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RECRUITING Phase 2

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

NCT07215702 · View on ClinicalTrials.gov ↗

Study Summary

This study will enroll adults aged 18 to 80 years diagnosed with sepsis due to a suspected or confirmed bacterial infection, within 7 days of being admitted to the hospital, and who have also developed acute kidney injury within 72 hours of the onset of sepsis. Eligible participants will be randomly assigned to receive either AZD4144 or a placebo intravenously once daily for the number of days specified in the CSP. During this Treatment Period, participants will undergo daily safety monitoring, as well as blood and urine sample collection and other assessments. After the Treatment Period, participants will continue to be monitored for safety and other assessments during each additional day they remain hospitalized (if applicable) as well as during up to 2 follow up visits after discharge. The main goal is to compare specific kidney function measurements between those participants receiving AZD4144 and those receiving the placebo.

Interventions

  • DRUG Placebo
  • DRUG AZD4144

Study Locations (20)

Other

  • Research Site — CABA
  • Research Site — Ciudad de Buenos Aires
  • Research Site — La Plata
  • Research Site — Rosario

New York

  • Research Site — The Bronx
  • Research Site — The Bronx
  • Research Site — The Bronx

North Carolina

  • Research Site — Chapel Hill
  • Research Site — Winston-Salem

Pennsylvania

  • Research Site — Philadelphia
  • Research Site — Pittsburgh

Arizona

  • Research Site — Tucson

California

  • Research Site — Newport Beach

Kansas

  • Research Site — Kansas City

Maryland

  • Research Site — Baltimore

Trial Details

FieldValue
Enrollment Target 124 participants
Start Date 2026-02-10
Est. Completion 2027-02-11
Phase Phase 2

Sponsor

AstraZeneca

1,053 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07215702

The ClinicalTrials.gov registry entry for NCT07215702 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 124 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Sepsis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07215702 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, New York, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07215702 about?

NCT07215702 is a clinical study titled "A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.". This study will enroll adults aged 18 to 80 years diagnosed with sepsis due to a suspected or confirmed bacterial infection, within 7 days of being admitted to the hospital, and who have also developed acute kidney injury within 72 hours of the onset of sepsis. Eligible participants will be randomly...

What is the current status of trial NCT07215702?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 124 participants. The study started on 2026-02-10. Estimated completion is 2027-02-11.

What conditions does trial NCT07215702 study?

This clinical trial studies the following conditions: Sepsis, Acute Kidney Injury. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07215702?

The interventions under investigation include: Placebo (DRUG), AZD4144 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07215702?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07215702 being conducted?

This trial has 20 study locations across Arizona, California, Kansas, Maryland, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial