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ClinicalTrials.gov 1 recruiting now official registry

Liver Disease clinical trials

Every US clinical trial registered for Liver Disease — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

15 US clinical trials · 1 currently recruiting

The research picture

Liver Disease has 15 registered US clinical trials, 1 of them open to new participants right now — about 7% of the total.

1
recruiting participants now
7%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
5
top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 8,050 participants

Evaluation of Patients With Liver Disease

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00001971

ACTIVE NOT RECRUITING 154 participants

Genetic Modifiers of Cystic Fibrosis (CF) Liver Disease

University of North Carolina, Chapel Hill

NCT00804583

COMPLETED 1,247 participants

Quantitative Evaluation of the Progression of Liver Disease, Using ShearWaveTM

Baylor Research Institute

NCT02070315

COMPLETED 870 participants

Genetics of Hepatitis C Virus Infection

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00005657

COMPLETED 401 participants

Pediatric Liver Database

Medical College of Wisconsin

NCT00677625

COMPLETED Phase 2 124 participants

Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016)

Merck Sharp & Dohme

NCT06482112

COMPLETED 53 participants

Dynamic Post-Prandial Metabolism in Patients With Non-Alcoholic Fatty Liver Disease

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02520609

COMPLETED Phase 4 50 participants

Prospective Validation of a Plasma Transfusion Dosing Algorithm in Patients With Chronic Liver Disease

University of Colorado, Denver

NCT02366845

COMPLETED Phase 1 45 participants

Hepatic Impairment Study

Bayer

NCT00829231

COMPLETED 32 participants

Comparing Pain in Patients Undergoing Percutaneous Versus Transjugular Techniques of Liver Biopsy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02311348

COMPLETED Phase 1 30 participants

Elafibranor Pharmacokinetic Parameters in Hepatic Impaired Patients

Genfit

NCT03765671

COMPLETED Phase 1 26 participants

Study to Compare Conivaptan in Subjects With Mild & Moderate Liver Impairment Versus Subjects With Normal Liver Function

Cumberland Pharmaceuticals

NCT00851227

COMPLETED Phase 1 24 participants

A Phase 1 Study to Compare the PK and Safety of Naproxcinod in Hepatic Impaired Patients and Matching Healthy Subjects

NicOx

NCT00621881

COMPLETED 17 participants

Non-invasive Biomarkers of Fibrosis in Pediatric Liver Diseases

Baylor College of Medicine

NCT01988753

COMPLETED Phase 3 15 participants

Gabapentin to Treat Itch in Patients With Liver Disease

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00058890

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 1
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Liver Disease Trial Landscape

ClinicalTrials.gov lists 15 US studies indexed under Liver Disease, and 1 of those are currently open to recruitment — roughly 7% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Liver Disease shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Liver Disease is led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 15 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Liver Disease?

PlainTrial tracks 15 US clinical trials for Liver Disease, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Liver Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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