Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Hepatitis C
Open-data reference.
105 US clinical trials · 13 currently recruiting
Active & Recent Trials
Evaluation of Patients With Liver Disease
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00001971
The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing
University of Chicago
NCT01280825
Proteogenomic Monitoring and Assessment of Liver Transplant Recipients
Northwestern University
NCT01644903
Blood Collection Biorepository for Liver Disease Research
State University of New York at Buffalo
NCT03025074
The HOPE Study: Characterizing Patients With Hepatitis B and C
University of Maryland, Baltimore
NCT02995252
Partner Navigation Intervention for Hepatitis C Treatment Among Young People Who Inject Drugs
University of California, San Francis
NCT06179498
The Hepatitis C Transplant Collaborative
Baylor Research Institute
NCT04493385
Project I Test: Implementing HIV Testing in Opioid Treatment Programs
Columbia University
NCT03135886
Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum
Johns Hopkins University
NCT04162938
DBS TaT in Peer-assisted Telemedicine for Hepatitis C
Oregon Health and Science University
NCT06409169
The Treatment in Pregnancy for Hepatitis C ("TiP-HepC") Registry
The Task Force for Global Health
NCT05368974
Feasibility and Acceptability of HCV Treatment in Pregnancy
Washington University School of Medicine
NCT06367465
HCV Tappt Adherence Study
University of Illinois at Chicago
NCT06263829
A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients
Mayo Clinic
NCT04508907
Tele-Harm Reduction
University of Miami
NCT05208697
Advanced Care Coordination and Enhanced Linkage and Retention Among Transitional Re-Entrants
Montefiore Medical Center
NCT04701437
The Use of Hepatitis C Positive Kidneys in Hepatitis C Negative Kidney Transplant Recipients
Amit D Tevar, MD
NCT03809533
Buprenorphine Integration Research and Community Health
Yale University
NCT05668780
Expanding the Pool in Orthotopic Heart Transplantation
Mary E. Keebler, MD
NCT03222531
The DETECT HCV Screening Trial
Denver Health and Hospital Authority
NCT04003454
HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network
University of North Carolina, Chapel Hill
NCT01474811
Improving Inpatient Screening for Hepatitis C
University of Pennsylvania
NCT04525690
Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir and Sofosbuvir/Velpatasvir in Adults With Chronic HCV Infection Who Have Not Previously Received Treatment With Direct-Acting Antiviral Therapy
Gilead Sciences
NCT02607800
Genetics of Hepatitis C Virus Infection
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00005657
An Observational Study of Hepatitis C Virus in Pregnancy
The George Washington University Biostatistics Center
NCT01959321
Patient-Centered Models of HCV Care for People Who Inject Drugs
Prisma Health-Upstate
NCT02824640
Long Term Follow-up Study to Assess Durability of Sustained Virologic Response in Alisporivir-treated Hepatitis C Patients
Debiopharm International
NCT02753699
Efficacy and Safety of BI 201335 (Faldaprevir) in Combination With Pegylated Interferon-alpha and Ribavirin in Treatment-naïve Genotype 1 Hepatitis C Infected Patients (STARTverso 2)
Boehringer Ingelheim
NCT01297270
Does Induction PEG-Intron in Combination With Rebetol Enhance the Sustained Response Rates in Patients With CHC
Brooke Army Medical Center
NCT00207363
Study Comparing Daclatasvir (BMS-790052) With Telaprevir Combined With Peginterferon Alfa-2a and Ribavirin in Patients With Chronic Hepatitis C Virus Infection
Bristol-Myers Squibb
NCT01492426
SOF (Sovaldi®) +RBV for 16 or 24 Weeks and SOF+RBV+Peg-IFN for 12 Weeks in Adults With Genotype 2 or 3 Chronic HCV Infection
Gilead Sciences
NCT01962441
Long-Term Study of Liver Disease in People With Hepatitis B and/or Hepatitis C With or Without HIV Infection
National Institutes of Health Clinical Center (CC)
NCT01350648
Phase 3 Study of Sofosbuvir and Ribavirin
Gilead Sciences
NCT01497366
Integrating HIV and Hepatitis C Screening in an Urban Emergency Department
New York City Health and Hospitals Corporation
NCT03252483
Efficacy and Safety of Adding Alisporivir (DEB025) to Peginterferon (IFN) Alfa-2a (Peg-IFN Alfa-2a) and Ribavirin in Chronic HCV Genotype 1 Patients Who Relapsed or Did Not Respond to Previous Treatment
Debiopharm International
NCT01183169
Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir in Adults With Chronic HCV Infection Who Have Previously Received Treatment With Direct-Acting Antiviral Therapy
Gilead Sciences
NCT02607735
Virology Follow up Study in Subjects Previously Treated With Telaprevir
Vertex Pharmaceuticals Incorporated
NCT00916474
Hepatitis C Antiviral Resistance in African-Americans
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00038974
Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT03512210
An Efficacy, Safety and Tolerability Study of TMC435 in Genotype 1 Hepatitis C-infected Patients Who Relapsed After Previous Therapy
Janssen R&D Ireland
NCT01281839
The Kentucky Viral Hepatitis Treatment Study
Jennifer Havens
NCT03949764
Collection of Plasma and Serum Samples From Individuals Initiating Sofosbuvir for Chronic Hepatitis C for Testing
Hologic
NCT02068963
Brain Deficits in HIV/HCV Coinfected People Before and After Anti-HCV Therapy
University of California, Los Angeles
NCT00747539
Integrated Stepped Care for Unhealthy Alcohol Use in HIV
Yale University
NCT01410123
Merimepodib (MMPD) in Triple Combination for the Treatment of Chronic Hepatitis C
Vertex Pharmaceuticals Incorporated
NCT00088504
Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection
Baylor Research Institute
NCT00163657
Hepatitis C Translating Initiatives for Depression Into Effective Solutions
VA Office of Research and Development
NCT01143896
Comparing Brief Alcohol Interventions For HIV-HCV Co-infected Persons
Butler Hospital
NCT02316184
A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV
Atea Pharmaceuticals
NCT05904470
A Study Evaluating the Safety and Clinical Activity of HCV-796 in Treatment-Naive and Non-Responder Subjects
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00367887
Antiviral & Antifibrotic Liver Therapy in HCV + Drinkers and Non-Drinkers
Icahn School of Medicine at Mount Sinai
NCT00211848
Development and Pilot Testing of a PHCI for Emergency Department Patients Who Decline Rapid HIV/ HCV Screening
Rhode Island Hospital
NCT04137094
Phase III Daclatasvir and Sofosbuvir for Genotype 3 Chronic HCV
Bristol-Myers Squibb
NCT02032901
Safety Study of Pegylated Interferon Lambda Plus Single or 2 Direct Antiviral Agents With Ribavirin
Bristol-Myers Squibb
NCT01795911
Safety Study of Pegylated Interferon Lambda Plus Single or 2 Direct Antiviral Agents With Ribavirin
Bristol-Myers Squibb
NCT01309932
Infliximab Treatment Along With Pegylated Interferon and Ribavirin in the Treatment of Hepatitis C
Nizar Zein
NCT00512278
Prevention of De Novo HCV With Antiviral HCV Therapy Post-Liver and Post-Kidney Transplant
University of California, San Francis
NCT03619837
A Rollover Study of BI 201335 in Combination With Pegylated Interferon-alpha and Ribavirin in Treatment-experienced Genotype 1 Hepatitis C Infected Patients
Boehringer Ingelheim
NCT01330316
A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to Therapy
Vertex Pharmaceuticals Incorporated
NCT00535847
Safety and Efficacy Study to Compare Continuous Infusion of Interferon With Standard of Care for Chronic Hepatitis C
Medtronic Corporate Technologies and New Ventures
NCT00919633
A Study of Albuferon With Ribavirin in Interferon Treatment Experienced Subjects With Chronic Hepatitis C
Human Genome Sciences
NCT00097435
Hepatitis C Education for Pregnant Women With Opiate Dependence - Phase 2
TriHealth
NCT03320889
TD-6450 SAD and MAD in Healthy Subjects
Theravance Biopharma
NCT02022306
Anticipated and Perceived Benefits Following Hepatitis C Treatment
University of North Carolina, Chapel Hill
NCT03000023
HCV Group Evaluation and Treatment Uptake (HCV GET-UP) Intervention
Montefiore Medical Center
NCT03242655
Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes After Hepatitis C Eradication
University of Maryland, Baltimore
NCT03823911
SB497115 (Oral Thrombopoietin Receptor Agonist) Versus Placebo In Adults With Thrombocytopenia Due To Hepatitis C
GlaxoSmithKline
NCT00110799
The Use of Hepatitis C Positive Livers in Hepatitis C Negative Liver Transplant Recipients
Fernanda P Silveira, MD, MS
NCT03819322
Evaluation of HepCure Toolkit to Improve Harvoni Adherence
Icahn School of Medicine at Mount Sinai
NCT02740556
Helping Empower Liver and Kidney Patients
Washington University School of Medicine
NCT03426787
Study of CTS-1027 in Combination With Pegylated Interferon and Ribavirin in Hepatitis C Virus (HCV) Null-Responders
Conatus Pharmaceuticals
NCT01051921
Efficacy of Sofosbuvir With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant
Gilead Sciences
NCT01559844
GS-7977 With Ribavirin for Hepatitis C (SPARE)
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01441180
History of Hepatitis C in Volunteer Blood Donors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00001982
Phase I Trial of Silymarin for Chronic Liver Diseases
National Center for Complementary and Integrative Health (NCCIH)
NCT00389376
Single and Multiple Dose Evaluation of ABT-072 and to Evaluate the Effect of Food on the Pharmacokinetics of ABT-072
Abbott
NCT00982826
Eliminating Hepatitis C Virus
Icahn School of Medicine at Mount Sinai
NCT03401697
Study of FK788 in Subjects With Chronic Hepatitis C Virus Infection
Astellas Pharma
NCT00047814
Sofosbuvir (GS-7977) in Combination With PEG and Ribavirin for 12 Weeks in Treatment Experienced Subjects With Chronic HCV Infection Genotype 2 or 3
Gilead Sciences
NCT01808248
TD-6450 MAD Study in HCV Infected Subjects
Theravance Biopharma
NCT02116543
Preventing Depression in Methadone Maintenance Patients Receiving Hepatitis C Treatment - 1
National Institute on Drug Abuse (NIDA)
NCT00218556
Drug Interaction Study Between Eltrombopag and Lopinavir/Ritonavir in Healthy Adult Subjects.
GlaxoSmithKline
NCT00833378
HCV Seek, Test and Rapid Treatment for Young PWID
Weill Medical College of Cornell University
NCT03627546
New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01888900
Study of Bavituximab in Patients With Chronic Hepatitis C Virus Infection
Peregrine Pharmaceuticals
NCT00128271
Interaction of Alcohol and Highly Active Antiretroviral Therapy (HAART) in HIV/AIDS and HIV/AIDS With Hepatitis C Virus (HCV) Co-Infection
University of California, San Francis
NCT00879047
Evaluating the Safety of ITX 5061 in Treatment-Naive Hepatitis C (HCV)-Infected Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01165359
Determining Responses to Two Different Vaccines in HIV and HCV Infected Individuals
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00393276
Proof of Concept Study for Safety and Efficacy of EDP239 in Hepatitis C Subjects
Enanta Pharmaceuticals
NCT01856426
Potential for Drug-drug Interactions Between Boceprevir and Etravirine in HIV/Hepatitis C Virus Negative Volunteers
University of Colorado, Denver
NCT01427504
Rapid Hepatitis C Elimination Trial- A Pilot Study of Daclatasvir/Asunaprevir/BMS-791325 With or Without Ribavirin To Treat Hepatitis C Virus
Timothy Morgan, MD
NCT02098616
Open-Label Hepatic Impairment Study
Gilead Sciences
NCT01497327
Treatment of Hepatitis C in Hemophilic Patients With HIV
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00055341
Treatment of Acute Hepatitis C Virus in HIV Co-Infection
University of California, San Francis
NCT00845676
Cross-Over Study to Assess the Cardiovascular Effects of GSK2336805
GlaxoSmithKline
NCT01424540
A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults
Vertex Pharmaceuticals Incorporated
NCT01038167
Non-invasive Biomarkers of Fibrosis in Pediatric Liver Diseases
Baylor College of Medicine
NCT01988753
Dose Finding Trial of Rosuvastatin and Atorvastatin Versus Hepatitis C
Bader, Ted, M.D.
NCT00446940
Characterization of Clonal B Cell Populations in HCV Infection
Rockefeller University
NCT00435201
Study of the Immune Response to Hepatitis C Virus
Rockefeller University
NCT00237432
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 14 |
| Phase 2 | 23 |
| Phase 3 | 11 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Hepatitis C Trial Landscape
ClinicalTrials.gov lists 105 US studies indexed under Hepatitis C, and 13 of those are currently open to recruitment — roughly 12% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Hepatitis C shows 20 late-stage studies (Phase 3 and Phase 4 combined) alongside 37 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Hepatitis C is led by Gilead Sciences with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Hepatitis C?
PlainTrial tracks 105 US clinical trials for Hepatitis C, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Hepatitis C?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.