National Eye Institute (NEI)
National Eye Institute (NEI) sponsors 221 registered US clinical trials on ClinicalTrials.gov, 18 of them currently recruiting, and 179 completed. 11 of these trials are in Phase 3-4 (later-stage) and 86 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Age-related Macular Degeneration, with 8 trials.
Trial Pipeline
221 total, page 3 of 5
Family Studies of Uveal Coloboma
NCT00368004
Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy
NCT00411333
Combination Daclizumab/Denileukin Diftitox to Treat Uveitis
NCT00326508
Dynamic Light Scattering to Study Crystalline Proteins in Young Normal Lenses
NCT00304967
Infliximab, Sirolimus and Daclizumab to Treat Age-Related Macular Degeneration
NCT00304954
Efalizumab to Treat Uveitis
NCT00280826
Clinical and Molecular Studies in Families With Glaucoma and Related Diseases
NCT00272363
Clinical and Genetic Studies in Families With Myopia and Related Diseases
NCT00272376
Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia
NCT00265590
Molecular Genetics of Retinal Degenerations
NCT00231010
Triamcinolone Acetonide Injections to Treat Diabetic Macular Edema
NCT00231023
Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis
NCT00130637
Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60
NCT00121589
Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study
NCT00116090
Natural History and Genetic Studies of Usher Syndrome
NCT00106743
Treatment of Diabetic Macular Edema: Triamcinolone Injections Vs. Laser Photocoagulation
NCT00105404
Steroid Injections vs. Standard Treatment for Macular Edema Due to Retinal Blood Vessel Blockage
NCT00106132
Intravitreal v. Sub-tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders
NCT00101764
Triamcinolone Acetonide Plus Laser Therapy to Treat Age-Related Macular Degeneration
NCT00100009
Visual Cortex Stimulation in Patients With Amblyopia
NCT00097162
Cyclosporine Implant for Ocular Graft-Versus-Host Disease
NCT00102583
Effects of Antioxidants on Human Macular Pigments
NCT00718653
Ranibizumab Injections to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome
NCT00089765
Immune Indicators of Uveitis
NCT00089739
Screening for Research Subjects With Anterior Segment Diseases
NCT00088348
Efficacy of Elevated CD4 Counts on CMV Retinitis
NCT00091884
Helicobacter Pylori and Dry Eye
NCT00083291
Evaluation and Treatment of Eye Complications of Vaccinia Vaccination
NCT00081835
Dynamic Light Scattering for Studying Lens Aging and Cataract Formation
NCT00081991
Daclizumab and Sirolimus to Treat Uveitis
NCT00078689
Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System
NCT00078299
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases
NCT00076271
Infliximab to Treat Non-Infectious Scleritis
NCT00075075
Digital Photography to Evaluate Dry Eye
NCT00073099
Eye Injections of Triamcinolone Acetonide for Retinal Blood Vessel Disorders
NCT00071227
Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases
NCT00357435
Daclizumab to Treat Non-Infectious Sight-Threatening Uveitis
NCT00070759
Pilot Study of Laser Photocoagulation Therapy for Diabetic Macular Edema
NCT00069056
Optical Coherence Tomography Comparative Study
NCT00069199
Pilot Study: Dynamic Light Scattering Device for Studying Early Changes in Cataract
NCT00067483
Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa
NCT00065455
Clinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A
NCT00346333
Analyses of Existing Framingham Data
NCT00342810
Investigating Age-Related Macular Degeneration
NCT00342251
Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye
NCT00063765
Effect of DHA Supplements on Macular Function in Patients With Stargardt Macular Dystrophy and Stargardt-like Macular Dystrophy
NCT00060749
Raman Scattering Spectroscopy to Measure Macular Pigment
NCT00060580
Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases
NCT00357071
Genetic Factors in Age-Related Macular Degeneration
NCT00058695
Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts
NCT00056771
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 62 |
| Phase 2 | 24 |
| Phase 3 | 11 |
Therapeutic Areas
What the Pipeline for National Eye Institute (NEI) Shows
According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 221 US clinical trials across every stage of research activity. Of those, 18 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 179 are already marked complete, representing roughly 81% of the total.
The phase mix for National Eye Institute (NEI) reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 86 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-related Macular Degeneration with 8 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.