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NCT06937307 · ClinicalTrials.gov registry record · Phase 2
Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury
A Phase 2 study of Acute Kidney Injury and Cirrhosis, sponsored by Giuseppe Cullaro, MD.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 75
- Enrollment target
- 1
- Study location
NCT06937307: Recruiting Phase 2 study of Acute Kidney Injury and Cirrhosis, sponsored by Giuseppe Cullaro, MD.
NCT06937307 is a Phase 2 study of Acute Kidney Injury and Cirrhosis that is actively recruiting participants, run by Giuseppe Cullaro, MD. The registered enrollment target is 75 participants, below the 2,330-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06937307, a Phase 2 study of Acute Kidney Injury and Cirrhosis, is actively recruiting participants, sponsored by Giuseppe Cullaro, MD.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
This study tests whether a medication called droxidopa can help improve blood flow to the kidneys in people with liver cirrhosis who develop kidney problems while in the hospital. When someone with cirrhosis experiences kidney injury, having better blood pressure can help their kidneys recover. Droxidopa is an oral medication that may help raise blood pressure without requiring intensive care or invasive treatments. The study will compare droxidopa to a placebo (inactive pill) in 75 people hospitalized with cirrhosis and kidney injury. Participants will take either droxidopa or placebo pills for 28 days and be monitored for an additional 30 days. Researchers will measure changes in blood pressure and kidney function to determine if droxidopa is effective and safe for these patients. This research could identify a new treatment option for a serious complication of liver disease.
Primary Outcome
The difference in mean arterial pressure between treatment groups over the 28-day treatment period, assessed using a linear mixed-effects model with fixed effects for treatment group and time, plus their interaction, while accounting for between-subject variability through random intercepts.
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Droxidopa capsules
Study Locations (1)
New York
- Columbia University Irving Medical Center - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2025-05-27 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 2 |
What NCT06937307 shows while recruiting
NCT06937307 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 2,330-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (97% lower).
The record links to 3 conditions, with Acute Kidney Injury appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06937307 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT06937307 about?
NCT06937307 is a clinical study titled "Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury". This study tests whether a medication called droxidopa can help improve blood flow to the kidneys in people with liver cirrhosis who develop kidney problems while in the hospital. When someone with cirrhosis experiences kidney injury, having better blood pressure can help their kidneys recover. Drox...
What is the current status of trial NCT06937307?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 75 participants. The study started on 2025-05-27. Estimated completion is 2027-12-31.
What conditions does trial NCT06937307 study?
This clinical trial studies the following conditions: Acute Kidney Injury, Cirrhosis, Decompensated Cirrhosis of Liver.
What interventions are being tested in trial NCT06937307?
The interventions under investigation include: Placebo (OTHER), Droxidopa capsules (DRUG).
Who is sponsoring clinical trial NCT06937307?
This trial is sponsored by Giuseppe Cullaro, MD, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06937307 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Acute Kidney Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06937307's enrollment target sits among peer trials
75 48th of 74 higher than 27 of 74 other Acute Kidney Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Kidney Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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