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NCT07613112 · ClinicalTrials.gov registry record
Longitudinal Natural History Protocol for PRKN- and PINK1-Linked PD
A clinical trial, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Not yet
- Registry status
- 70
- Enrollment target
NCT07613112: Clinical Trial study, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT07613112 is a clinical trial that has not yet begun recruiting, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 70 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07613112 has not yet begun recruiting, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- NOT YET RECRUITING
- Registry status
- 70 participants
- Enrollment target
Study Summary
Background: Parkinson s disease is a neurologic disorder that affects movement. Its cause is unknown, and it usually begins later in life. Gene changes (PRKN and PINK1) can also cause rare types of Parkinson s disease that start at a young age. Researchers want to conduct a natural history study to learn more about how genes play a role in Parkinson s disease. Objective: To collect data and biological samples from people with different types of Parkinson s disease. Eligibility: People aged 18 to 80 years with either Parkinson s disease or PRKN- and PINK1-linked Parkinson s disease. Healthy volunteers are also needed. Design: Participants will have 6 clinic visits over 5 years. Each visit may take 1 to 3 days. During each visit: Participants will have a physical exam. The exam will be videotaped. They will answer questions about their movement, thinking, mood, and sense of smell. The extent of any symptoms of Parkinson s disease will be evaluated: Participants movements may be assessed with a finger tapping test. They may be asked to scratch and sniff different scented strips to identify odors. They will wear motion sensors on their arms, legs, chest, and back at the clinic. They will wear motion sensor devices on their wrists at home for 1 week. Blood and urine samples will be collected. Other tests are optional: Magnetic resonance imaging (MRI) scan of the brain. Participants will lie on a table that slides into a tube. Lumbar puncture (spinal tap). A thin needle will be inserted into their lower back to draw out a sample of the fluid around their spinal cord. Muscle biopsy. A small sample of tissue will be taken from the leg.
Primary Outcome
Measured by annual change in MDS Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2026-10-01 |
| Est. Completion | 2036-05-30 |
What is known before NCT07613112 opens enrollment
NCT07613112 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 70 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT07613112 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07613112 about?
NCT07613112 is a clinical study titled "Longitudinal Natural History Protocol for PRKN- and PINK1-Linked PD". Background: Parkinson s disease is a neurologic disorder that affects movement. Its cause is unknown, and it usually begins later in life. Gene changes (PRKN and PINK1) can also cause rare types of Parkinson s disease that start at a young age. Researchers want to conduct a natural history study to...
What is the current status of trial NCT07613112?
This trial is currently not yet recruiting. The enrollment target is 70 participants. The study started on 2026-10-01. Estimated completion is 2036-05-30.
Who is sponsoring clinical trial NCT07613112?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
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