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NCT03018262 · ClinicalTrials.gov registry record
Neurophysiology of Surround Inhibition in the Human Motor Cortex
A clinical trial, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- 53
- Enrollment target
NCT03018262: Completed study, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT03018262 is a clinical trial that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 53 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03018262 has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- 53 participants
- Enrollment target
Study Summary
Background: Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement. They want to learn about which brain regions could be abnormal in people with movement disorders. Objective: To better understand how the brain controls movement. Eligibility: Healthy, right-handed adults age 18-70 years old. Design: Participants will be screened with a physical exam and questions about their handedness. They may have a urine test. Participants will have 1 or 2 clinic visits. The first visit will last about 1.5 hours. The second will last about 3 hours. Participants will have structural magnetic resonance imaging (MRI). A strong magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal cylinder. Participants may have transcranial magnetic stimulation. A wire coil is held on the scalp. A brief electrical current is passed through the coil and creates a magnetic pulse that stimulates the brain. Participants will wear a pair of glasses or a headband with small sensors so researchers can track head position. Participants will perform a simple index finger movement task. Participants may have surface electromyography from at least two hand muscles. Small metal disk or adhesive pad electrodes will be taped to the skin. Participants will be seated in a comfortable chair with their hands placed on a pillow. Participants may have an electroencephalography. A cap with small disc electrodes will be placed on the scalp.
Primary Outcome
TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.
Interventions
- DEVICE TMS - sub-study 1
- DEVICE TMS - sub-study 2
- DEVICE TMS - sub-study 3
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 53 participants |
| Start Date | 2017-02-07 |
| Est. Completion | 2021-03-24 |
What the finished NCT03018262 record still lists
NCT03018262 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 53 participants, a relatively small participant target.
The record links to 0 conditions, and to 3 interventions - of which TMS - sub-study 1 is the first listed.
NCT03018262 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03018262 about?
NCT03018262 is a clinical study titled "Neurophysiology of Surround Inhibition in the Human Motor Cortex". Background: Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement. They want to learn about which brain regions could be abnormal in people with movement disorders. Objective: To better understa...
What is the current status of trial NCT03018262?
This trial is currently completed. The enrollment target is 53 participants. The study started on 2017-02-07. Estimated completion is 2021-03-24.
What interventions are being tested in trial NCT03018262?
The interventions under investigation include: TMS - sub-study 1 (DEVICE), TMS - sub-study 2 (DEVICE), TMS - sub-study 3 (DEVICE).
Who is sponsoring clinical trial NCT03018262?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
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