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NCT05349292 · ClinicalTrials.gov registry record
Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels
A clinical trial of Acute Kidney Injury, sponsored by University of Maryland, Baltimore.
- Recruiting
- Registry status
- 100
- Enrollment target
- 1
- Study location
NCT05349292: Recruiting study of Acute Kidney Injury, sponsored by University of Maryland, Baltimore.
NCT05349292 is a study of Acute Kidney Injury that is actively recruiting participants, run by University of Maryland, Baltimore. The registered enrollment target is 100 participants, below the 2,330-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05349292, a study of Acute Kidney Injury, is actively recruiting participants, sponsored by University of Maryland, Baltimore.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
Acute normovolemic hemodilution (ANH) is performed as a blood conservation technique during surgical procedures with high risk for significant blood loss. It is done by taking out some of the patients blood before surgery actually begins and storing this blood inside of the operating room and giving it back to the patient at the end of surgery when most of the expected surgical bleeding has already occurred. This practice reduces the amount of bleeding that occurs after surgery and also reduces the amount of blood transfusions given to the patient after surgery. Transfusion of blood products from the blood bank may cause problems such as transfusion reactions and infections like hepatitis, and also increases cost. 3 meta-analyses and several smaller trials have shown improvement in blood transfusion rates with the use of ANH, however there is no evidence of improvement in other complication rates, morbidity and mortality, length of stay or cost. In most types of surgery, when ANH is done, large volumes of IV fluids are given to the patient to prevent a drop in circulatory volume and blood pressure. However during heart surgery, this can cause significant levels of hemodilution in addition to that caused by use of the heart-lung machine. In order to minimize hemodilution when ANH is performed during heart surgery, a smaller amount of IV fluids are given to the patient after blood is drawn. Vasoactive medications are then administered to prevent the blood pressure from dropping. Kidney injury is a recognized complication that may occur after heart surgery. It may be caused by low blood volume, low blood pressure and anemia. It is not known whether performance of ANH and use of the heart-lung machine may increase risk for kidney injury. Kidney injury is associated with increased risk for other medical complications and death. This increased risk for kidney injury arising from ANH has not been evaluated. This study will therefore compare patients treated with ANH to
Primary Outcome
Urinary levels of NGAL and KIM-1 biomarkers during the first 24 hours after CABG surgery
Conditions Studied
Interventions
- OTHER ANH
Study Locations (1)
Maryland
- University of Maryland Medical Center - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2024-01-31 |
| Est. Completion | 2027-06 |
What NCT05349292 shows while recruiting
NCT05349292 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 2,330-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Acute Kidney Injury appearing as the primary indexed condition, and to 1 intervention - of which ANH is the first listed.
NCT05349292 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT05349292 about?
NCT05349292 is a clinical study titled "Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels". Acute normovolemic hemodilution (ANH) is performed as a blood conservation technique during surgical procedures with high risk for significant blood loss. It is done by taking out some of the patients blood before surgery actually begins and storing this blood inside of the operating room and giving...
What is the current status of trial NCT05349292?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2024-01-31. Estimated completion is 2027-06.
What conditions does trial NCT05349292 study?
This clinical trial studies the following conditions: Acute Kidney Injury.
What interventions are being tested in trial NCT05349292?
The interventions under investigation include: ANH (OTHER).
Who is sponsoring clinical trial NCT05349292?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05349292 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05349292's enrollment target sits among peer trials
100 44th of 74 higher than 28 of 74 other Acute Kidney Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Kidney Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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