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Cirrhosis clinical trials
Every US clinical trial registered for Cirrhosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
54 US clinical trials · 29 currently recruiting
The research picture
Cirrhosis has 54 registered US clinical trials, 29 of them open to new participants right now — about 54% of the total.
- 29
- recruiting participants now
- 54%
- of trials open to enrollment
- 7
- in Phase 3–4 (later-stage)
- 5
- top sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
VA Office of Research and Development
NCT05486572
CirrhosisRx CDS System
University of California, San Francis
NCT05967273
Blood Collection Biorepository for Liver Disease Research
State University of New York at Buffalo
NCT03025074
Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis
Can-Fite BioPharma
NCT05201404
Technology Enabled Strategies to Promote Treatment Adherence in Liver Transplant
University of Pennsylvania
NCT05260268
Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05832229
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease
Massachusetts General Hospital
NCT05998330
Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434
Vir Biotechnology
NCT05484206
Oral Health In Cirrhosis of the Liver (ORACLE)
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT06052150
Adverse Outcomes and Mortality in Liver Transplant
Mayo Clinic
NCT05477277
Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease
Virginia Commonwealth University
NCT05548452
Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury
Giuseppe Cullaro, MD
NCT06937307
Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk
Raymond Chung
NCT05028829
Statin and Beta Blocker Use in Patients With Decompensated Cirrhosis
CAMC Health System
NCT06764966
Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting
The Cleveland Clinic
NCT03121404
Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease
Zydus Therapeutics
NCT05045482
Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT06052176
Copper Supplementation in Cirrhosis
University of Washington
NCT07471542
Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias
Mayo Clinic
NCT06306963
HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease
Massachusetts General Hospital
NCT05205954
Microbiome Modulation With Prebiotics in PTSD and Cirrhosis
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT06464952
Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis
University of Michigan
NCT06932783
Empagliflozin in Patients With Cirrhosis and Ascites
Yale University
NCT05726032
Albumin Assisted Diuresis in Patients with Cirrhosis and Ascites
Anahita Rabiee MD MHS
NCT06812390
Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis
The Cleveland Clinic
NCT03225677
Affect of Melatonin on Sleep and Cognition in Cirrhosis
Weill Medical College of Cornell University
NCT07046429
A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer
Inova Health Care Services
NCT06007846
Pilot Open-Label Trial of Resistant Potato Starch in Patients With Cirrhosis and Overt Hepatic Encephalopathy
Mayo Clinic
NCT06425380
LiverSleep: A Behavioral Sleep Intervention for Patients With Cirrhosis and Insomnia
Massachusetts General Hospital
NCT07417163
The Impact of Liver Cirrhosis on Outcomes in Trauma Patients
Methodist Health System
NCT05170854
ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk
Exact Sciences Corporation
NCT05064553
Extracellular RNA Markers of Liver Disease and Cancer
Mayo Clinic
NCT02908048
Liver Cirrhosis Network Cohort Study
Northwestern University
NCT05740358
Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis
VA Office of Research and Development
NCT03654053
Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis
National Cancer Institute (NCI)
NCT02968810
Radiation Therapy in Treating Patients With Hepatocellular Carcinoma, Cholangiocarcinoma, or Liver Metastasis Who Have Impaired Liver Function
M.D. Anderson Cancer Center
NCT02626312
Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant
Davendra Sohal
NCT05027425
Defined Green Tea Catechin Extract in Preventing Liver Cancer in Participants With Cirrhosis
National Cancer Institute (NCI)
NCT03278925
Prevention of Recurrent Hepatitis B After Liver Transplantation
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00059267
The Safety/Efficacy of Rifaximin With/Without Lactulose in Participants With A History of Recurrent Hepatic Encephalopathy
Bausch Health Americas
NCT01842581
A Study of Safety and Efficacy of HPN-100 in Subjects With Cirrhosis and Episodic Hepatic Encephalopathy
Amgen
NCT00999167
Use of Methacetin Breath Test to Predict Liver Failure in Patients With Cirrhosis
Virginia Commonwealth University
NCT01157845
Defining the Mechanisms Underlying Adrenal Insufficiency in Cirrhosis
University of Virginia
NCT04642391
FMT in Cirrhosis and Hepatic Encephalopathy
VA Office of Research and Development
NCT03796598
A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury
Ocelot Bio
NCT05309200
New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01888900
Effect of Yogurt on Minimal Hepatic Encephalopathy
Medical College of Wisconsin
NCT00312078
A (M)Ulti-center, Prospective, (O)Pen Label, Uncontrolled Feasibility (S)Tudy to Assess the Safety and Effectiveness of an Automatic Low Flow (A)Scites (Alfa) Pump (I)n Patients With (C)Irrhosis and Refractory or Recurrent Ascites
Sequana Medical N.V.
NCT02400164
Deciphering the Mechanisms Involved in Microbial Translocation Across the Spectrum of HCV Associated Liver Fibrosis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT02400216
Vasoconstrictors as Alternatives to Albumin After Large-Volume Paracentesis (LVP) in Cirrhosis
US Department of Veterans Affairs
NCT00108355
Safety Study of ARQ 197 in Cirrhotic Patients With Hepatocellular Carcinoma (HCC)
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
NCT00802555
Gabapentin to Treat Itch in Patients With Liver Disease
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00058890
Ramelteon for Treatment of Insomnia in Cirrhosis
Virginia Commonwealth University
NCT03091738
Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound
Northwell Health
NCT01208311
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 13 |
| Phase 3 | 4 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cirrhosis Trial Landscape
ClinicalTrials.gov lists 54 US studies indexed under Cirrhosis, and 29 of those are currently open to recruitment — roughly 54% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Cirrhosis shows 7 late-stage studies (Phase 3 and Phase 4 combined) alongside 20 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Cirrhosis is led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 54 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cirrhosis?
PlainTrial tracks 54 US clinical trials for Cirrhosis, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cirrhosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.