Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Eye Diseases

Open-data reference.

28 US clinical trials · 11 currently recruiting

Active & Recent Trials

RECRUITING 20,000,000 participants

IRIS Registry: Intelligent Research in Sight Registry

American Academy of Ophthalmology

NCT02485847

RECRUITING 10,000 participants

Screening for Research Participants

National Eye Institute (NEI)

NCT00655096

RECRUITING 1,000 participants

Adaptive Optics Retinal Imaging

National Eye Institute (NEI)

NCT02317328

RECRUITING NA 900 participants

Michigan Screening and Intervention for Glaucoma and Eye Health Through Telemedicine (SIGHT) 2

University of Michigan

NCT06934577

RECRUITING 500 participants

Assessment of the Ocular Microbiome in Health and Disease

Vanderbilt University Medical Center

NCT05414994

RECRUITING Phase 2 75 participants

Extension Study of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

Sling Therapeutics

NCT06112340

RECRUITING Phase 2 70 participants

SGLT2 Inhibitors in Geographic Atrophy

Washington University School of Medicine

NCT07174687

RECRUITING 42 participants

Widefield Confocal Scanning Laser Ophthalmoscope Optimized for Pediatric and Neonatal Imaging

Duke University

NCT06177639

RECRUITING Phase 4 40 participants

Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work

Southern College of Optometry

NCT07266948

RECRUITING Phase 3 32 participants

Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)

Laboratoires Thea

NCT06891443

RECRUITING Phase 1 12 participants

MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby)

PYC Therapeutics

NCT06455826

ACTIVE NOT RECRUITING NA 749 participants

Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)

Columbia University

NCT04271709

ACTIVE NOT RECRUITING 250 participants

Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study

Complement Therapeutics

NCT05797896

ACTIVE NOT RECRUITING 103 participants

Rate of Progression in EYS Related Retinal Degeneration

Jaeb Center for Health Research

NCT04127006

ACTIVE NOT RECRUITING Phase 2 90 participants

A Phase 2b, Study of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

Sling Therapeutics

NCT05276063

ACTIVE NOT RECRUITING Phase 2 36 participants

A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)

ProQR Therapeutics

NCT03913143

ACTIVE NOT RECRUITING 18 participants

Non-Interventional Long Term Follow-up Study of Participants Previously Enrolled in the RESTORE Study

Nanoscope Therapeutics

NCT06162585

ACTIVE NOT RECRUITING Phase 1 11 participants

A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene

ProQR Therapeutics

NCT04123626

COMPLETED Phase 3 362 participants

Phase 3 Safety Study for the Treatment of Presbyopia Subjects

LENZ Therapeutics

NCT05753189

COMPLETED 350 participants

Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases

National Eye Institute (NEI)

NCT00076271

COMPLETED 219 participants

Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases

National Eye Institute (NEI)

NCT00357071

COMPLETED 88 participants

Triton Agreement and Precision Study

Topcon Medical Systems

NCT03080714

COMPLETED Phase 2 70 participants

Anecortave Acetate for Treatment of Steroid Induced Intraocular Pressure (IOP) Elevation

Alcon Research

NCT00315640

COMPLETED Phase 2 68 participants

Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia

LENZ Therapeutics

NCT05294328

COMPLETED Phase 2 27 participants

Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE]

Nanoscope Therapeutics

NCT04945772

COMPLETED 26 participants

Natural History Study of CEP290-Related Retinal Degeneration

Editas Medicine

NCT03396042

COMPLETED Phase 1 24 participants

Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy

Pfizer

NCT01003691

COMPLETED Phase 3 14 participants

Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD

Novartis Pharmaceuticals

NCT03954626

Phase Distribution

PhaseTrial count
Early Phase 1 3
Phase 2 7
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Eye Diseases Trial Landscape

ClinicalTrials.gov lists 28 US studies indexed under Eye Diseases, and 11 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Eye Diseases shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 10 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Eye Diseases is led by National Eye Institute (NEI) with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 28 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Eye Diseases?

PlainTrial tracks 28 US clinical trials for Eye Diseases, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Eye Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →