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NCT02689466 · ClinicalTrials.gov registry record
Cholinergic Receptor Imaging in Dystonia
A clinical trial of Dystonia and Cervical Dystonia, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- 31
- Enrollment target
- 1
- Study location
NCT02689466: Completed study of Dystonia and Cervical Dystonia, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT02689466 is a study of Dystonia and Cervical Dystonia that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 31 participants, below the 539-participant average among 28 other Dystonia trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02689466, a study of Dystonia and Cervical Dystonia, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- 31 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Dystonia is a movement disorder in which a person s muscles contract on their own. This causes different parts of the body to twist or turn. The cause of this movement is unknown. Researchers think it may have to do with a chemical called acetylcholine. They want to learn more about why acetylcholine in the brain doesn t work properly in people with dystonia. Objective: To better understand how certain parts of the brain take up acetylcholine in people with dystonia. Eligibility: Adults at least 18 years old who have DYT1 dystonia or cervical dystonia. Healthy adult volunteers. Design: Participants will be screened with a medical history, physical exam, and pregnancy test. Study visit 1: Participants will have a magnetic resonance imaging (MRI) scan of the brain. The MRI scanner is a metal cylinder in a strong magnetic field that takes pictures of the brain. Participants will lie on a table that slides in and out of the cylinder. Study visit 2: Participants will have a positron emission tomography (PET) scan. The PET scanner is shaped like a doughnut. Participants will lie on a bed that slides in and out of the scanner. A small amount of a radioactive chemical that can be detected by the PET scanner will be given through an IV line to measure how the brain takes up acetylcholine. ...
Primary Outcome
Characterization of the M2 muscarinic acetylcholine receptor binding in cervical dystonia patients as measured with high-resolution PET using \[18F\]FP-TZTP.
Conditions Studied
Interventions
- DRUG [18F]FP-TZTP
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2016-12-16 |
| Est. Completion | 2021-11-26 |
What the finished NCT02689466 record still lists
NCT02689466 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 539-participant average among 28 other Dystonia trials with a reported enrollment target (94% lower).
The record links to 4 conditions, with Dystonia appearing as the primary indexed condition, and to 1 intervention - of which [18F]FP-TZTP is the first listed.
NCT02689466 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT02689466 about?
NCT02689466 is a clinical study titled "Cholinergic Receptor Imaging in Dystonia". Background: Dystonia is a movement disorder in which a person s muscles contract on their own. This causes different parts of the body to twist or turn. The cause of this movement is unknown. Researchers think it may have to do with a chemical called acetylcholine. They want to learn more about why...
What is the current status of trial NCT02689466?
This trial is currently completed. The enrollment target is 31 participants. The study started on 2016-12-16. Estimated completion is 2021-11-26.
What conditions does trial NCT02689466 study?
This clinical trial studies the following conditions: Dystonia, Cervical Dystonia, Focal Dystonia, Movement Disorder.
What interventions are being tested in trial NCT02689466?
The interventions under investigation include: [18F]FP-TZTP (DRUG).
Who is sponsoring clinical trial NCT02689466?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02689466 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT02689466's enrollment target sits among peer trials
31 22nd of 28 higher than 7 of 28 other Dystonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Dystonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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