National Eye Institute (NEI)

221 total trials 18 currently recruiting 179 completed

National Eye Institute (NEI) sponsors 221 registered US clinical trials on ClinicalTrials.gov, 18 of them currently recruiting, and 179 completed. 11 of these trials are in Phase 3-4 (later-stage) and 86 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Age-related Macular Degeneration, with 8 trials.

Trial Pipeline

221 total, page 4 of 5

COMPLETED Phase 1

EYE001 to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome

NCT00056199

COMPLETED Phase 1

Laser and Antioxidant Treatment of Diabetic Macular Edema

NCT00055042

COMPLETED

Biological Markers in Retinal Vasculitis

NCT00050492

COMPLETED Phase 3

Laser and Medical Treatment of Diabetic Macular Edema

NCT00050479

COMPLETED

Dynamic Light Scattering and Keratoscopy for Corneal Examination

NCT00050466

COMPLETED Phase 1

Saccadic Eye Movements in Patients With Niemann-Pick Type C Disease

NCT00316498

COMPLETED Phase 2

Celecoxib to Treat Macular Degeneration in Patients Receiving Photodynamic Therapy

NCT00043680

COMPLETED Phase 2

Daclizumab Injections to Treat Non-Infectious Sight-Threatening Uveitis

NCT00043667

COMPLETED

Prevalence and Risk of Cataracts in Granulocyte Donors

NCT00042627

COMPLETED

Differences in Genes and Proteins in Active and Controlled Uveitis

NCT00357266

COMPLETED Phase 1

Laser and Medical Treatment of Diabetic Macular Edema

NCT00027287

COMPLETED Phase 1

Vitamin E to Treat Uveitis-Associated Macular Edema

NCT00021645

COMPLETED Phase 1

Identification and Treatment of Feeder Vessels in Macular Degeneration

NCT00018070

COMPLETED

A Novel Acuity Testing Method

NCT00013936

COMPLETED

Evaluation and Treatment of Patients With Inherited Eye Diseases

NCT00011817

COMPLETED

Evaluation and Treatment of Patients With Corneal and External Diseases

NCT00008541

COMPLETED Phase 1

Fluocinolone Implant to Treat Macular Degeneration

NCT00008515

COMPLETED

Dynamic Light Scattering Device (DLS) Study of Age-Related Changes in the Lens and Cataracts

NCT00007215

COMPLETED NA

Evaluation and Treatment of Pediatric Eye Diseases

NCT00006422

COMPLETED Phase 2

Lutein for Age-Related Macular Degeneration

NCT00006202

COMPLETED

Evaluation and Treatment of Patients With Inflammatory Eye Diseases

NCT00006188

COMPLETED

Cause of Pigment Dispersion Syndrome

NCT00005919

COMPLETED

Magnetic Resonance Imaging to Study the Normal Eye

NCT00005911

COMPLETED

Evaluation and Treatment of Patients With Retinal Disease

NCT00005784

COMPLETED

Blood Factors and Diabetic Retinopathy

NCT00005761

COMPLETED

Genetic Study of Age-Related Macular Degeneration

NCT00357578

COMPLETED NA

Cornea Donor Study

NCT00006411

COMPLETED

Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye

NCT00001143

COMPLETED

Effect of Pregnancy on Uveitis

NCT00001867

COMPLETED Phase 2

Eye Muscle Surgery to Treat Congenital Nystagmus

NCT00001866

COMPLETED Phase 2

HAT in Eye Complications of Behcet's Disease

NCT00001865

COMPLETED Phase 3

Amblyopia (Lazy Eye) Treatment Study

NCT00001864

COMPLETED Phase 3

Complications of Age-Related Macular Degeneration Prevention Trial

NCT00000167

COMPLETED Phase 2

Leflunomide to Treat Uveitis

NCT00001863

COMPLETED Phase 2

TNRF:Fc to Treat Eye Inflammation in Juvenile Rheumatoid Arthritis

NCT00001862

COMPLETED

Screening for Studies on Nystagmus and Strabismus

NCT00001861

COMPLETED

Vascular Endothelial Growth Factor (VEGF) in Uveitis

NCT00001738

COMPLETED Phase 1

New Cysteamine Eye Drops Formulation to Treat Corneal Crystals in Cystinosis

NCT00001736

COMPLETED Phase 1

Cyclosporin Implant to Treat Uveitis

NCT00001737

COMPLETED Phase 1

Gene Therapy for Gyrate Atrophy

NCT00001735

COMPLETED

Screening for NEI Clinical Studies

NCT00001734

COMPLETED

Screening for Studies on Retinovascular Diseases

NCT00001733

COMPLETED

Screening for Studies on Inherited Eye Diseases

NCT00001732

COMPLETED Phase 2

Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops

NCT00001731

COMPLETED

Test of QLS Device to Detect Early Cataracts

NCT00001617

COMPLETED Phase 1

Phase I Study of Corticosteroid Treatment of Ill-Defined Choroidal Neovascularization in Age-Related Macular Degeneration

NCT00001615

COMPLETED Phase 1

The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis

NCT00001614

COMPLETED

Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts

NCT00001613

COMPLETED

Long-Term Follow-Up of Patients Enrolled in the Early Treatment Diabetic Retinopathy Study (ETDRS)

NCT00001612

COMPLETED

Immune Activity Against CVM Retinitis

NCT00001611

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What the Pipeline for National Eye Institute (NEI) Shows

According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 221 US clinical trials across every stage of research activity. Of those, 18 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 179 are already marked complete, representing roughly 81% of the total.

The phase mix for National Eye Institute (NEI) reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 86 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-related Macular Degeneration with 8 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.