injury, Exertional Heat Illness.
What interventions are being tested in trial NCT07472426?
The interventions under investigation include: Creatine Monohydrate (DIETARY_SUPPLEMENT), Maltodextrin (Placebo) (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT07472426?
This trial is sponsored by University of Northern Iowa, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07472426 being conducted?
This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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