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NCT03994120 · ClinicalTrials.gov registry record · NA
Modulating the Hippocampal and Striatal Memory Networks With rTMS
A NA study, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- NA
- Development phase
- 13
- Enrollment target
NCT03994120: Completed NA study, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT03994120 is a NA study that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 13 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03994120, a NA study, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- NA
- Development phase
- 13 participants
- Enrollment target
Study Summary
Background: People have 2 memory systems. One helps them learn skills and the other helps them learn facts. Repetitive transcranial magnetic stimulation (rTMS) uses electric currents to activate brain cells. This can make small changes in how brain systems operate. Researchers will use rTMS to change how memory systems work and to see if changing one system causes the other to change too. This could help find ways to improve learning and memory in people with memory disorders. Objective: To learn how different memory systems work with each other. Eligibility: Healthy adults ages 18-40 who are not pregnant Design: Potential participants will be screened with a neurological exam if they have not had one from NINDS in the past 2 years. They may have urine tests. Eligible participants will have 5-10 visits at NIH. Each visit will last 1-6 hours. Visits 1-4 will each take place 1 day apart. At visit 1, participants will have an MRI and take memory tests. For MRI, they will lie on a table that slides in and out of a cylinder that takes pictures of their brain. They will also have rTMS. For rTMS, a metal coil is held on their scalp. Brief electrical currents pass through the coil. At visits 2 and 3, participants will have rTMS. At visit 4, participants will have an MRI and do memory tests. About a week later, participants will have visit 5. They will have an MRI and do memory tests. Participants may be asked to have more visits if any technical problems occur. Participant involvement will last 2 weeks. ...
Primary Outcome
Participants underwent repetitive transcranial magnetic stimulation (rTMS) to the caudate network, which supports learning skills. rTMS uses electric currents to activate brain cells, which can temporarily change brain connections and memory. We measured how rTMS affects caudate network brain connectivity. These changes were observed with MRI. To measure brain connection strength, we calculated how closely neural activity correlates in the caudate network. We measured how rTMS affects connection
Interventions
- OTHER RTMS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2019-09-26 |
| Est. Completion | 2021-03-24 |
| Phase | NA |
What the finished NCT03994120 record still lists
NCT03994120 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which RTMS is the first listed.
NCT03994120 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03994120 about?
NCT03994120 is a clinical study titled "Modulating the Hippocampal and Striatal Memory Networks With rTMS". Background: People have 2 memory systems. One helps them learn skills and the other helps them learn facts. Repetitive transcranial magnetic stimulation (rTMS) uses electric currents to activate brain cells. This can make small changes in how brain systems operate. Researchers will use rTMS to chan...
What is the current status of trial NCT03994120?
This trial is currently completed. It is a NA study. The enrollment target is 13 participants. The study started on 2019-09-26. Estimated completion is 2021-03-24.
What interventions are being tested in trial NCT03994120?
The interventions under investigation include: RTMS (OTHER).
Who is sponsoring clinical trial NCT03994120?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03994120's enrollment target sits among peer trials
13 1911th of 2000 higher than 88 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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