National Eye Institute (NEI)

221 total trials 18 currently recruiting 179 completed

National Eye Institute (NEI) sponsors 221 registered US clinical trials on ClinicalTrials.gov, 18 of them currently recruiting, and 179 completed. 11 of these trials are in Phase 3-4 (later-stage) and 86 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Age-related Macular Degeneration, with 8 trials.

Trial Pipeline

221 total, page 3 of 5

TERMINATED

Family Studies of Uveal Coloboma

NCT00368004

COMPLETED Early Phase 1

Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy

NCT00411333

COMPLETED Phase 2

Combination Daclizumab/Denileukin Diftitox to Treat Uveitis

NCT00326508

COMPLETED

Dynamic Light Scattering to Study Crystalline Proteins in Young Normal Lenses

NCT00304967

COMPLETED Phase 2

Infliximab, Sirolimus and Daclizumab to Treat Age-Related Macular Degeneration

NCT00304954

COMPLETED Phase 1

Efalizumab to Treat Uveitis

NCT00280826

COMPLETED

Clinical and Molecular Studies in Families With Glaucoma and Related Diseases

NCT00272363

COMPLETED

Clinical and Genetic Studies in Families With Myopia and Related Diseases

NCT00272376

COMPLETED

Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia

NCT00265590

COMPLETED

Molecular Genetics of Retinal Degenerations

NCT00231010

COMPLETED Phase 2

Triamcinolone Acetonide Injections to Treat Diabetic Macular Edema

NCT00231023

COMPLETED Phase 2

Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis

NCT00130637

COMPLETED Phase 1

Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60

NCT00121589

COMPLETED

Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study

NCT00116090

COMPLETED

Natural History and Genetic Studies of Usher Syndrome

NCT00106743

COMPLETED Phase 3

Treatment of Diabetic Macular Edema: Triamcinolone Injections Vs. Laser Photocoagulation

NCT00105404

COMPLETED Phase 3

Steroid Injections vs. Standard Treatment for Macular Edema Due to Retinal Blood Vessel Blockage

NCT00106132

COMPLETED Phase 1

Intravitreal v. Sub-tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders

NCT00101764

COMPLETED Phase 3

Triamcinolone Acetonide Plus Laser Therapy to Treat Age-Related Macular Degeneration

NCT00100009

COMPLETED Phase 1

Visual Cortex Stimulation in Patients With Amblyopia

NCT00097162

COMPLETED Phase 1

Cyclosporine Implant for Ocular Graft-Versus-Host Disease

NCT00102583

COMPLETED NA

Effects of Antioxidants on Human Macular Pigments

NCT00718653

COMPLETED Phase 1

Ranibizumab Injections to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome

NCT00089765

COMPLETED

Immune Indicators of Uveitis

NCT00089739

COMPLETED

Screening for Research Subjects With Anterior Segment Diseases

NCT00088348

COMPLETED

Efficacy of Elevated CD4 Counts on CMV Retinitis

NCT00091884

COMPLETED

Helicobacter Pylori and Dry Eye

NCT00083291

COMPLETED Phase 2

Evaluation and Treatment of Eye Complications of Vaccinia Vaccination

NCT00081835

COMPLETED

Dynamic Light Scattering for Studying Lens Aging and Cataract Formation

NCT00081991

COMPLETED Phase 1

Daclizumab and Sirolimus to Treat Uveitis

NCT00078689

COMPLETED

Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System

NCT00078299

COMPLETED

Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases

NCT00076271

COMPLETED Phase 1

Infliximab to Treat Non-Infectious Scleritis

NCT00075075

COMPLETED

Digital Photography to Evaluate Dry Eye

NCT00073099

COMPLETED Phase 1

Eye Injections of Triamcinolone Acetonide for Retinal Blood Vessel Disorders

NCT00071227

COMPLETED

Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases

NCT00357435

COMPLETED Phase 2

Daclizumab to Treat Non-Infectious Sight-Threatening Uveitis

NCT00070759

COMPLETED Phase 1

Pilot Study of Laser Photocoagulation Therapy for Diabetic Macular Edema

NCT00069056

COMPLETED

Optical Coherence Tomography Comparative Study

NCT00069199

COMPLETED

Pilot Study: Dynamic Light Scattering Device for Studying Early Changes in Cataract

NCT00067483

COMPLETED Phase 1

Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa

NCT00065455

COMPLETED Phase 3

Clinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A

NCT00346333

COMPLETED

Analyses of Existing Framingham Data

NCT00342810

COMPLETED

Investigating Age-Related Macular Degeneration

NCT00342251

COMPLETED Phase 1

Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye

NCT00063765

COMPLETED Phase 1

Effect of DHA Supplements on Macular Function in Patients With Stargardt Macular Dystrophy and Stargardt-like Macular Dystrophy

NCT00060749

COMPLETED Phase 1

Raman Scattering Spectroscopy to Measure Macular Pigment

NCT00060580

COMPLETED

Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases

NCT00357071

TERMINATED

Genetic Factors in Age-Related Macular Degeneration

NCT00058695

COMPLETED

Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts

NCT00056771

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What the Pipeline for National Eye Institute (NEI) Shows

According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 221 US clinical trials across every stage of research activity. Of those, 18 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 179 are already marked complete, representing roughly 81% of the total.

The phase mix for National Eye Institute (NEI) reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 86 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-related Macular Degeneration with 8 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.