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ClinicalTrials.gov 2 recruiting now official registry

Lipodystrophy clinical trials

2 of 12 indexed Lipodystrophy trials are currently recruiting.

12 US clinical trials · 2 currently recruiting

Lipodystrophy is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), running 6 of these trials.

The research picture

Lipodystrophy has 12 registered US clinical trials, 2 of them open to new participants right now, about 17% of the total.

2
recruiting participants now
17%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
6
top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phase 11Phase 24Phase 31

Active & Recent Trials

12 total, page 1 of 1

RECRUITING 90 participants

Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05419037

RECRUITING 14 participants

Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05996536

ACTIVE NOT RECRUITING Phase 2 29 participants

Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02262806

ACTIVE NOT RECRUITING Phase 3 24 participants

Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02262832

COMPLETED 450 participants

A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00069004

COMPLETED Phase 2 342 participants

Changing to Nonprotease Inhibitor Treatment to Improve Side Effects

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00021463

COMPLETED 257 participants

Lipodystrophy Connect Patient Registry

PatientCrossroads

NCT02577952

COMPLETED NA 150 participants

Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV Patients

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00028314

COMPLETED Phase 2 50 participants

Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00119379

COMPLETED NA 44 participants

Exercise and Pioglitazone for HIV-Metabolic Syndromes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00639457

COMPLETED Phase 1 16 participants

Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy Volunteers

Topokine Therapeutics

NCT02647853

COMPLETED Phase 2 5 participants

Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02639286

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Lipodystrophy Trial Landscape

12 indexed Lipodystrophy studies · 2 recruiting (17%).

Phase mix: 1 late (III/IV) vs 5 early (I/II).

Top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (6 trials), 3 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Lipodystrophy?

PlainTrial tracks 12 US clinical trials for Lipodystrophy, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Lipodystrophy?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.