National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

490 total trials 50 currently recruiting 398 completed

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors 490 registered US clinical trials on ClinicalTrials.gov, 50 of them currently recruiting, and 398 completed. 69 of these trials are in Phase 3-4 (later-stage) and 178 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 25 trials.

Trial Pipeline

490 total, page 2 of 10

ACTIVE NOT RECRUITING Phase 2

Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes

NCT03929601

ACTIVE NOT RECRUITING Phase 2

Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)

NCT05743244

ACTIVE NOT RECRUITING Phase 4

People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents

NCT03520660

ACTIVE NOT RECRUITING Phase 2

Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy

NCT02262806

ACTIVE NOT RECRUITING Phase 3

Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy

NCT02262832

ACTIVE NOT RECRUITING Phase 2

Effect of Metreleptin Therapy in the Treatment of Severe Insulin Resistance

NCT00085982

NOT YET RECRUITING Phase 2

Platform Trial in Stage 1 Diabetes: Comparing Golimumab vs Placebo

NCT07683026

NOT YET RECRUITING Phase 2

Platform Trial to Delay Stage 3 Diabetes: Comparing Teplizumab With ATG

NCT07216391

NOT YET RECRUITING Phase 1

177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer

NCT06991738

NOT YET RECRUITING

Evaluation of the Clinical Spectrum of Diabetes and Obesity in Youth and Adults

NCT07388537

NOT YET RECRUITING

Prevalence and Development of Liver Dysfunction in Hematopoietic Stem Cell Transplant

NCT05722210

NOT YET RECRUITING Phase 2

Effects of Meal Macronutrients on Postprandial Lipids

NCT07313787

NOT YET RECRUITING Phase 2

Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity

NCT05713799

NOT YET RECRUITING

Assessing the Impact of Perceptions of Unpredictability on Objective Measures of Food Consumption and Metabolism

NCT06690294

NOT YET RECRUITING

Discovering Determinants of Food Intake by Application of Artificial Intelligence to Complex, High-Dimensional Data

NCT07637656

NOT YET RECRUITING

Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease

NCT07619547

TERMINATED Phase 2

STOP-T1D Low-Dose (ATG)

NCT04291703

COMPLETED

Study to Determine the Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects With Chronic Liver Disease

NCT05669677

COMPLETED NA

Effect of Ultra-processed Versus Unprocessed Diets on Energy Metabolism

NCT05290064

COMPLETED

The Impact of the COVID-19 Pandemic on Eating Behavior and Weight Change

NCT04896060

COMPLETED Phase 2

Vitamin E Dosing Study

NCT04801849

COMPLETED Phase 2

HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis

NCT04571619

COMPLETED Phase 1

A Multiple Ascending Dose Trial Investigating Safety, Tolerability and Pharmacokinetics of NNC0361-0041

NCT04279613

COMPLETED Phase 2

Prebiotics and Metformin Improve Gut and Hormones in Type 2 Diabetes in Youth (MIGHTY-fiber)

NCT04209075

COMPLETED Phase 1

Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

NCT02107976

COMPLETED NA

Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism

NCT03878108

TERMINATED Phase 2

Losartan for the Treatment of Pediatric NAFLD

NCT03467217

COMPLETED Early Phase 1

Brain Dopamine Function in Human Obesity

NCT03648892

TERMINATED Phase 2

Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes Mellitus

NCT03428945

COMPLETED Phase 2

Treatment of Chronic Delta Hepatitis With Lonafarnib, Ritonavir and Lambda Interferon

NCT03600714

COMPLETED NA

Effect of Ultra Processed Versus Unprocessed Diets on Energy Intake

NCT03407053

COMPLETED

Effect of Isocaloric Ultra Processed Versus Unprocessed Diets on Insulin Sensitivity

NCT03189121

COMPLETED

Hepatitis B Reactivation During Treatment With Direct-Acting Antiviral Agents for Chronic Hepatitis C Infection

NCT03248622

COMPLETED Phase 1

Title: Therapeutic Targets in African-American Youth With Type 2 Diabetes

NCT02960659

COMPLETED NA

Food Intake Response to Short-Term Modifications of Metabolism in Humans

NCT02939404

COMPLETED

Longitudinal Assessment of Transient Elastography in Cystic Fibrosis

NCT03001388

COMPLETED

MRI to Characterize and Predict CF Liver Disease in PUSH Cohort

NCT02979340

COMPLETED

Optimizing HBV Care Cascade Among Foreign-Born in the United States (FOCUS-HBV Study)

NCT05621304

COMPLETED Phase 1

A Phase 1 Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ManNAc in Subjects With Primary Podocyte Diseases

NCT02639260

COMPLETED Phase 2

Immune Effects of Oral Insulin in Relatives at Risk for Type 1 Diabetes Mellitus (TN20)

NCT02580877

COMPLETED Phase 2

Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension

NCT02639286

COMPLETED

Dynamic Post-Prandial Metabolism in Patients With Non-Alcoholic Fatty Liver Disease

NCT02520609

COMPLETED

Quantifying the Persistence of Metabolic Adaptation and Weight Regain Following Extreme Weight Loss

NCT02544009

COMPLETED Phase 2

Treatment of Chronic Delta Hepatitis With Lonafarnib and Ritonavir

NCT02511431

COMPLETED Phase 2

Viral Kinetics, Interferon Stimulated Genes (ISGs) and mirRNA Among Subjects Infected With Different Hepatitis C Virus Genotypes During Therapy With Sofosbuvir and GS-5816

NCT02468648

COMPLETED

Deciphering the Mechanisms Involved in Microbial Translocation Across the Spectrum of HCV Associated Liver Fibrosis

NCT02400216

COMPLETED Phase 2

Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in People With Insulin Receptor Mutations

NCT02457897

COMPLETED

Palmitate Breath Test to Assess Fatty Acid Oxidation in Non Alcoholic Fatty Liver Disease (NAFLD)

NCT02363309

COMPLETED Phase 2

Add-on Peginterferon Following Nucleos(t)Ide Analogue Treatment

NCT02364336

COMPLETED

Cross Calibration of Two Dual Energy Densitometers and Comparison of Regional Adipose Tissue Measurements by iDXA and MRI

NCT02346474

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 136
Phase 3 55
Phase 4 14

What the Pipeline for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Shows

According to the ClinicalTrials.gov registry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is linked to 490 US clinical trials across every stage of research activity. Of those, 50 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 398 are already marked complete, representing roughly 81% of the total.

The phase mix for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) reports 69 late-stage studies (Phase 3 and Phase 4 combined) and 178 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is Obesity with 25 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.