National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

490 total trials 50 currently recruiting 398 completed

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors 490 registered US clinical trials on ClinicalTrials.gov, 50 of them currently recruiting, and 398 completed. 69 of these trials are in Phase 3-4 (later-stage) and 178 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 25 trials.

Trial Pipeline

490 total, page 1 of 10

RECRUITING

Hepatic Lipid Metabolism-Alcohol Use Disorder

NCT07191561

RECRUITING Phase 1

Ketoconazole Effects on the Daily Cortisol Rhythm in Mild Autonomous Cortisol Secretion

NCT07649317

RECRUITING Phase 2

Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus

NCT07142252

RECRUITING Phase 2

Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors

NCT07444723

RECRUITING

Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study

NCT06730113

RECRUITING Phase 2

VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B

NCT06092333

RECRUITING Phase 2

Desmopressin Stimulation Test Performance in ACTH-Dependent Cushing Syndrome

NCT06635629

RECRUITING NA

Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation

NCT06169137

RECRUITING NA

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

NCT06325722

RECRUITING NA

Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose

NCT06223555

RECRUITING NA

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

NCT06044935

RECRUITING

Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)

NCT05996536

RECRUITING Phase 2

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

NCT05832229

RECRUITING NA

The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

NCT05545306

RECRUITING

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

NCT04685200

RECRUITING Phase 2

Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance

NCT05470504

RECRUITING

A Natural History Study of Metabolic Sizing in Health and Disease

NCT05398783

RECRUITING

Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With Lipodystrophy

NCT05419037

RECRUITING

Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment

NCT05213598

RECRUITING

Early Tracking of Childhood Health Determinants (ETCHED) Study

NCT03481829

RECRUITING Phase 1

Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake

NCT04799301

RECRUITING Phase 2

TReatment for ImmUne Mediated PathopHysiology

NCT04862221

RECRUITING

Evaluation of Patients With Gastrointestinal Disease

NCT05041374

RECRUITING

Natural History Study of Parathyroid Disorders

NCT04969926

RECRUITING Phase 2

The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer

NCT04927416

RECRUITING Phase 2

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

NCT03841617

RECRUITING Phase 2

Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

NCT03884075

RECRUITING

Study of Endocrine-Related Conditions and Physiology

NCT03867448

RECRUITING

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

NCT03374215

RECRUITING Phase 1

The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists

NCT03049462

RECRUITING

Evaluation of Adults With Endocrine and Metabolic-Related Conditions

NCT02830308

RECRUITING

Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism

NCT02692885

RECRUITING

Natural History of Noncirrhotic Portal Hypertension

NCT02417740

RECRUITING Phase 2

Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome

NCT02019706

RECRUITING NA

New Heart Imaging Techniques to Evaluate Possible Heart Disease

NCT01399385

RECRUITING Phase 2

Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

NCT00977977

RECRUITING

Clinical and Genetic Studies in Familial Non-medullary Thyroid Cancer

NCT01109420

RECRUITING Phase 2

Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment

NCT00739362

RECRUITING

Natural History of Familial Carcinoid Tumor

NCT00646022

RECRUITING

Blood Sampling for Research Related to Sickle Cell Disease

NCT00542230

RECRUITING

Physical and Behavioral Traits of Overweight and Obese Adults

NCT00428987

RECRUITING

Urinary Vitamin C Loss in Diabetic Subjects

NCT00071526

RECRUITING

Family Investigation of Nephropathy and Diabetes (F.I.N.D.)

NCT00342927

RECRUITING

Diabetes and Heart Disease Risk in Blacks

NCT00001853

RECRUITING

Immune System Related Kidney Disease

NCT00001979

RECRUITING

Evaluation of Patients With Liver Disease

NCT00001971

RECRUITING

Diagnosing and Treating Low Blood Sugar Levels

NCT00001276

RECRUITING

Studies on Tumors of the Thyroid

NCT00001160

RECRUITING

Natural History of Thyroid Function Disorders

NCT00001159

RECRUITING

Genetic Studies of Insulin and Diabetes

NCT00001987

Page 1 of 10 Next →

Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 136
Phase 3 55
Phase 4 14

What the Pipeline for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Shows

According to the ClinicalTrials.gov registry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is linked to 490 US clinical trials across every stage of research activity. Of those, 50 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 398 are already marked complete, representing roughly 81% of the total.

The phase mix for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) reports 69 late-stage studies (Phase 3 and Phase 4 combined) and 178 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is Obesity with 25 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.