Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Lipodystrophy clinical trials
Every US clinical trial registered for Lipodystrophy — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
12 US clinical trials · 2 currently recruiting
The research picture
Lipodystrophy has 12 registered US clinical trials, 2 of them open to new participants right now — about 17% of the total.
- 2
- recruiting participants now
- 17%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 6
- top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With Lipodystrophy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05419037
Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05996536
Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02262806
Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02262832
A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00069004
Changing to Nonprotease Inhibitor Treatment to Improve Side Effects
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00021463
Lipodystrophy Connect Patient Registry
PatientCrossroads
NCT02577952
Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV Patients
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00028314
Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00119379
Exercise and Pioglitazone for HIV-Metabolic Syndromes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00639457
Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy Volunteers
Topokine Therapeutics
NCT02647853
Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02639286
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Lipodystrophy Trial Landscape
ClinicalTrials.gov lists 12 US studies indexed under Lipodystrophy, and 2 of those are currently open to recruitment — roughly 17% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Lipodystrophy shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Lipodystrophy is led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) with 6 indexed trials, alongside 3 other organizations in the top contributor list. The list on this page surfaces up to 12 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Lipodystrophy?
PlainTrial tracks 12 US clinical trials for Lipodystrophy, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Lipodystrophy?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.