Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06150742 · ClinicalTrials.gov registry record · NA
Nafamostat Efficacy in Phase 3 Registrational CRRT Study
A NA study of Acute Kidney Injury, sponsored by Talphera.
- Recruiting
- Registry status
- NA
- Development phase
- 70
- Enrollment target
- 10
- Study locations
NCT06150742: Recruiting NA study of Acute Kidney Injury, sponsored by Talphera.
NCT06150742 is a NA study of Acute Kidney Injury that is actively recruiting participants, run by Talphera. The registered enrollment target is 70 participants, below the 2,330-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (97% lower). The trial reports 10 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06150742, a NA study of Acute Kidney Injury, is actively recruiting participants, sponsored by Talphera.
- RECRUITING
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
- 10
- Study locations
Study Summary
A prospective, randomized, placebo-controlled clinical study to investigate the safety and efficacy of Niyad (nafamostat mesylate) for anticoagulation of extracorporeal blood circulating through a dialysis filter in patients undergoing CRRT who cannot tolerate heparin or are at higher risk for bleeding.
Primary Outcome
mean post-filter activated clotting time (ACT)
Conditions Studied
Interventions
- DEVICE Niyad (nafamostat mesylate)
- DEVICE Placebo (0.9% NaCl)
Study Locations (10)
New York
- Northwell Health - Great Neck
- Mount Sinai - New York
California
- University of California Los Angeles - Los Angeles
Florida
- AdventHealth - Orlando
Michigan
- Henry Ford Health - Detroit
New Mexico
- University of New Mexico - Albuquerque
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
Pennsylvania
- University of Pittsburgh Medical Center - Pittsburgh
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2024-08-15 |
| Est. Completion | 2025-12 |
| Phase | NA |
What NCT06150742 shows while recruiting
NCT06150742 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 2,330-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Acute Kidney Injury appearing as the primary indexed condition, and to 2 interventions - of which Niyad (nafamostat mesylate) is the first listed.
NCT06150742 lists 10 locations in 9 states (New York, California, Florida).
Frequently Asked Questions
What is clinical trial NCT06150742 about?
NCT06150742 is a clinical study titled "Nafamostat Efficacy in Phase 3 Registrational CRRT Study". A prospective, randomized, placebo-controlled clinical study to investigate the safety and efficacy of Niyad (nafamostat mesylate) for anticoagulation of extracorporeal blood circulating through a dialysis filter in patients undergoing CRRT who cannot tolerate heparin or are at higher risk for bleed...
What is the current status of trial NCT06150742?
This trial is currently recruiting. It is a NA study. The enrollment target is 70 participants. The study started on 2024-08-15. Estimated completion is 2025-12.
What conditions does trial NCT06150742 study?
This clinical trial studies the following conditions: Acute Kidney Injury.
What interventions are being tested in trial NCT06150742?
The interventions under investigation include: Niyad (nafamostat mesylate) (DEVICE), Placebo (0.9% NaCl) (DEVICE).
Who is sponsoring clinical trial NCT06150742?
This trial is sponsored by Talphera, which has 18 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06150742 being conducted?
This trial has 10 study locations across California, Florida, Michigan, New Mexico, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Acute Kidney Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06150742's enrollment target sits among peer trials
70 49th of 74 higher than 25 of 74 other Acute Kidney Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Kidney Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes
RECRUITING · NA
-
Initial Resuscitation for Acute Kidney Injury in Cirrhosis
RECRUITING · NA
-
CTSN Embolic Protection Trial
RECRUITING · NA
-
A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention
RECRUITING · NA
-
Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury
RECRUITING · NA
-
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00969111 · 70 participants · NA
Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomy
- NCT01712620 · 70 participants · Phase 2
Spironolactone for Pulmonary Arterial Hypertension
- NCT02143830 · 70 participants · Phase 2
HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy
- NCT02601339 · 70 participants
NIRS Monitoring in Premature Infants
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI