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ClinicalTrials.gov 2 recruiting now official registry

Lipodystrophy clinical trials

Every US clinical trial registered for Lipodystrophy — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

12 US clinical trials · 2 currently recruiting

The research picture

Lipodystrophy has 12 registered US clinical trials, 2 of them open to new participants right now — about 17% of the total.

2
recruiting participants now
17%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
6
top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 90 participants

Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05419037

RECRUITING 14 participants

Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05996536

ACTIVE NOT RECRUITING Phase 2 29 participants

Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02262806

ACTIVE NOT RECRUITING Phase 3 24 participants

Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02262832

COMPLETED 450 participants

A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00069004

COMPLETED Phase 2 342 participants

Changing to Nonprotease Inhibitor Treatment to Improve Side Effects

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00021463

COMPLETED 257 participants

Lipodystrophy Connect Patient Registry

PatientCrossroads

NCT02577952

COMPLETED NA 150 participants

Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV Patients

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00028314

COMPLETED Phase 2 50 participants

Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00119379

COMPLETED NA 44 participants

Exercise and Pioglitazone for HIV-Metabolic Syndromes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00639457

COMPLETED Phase 1 16 participants

Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy Volunteers

Topokine Therapeutics

NCT02647853

COMPLETED Phase 2 5 participants

Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02639286

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Lipodystrophy Trial Landscape

ClinicalTrials.gov lists 12 US studies indexed under Lipodystrophy, and 2 of those are currently open to recruitment — roughly 17% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Lipodystrophy shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Lipodystrophy is led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) with 6 indexed trials, alongside 3 other organizations in the top contributor list. The list on this page surfaces up to 12 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Lipodystrophy?

PlainTrial tracks 12 US clinical trials for Lipodystrophy, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Lipodystrophy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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