Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Hepatitis C

Open-data reference.

105 US clinical trials · 13 currently recruiting

Active & Recent Trials

RECRUITING 8,050 participants

Evaluation of Patients With Liver Disease

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00001971

RECRUITING 1,200 participants

The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing

University of Chicago

NCT01280825

RECRUITING 1,000 participants

Proteogenomic Monitoring and Assessment of Liver Transplant Recipients

Northwestern University

NCT01644903

RECRUITING 1,000 participants

Blood Collection Biorepository for Liver Disease Research

State University of New York at Buffalo

NCT03025074

RECRUITING 550 participants

The HOPE Study: Characterizing Patients With Hepatitis B and C

University of Maryland, Baltimore

NCT02995252

RECRUITING NA 500 participants

Partner Navigation Intervention for Hepatitis C Treatment Among Young People Who Inject Drugs

University of California, San Francis

NCT06179498

RECRUITING 500 participants

The Hepatitis C Transplant Collaborative

Baylor Research Institute

NCT04493385

RECRUITING NA 418 participants

Project I Test: Implementing HIV Testing in Opioid Treatment Programs

Columbia University

NCT03135886

RECRUITING NA 308 participants

Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum

Johns Hopkins University

NCT04162938

RECRUITING NA 141 participants

DBS TaT in Peer-assisted Telemedicine for Hepatitis C

Oregon Health and Science University

NCT06409169

RECRUITING 100 participants

The Treatment in Pregnancy for Hepatitis C ("TiP-HepC") Registry

The Task Force for Global Health

NCT05368974

RECRUITING 50 participants

Feasibility and Acceptability of HCV Treatment in Pregnancy

Washington University School of Medicine

NCT06367465

RECRUITING NA 30 participants

HCV Tappt Adherence Study

University of Illinois at Chicago

NCT06263829

ACTIVE NOT RECRUITING Phase 4 200 participants

A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients

Mayo Clinic

NCT04508907

ACTIVE NOT RECRUITING NA 100 participants

Tele-Harm Reduction

University of Miami

NCT05208697

ACTIVE NOT RECRUITING NA 80 participants

Advanced Care Coordination and Enhanced Linkage and Retention Among Transitional Re-Entrants

Montefiore Medical Center

NCT04701437

ACTIVE NOT RECRUITING Phase 2 30 participants

The Use of Hepatitis C Positive Kidneys in Hepatitis C Negative Kidney Transplant Recipients

Amit D Tevar, MD

NCT03809533

ACTIVE NOT RECRUITING NA 20 participants

Buprenorphine Integration Research and Community Health

Yale University

NCT05668780

ACTIVE NOT RECRUITING Phase 2 20 participants

Expanding the Pool in Orthotopic Heart Transplantation

Mary E. Keebler, MD

NCT03222531

COMPLETED NA 147,533 participants

The DETECT HCV Screening Trial

Denver Health and Hospital Authority

NCT04003454

COMPLETED 13,559 participants

HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network

University of North Carolina, Chapel Hill

NCT01474811

COMPLETED NA 7,634 participants

Improving Inpatient Screening for Hepatitis C

University of Pennsylvania

NCT04525690

COMPLETED Phase 3 943 participants

Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir and Sofosbuvir/Velpatasvir in Adults With Chronic HCV Infection Who Have Not Previously Received Treatment With Direct-Acting Antiviral Therapy

Gilead Sciences

NCT02607800

COMPLETED 870 participants

Genetics of Hepatitis C Virus Infection

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00005657

COMPLETED 772 participants

An Observational Study of Hepatitis C Virus in Pregnancy

The George Washington University Biostatistics Center

NCT01959321

COMPLETED NA 755 participants

Patient-Centered Models of HCV Care for People Who Inject Drugs

Prisma Health-Upstate

NCT02824640

COMPLETED Phase 3 723 participants

Long Term Follow-up Study to Assess Durability of Sustained Virologic Response in Alisporivir-treated Hepatitis C Patients

Debiopharm International

NCT02753699

COMPLETED Phase 3 658 participants

Efficacy and Safety of BI 201335 (Faldaprevir) in Combination With Pegylated Interferon-alpha and Ribavirin in Treatment-naïve Genotype 1 Hepatitis C Infected Patients (STARTverso 2)

Boehringer Ingelheim

NCT01297270

COMPLETED Phase 4 610 participants

Does Induction PEG-Intron in Combination With Rebetol Enhance the Sustained Response Rates in Patients With CHC

Brooke Army Medical Center

NCT00207363

COMPLETED Phase 3 605 participants

Study Comparing Daclatasvir (BMS-790052) With Telaprevir Combined With Peginterferon Alfa-2a and Ribavirin in Patients With Chronic Hepatitis C Virus Infection

Bristol-Myers Squibb

NCT01492426

COMPLETED Phase 3 601 participants

SOF (Sovaldi®) +RBV for 16 or 24 Weeks and SOF+RBV+Peg-IFN for 12 Weeks in Adults With Genotype 2 or 3 Chronic HCV Infection

Gilead Sciences

NCT01962441

COMPLETED 569 participants

Long-Term Study of Liver Disease in People With Hepatitis B and/or Hepatitis C With or Without HIV Infection

National Institutes of Health Clinical Center (CC)

NCT01350648

COMPLETED Phase 3 527 participants

Phase 3 Study of Sofosbuvir and Ribavirin

Gilead Sciences

NCT01497366

COMPLETED NA 478 participants

Integrating HIV and Hepatitis C Screening in an Urban Emergency Department

New York City Health and Hospitals Corporation

NCT03252483

COMPLETED Phase 2 459 participants

Efficacy and Safety of Adding Alisporivir (DEB025) to Peginterferon (IFN) Alfa-2a (Peg-IFN Alfa-2a) and Ribavirin in Chronic HCV Genotype 1 Patients Who Relapsed or Did Not Respond to Previous Treatment

Debiopharm International

NCT01183169

COMPLETED Phase 3 416 participants

Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir in Adults With Chronic HCV Infection Who Have Previously Received Treatment With Direct-Acting Antiviral Therapy

Gilead Sciences

NCT02607735

COMPLETED 408 participants

Virology Follow up Study in Subjects Previously Treated With Telaprevir

Vertex Pharmaceuticals Incorporated

NCT00916474

COMPLETED Phase 3 401 participants

Hepatitis C Antiviral Resistance in African-Americans

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00038974

COMPLETED Phase 4 400 participants

Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

NCT03512210

COMPLETED Phase 3 394 participants

An Efficacy, Safety and Tolerability Study of TMC435 in Genotype 1 Hepatitis C-infected Patients Who Relapsed After Previous Therapy

Janssen R&D Ireland

NCT01281839

COMPLETED Phase 4 374 participants

The Kentucky Viral Hepatitis Treatment Study

Jennifer Havens

NCT03949764

COMPLETED 352 participants

Collection of Plasma and Serum Samples From Individuals Initiating Sofosbuvir for Chronic Hepatitis C for Testing

Hologic

NCT02068963

COMPLETED 330 participants

Brain Deficits in HIV/HCV Coinfected People Before and After Anti-HCV Therapy

University of California, Los Angeles

NCT00747539

COMPLETED NA 319 participants

Integrated Stepped Care for Unhealthy Alcohol Use in HIV

Yale University

NCT01410123

COMPLETED Phase 2 315 participants

Merimepodib (MMPD) in Triple Combination for the Treatment of Chronic Hepatitis C

Vertex Pharmaceuticals Incorporated

NCT00088504

COMPLETED Phase 4 312 participants

Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection

Baylor Research Institute

NCT00163657

COMPLETED NA 309 participants

Hepatitis C Translating Initiatives for Depression Into Effective Solutions

VA Office of Research and Development

NCT01143896

COMPLETED NA 300 participants

Comparing Brief Alcohol Interventions For HIV-HCV Co-infected Persons

Butler Hospital

NCT02316184

COMPLETED Phase 2 275 participants

A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV

Atea Pharmaceuticals

NCT05904470

COMPLETED Phase 2 246 participants

A Study Evaluating the Safety and Clinical Activity of HCV-796 in Treatment-Naive and Non-Responder Subjects

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00367887

COMPLETED Phase 2 207 participants

Antiviral & Antifibrotic Liver Therapy in HCV + Drinkers and Non-Drinkers

Icahn School of Medicine at Mount Sinai

NCT00211848

COMPLETED NA 200 participants

Development and Pilot Testing of a PHCI for Emergency Department Patients Who Decline Rapid HIV/ HCV Screening

Rhode Island Hospital

NCT04137094

COMPLETED Phase 3 173 participants

Phase III Daclatasvir and Sofosbuvir for Genotype 3 Chronic HCV

Bristol-Myers Squibb

NCT02032901

COMPLETED Phase 2 165 participants

Safety Study of Pegylated Interferon Lambda Plus Single or 2 Direct Antiviral Agents With Ribavirin

Bristol-Myers Squibb

NCT01795911

COMPLETED Phase 2 165 participants

Safety Study of Pegylated Interferon Lambda Plus Single or 2 Direct Antiviral Agents With Ribavirin

Bristol-Myers Squibb

NCT01309932

COMPLETED Phase 2 146 participants

Infliximab Treatment Along With Pegylated Interferon and Ribavirin in the Treatment of Hepatitis C

Nizar Zein

NCT00512278

COMPLETED Phase 4 122 participants

Prevention of De Novo HCV With Antiviral HCV Therapy Post-Liver and Post-Kidney Transplant

University of California, San Francis

NCT03619837

COMPLETED Phase 3 119 participants

A Rollover Study of BI 201335 in Combination With Pegylated Interferon-alpha and Ribavirin in Treatment-experienced Genotype 1 Hepatitis C Infected Patients

Boehringer Ingelheim

NCT01330316

COMPLETED Phase 2 117 participants

A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to Therapy

Vertex Pharmaceuticals Incorporated

NCT00535847

COMPLETED Phase 2 116 participants

Safety and Efficacy Study to Compare Continuous Infusion of Interferon With Standard of Care for Chronic Hepatitis C

Medtronic Corporate Technologies and New Ventures

NCT00919633

COMPLETED Phase 2 115 participants

A Study of Albuferon With Ribavirin in Interferon Treatment Experienced Subjects With Chronic Hepatitis C

Human Genome Sciences

NCT00097435

COMPLETED NA 115 participants

Hepatitis C Education for Pregnant Women With Opiate Dependence - Phase 2

TriHealth

NCT03320889

COMPLETED Phase 1 111 participants

TD-6450 SAD and MAD in Healthy Subjects

Theravance Biopharma

NCT02022306

COMPLETED 100 participants

Anticipated and Perceived Benefits Following Hepatitis C Treatment

University of North Carolina, Chapel Hill

NCT03000023

COMPLETED NA 96 participants

HCV Group Evaluation and Treatment Uptake (HCV GET-UP) Intervention

Montefiore Medical Center

NCT03242655

COMPLETED Phase 4 87 participants

Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes After Hepatitis C Eradication

University of Maryland, Baltimore

NCT03823911

COMPLETED Phase 2 75 participants

SB497115 (Oral Thrombopoietin Receptor Agonist) Versus Placebo In Adults With Thrombocytopenia Due To Hepatitis C

GlaxoSmithKline

NCT00110799

COMPLETED Phase 2 73 participants

The Use of Hepatitis C Positive Livers in Hepatitis C Negative Liver Transplant Recipients

Fernanda P Silveira, MD, MS

NCT03819322

COMPLETED NA 71 participants

Evaluation of HepCure Toolkit to Improve Harvoni Adherence

Icahn School of Medicine at Mount Sinai

NCT02740556

COMPLETED NA 70 participants

Helping Empower Liver and Kidney Patients

Washington University School of Medicine

NCT03426787

COMPLETED Phase 2 67 participants

Study of CTS-1027 in Combination With Pegylated Interferon and Ribavirin in Hepatitis C Virus (HCV) Null-Responders

Conatus Pharmaceuticals

NCT01051921

COMPLETED Phase 2 61 participants

Efficacy of Sofosbuvir With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant

Gilead Sciences

NCT01559844

COMPLETED Phase 1 60 participants

GS-7977 With Ribavirin for Hepatitis C (SPARE)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01441180

COMPLETED 60 participants

History of Hepatitis C in Volunteer Blood Donors

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00001982

COMPLETED Phase 1 56 participants

Phase I Trial of Silymarin for Chronic Liver Diseases

National Center for Complementary and Integrative Health (NCCIH)

NCT00389376

COMPLETED Phase 1 52 participants

Single and Multiple Dose Evaluation of ABT-072 and to Evaluate the Effect of Food on the Pharmacokinetics of ABT-072

Abbott

NCT00982826

COMPLETED 52 participants

Eliminating Hepatitis C Virus

Icahn School of Medicine at Mount Sinai

NCT03401697

COMPLETED Phase 2 48 participants

Study of FK788 in Subjects With Chronic Hepatitis C Virus Infection

Astellas Pharma

NCT00047814

COMPLETED Phase 2 47 participants

Sofosbuvir (GS-7977) in Combination With PEG and Ribavirin for 12 Weeks in Treatment Experienced Subjects With Chronic HCV Infection Genotype 2 or 3

Gilead Sciences

NCT01808248

COMPLETED Phase 1 47 participants

TD-6450 MAD Study in HCV Infected Subjects

Theravance Biopharma

NCT02116543

COMPLETED NA 42 participants

Preventing Depression in Methadone Maintenance Patients Receiving Hepatitis C Treatment - 1

National Institute on Drug Abuse (NIDA)

NCT00218556

COMPLETED Phase 1 40 participants

Drug Interaction Study Between Eltrombopag and Lopinavir/Ritonavir in Healthy Adult Subjects.

GlaxoSmithKline

NCT00833378

COMPLETED NA 39 participants

HCV Seek, Test and Rapid Treatment for Young PWID

Weill Medical College of Cornell University

NCT03627546

COMPLETED Phase 2 35 participants

New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT01888900

COMPLETED Phase 1 32 participants

Study of Bavituximab in Patients With Chronic Hepatitis C Virus Infection

Peregrine Pharmaceuticals

NCT00128271

COMPLETED Phase 1 30 participants

Interaction of Alcohol and Highly Active Antiretroviral Therapy (HAART) in HIV/AIDS and HIV/AIDS With Hepatitis C Virus (HCV) Co-Infection

University of California, San Francis

NCT00879047

COMPLETED Phase 1 30 participants

Evaluating the Safety of ITX 5061 in Treatment-Naive Hepatitis C (HCV)-Infected Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01165359

COMPLETED Phase 1 29 participants

Determining Responses to Two Different Vaccines in HIV and HCV Infected Individuals

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00393276

COMPLETED Phase 1 28 participants

Proof of Concept Study for Safety and Efficacy of EDP239 in Hepatitis C Subjects

Enanta Pharmaceuticals

NCT01856426

COMPLETED NA 26 participants

Potential for Drug-drug Interactions Between Boceprevir and Etravirine in HIV/Hepatitis C Virus Negative Volunteers

University of Colorado, Denver

NCT01427504

COMPLETED NA 25 participants

Rapid Hepatitis C Elimination Trial- A Pilot Study of Daclatasvir/Asunaprevir/BMS-791325 With or Without Ribavirin To Treat Hepatitis C Virus

Timothy Morgan, MD

NCT02098616

COMPLETED Phase 1 24 participants

Open-Label Hepatic Impairment Study

Gilead Sciences

NCT01497327

COMPLETED Phase 2 22 participants

Treatment of Hepatitis C in Hemophilic Patients With HIV

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00055341

COMPLETED Phase 4 21 participants

Treatment of Acute Hepatitis C Virus in HIV Co-Infection

University of California, San Francis

NCT00845676

COMPLETED Phase 1 20 participants

Cross-Over Study to Assess the Cardiovascular Effects of GSK2336805

GlaxoSmithKline

NCT01424540

COMPLETED Phase 1 20 participants

A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults

Vertex Pharmaceuticals Incorporated

NCT01038167

COMPLETED 17 participants

Non-invasive Biomarkers of Fibrosis in Pediatric Liver Diseases

Baylor College of Medicine

NCT01988753

COMPLETED Phase 2 16 participants

Dose Finding Trial of Rosuvastatin and Atorvastatin Versus Hepatitis C

Bader, Ted, M.D.

NCT00446940

COMPLETED 14 participants

Characterization of Clonal B Cell Populations in HCV Infection

Rockefeller University

NCT00435201

COMPLETED 11 participants

Study of the Immune Response to Hepatitis C Virus

Rockefeller University

NCT00237432

Phase Distribution

PhaseTrial count
Early Phase 1 14
Phase 2 23
Phase 3 11
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatitis C Trial Landscape

ClinicalTrials.gov lists 105 US studies indexed under Hepatitis C, and 13 of those are currently open to recruitment — roughly 12% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hepatitis C shows 20 late-stage studies (Phase 3 and Phase 4 combined) alongside 37 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hepatitis C is led by Gilead Sciences with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatitis C?

PlainTrial tracks 105 US clinical trials for Hepatitis C, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatitis C?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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