National Eye Institute (NEI)
National Eye Institute (NEI) sponsors 221 registered US clinical trials on ClinicalTrials.gov, 18 of them currently recruiting, and 179 completed. 11 of these trials are in Phase 3-4 (later-stage) and 86 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Age-related Macular Degeneration, with 8 trials.
Trial Pipeline
221 total, page 4 of 5
EYE001 to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome
NCT00056199
Laser and Antioxidant Treatment of Diabetic Macular Edema
NCT00055042
Biological Markers in Retinal Vasculitis
NCT00050492
Laser and Medical Treatment of Diabetic Macular Edema
NCT00050479
Dynamic Light Scattering and Keratoscopy for Corneal Examination
NCT00050466
Saccadic Eye Movements in Patients With Niemann-Pick Type C Disease
NCT00316498
Celecoxib to Treat Macular Degeneration in Patients Receiving Photodynamic Therapy
NCT00043680
Daclizumab Injections to Treat Non-Infectious Sight-Threatening Uveitis
NCT00043667
Prevalence and Risk of Cataracts in Granulocyte Donors
NCT00042627
Differences in Genes and Proteins in Active and Controlled Uveitis
NCT00357266
Laser and Medical Treatment of Diabetic Macular Edema
NCT00027287
Vitamin E to Treat Uveitis-Associated Macular Edema
NCT00021645
Identification and Treatment of Feeder Vessels in Macular Degeneration
NCT00018070
A Novel Acuity Testing Method
NCT00013936
Evaluation and Treatment of Patients With Inherited Eye Diseases
NCT00011817
Evaluation and Treatment of Patients With Corneal and External Diseases
NCT00008541
Fluocinolone Implant to Treat Macular Degeneration
NCT00008515
Dynamic Light Scattering Device (DLS) Study of Age-Related Changes in the Lens and Cataracts
NCT00007215
Evaluation and Treatment of Pediatric Eye Diseases
NCT00006422
Lutein for Age-Related Macular Degeneration
NCT00006202
Evaluation and Treatment of Patients With Inflammatory Eye Diseases
NCT00006188
Cause of Pigment Dispersion Syndrome
NCT00005919
Magnetic Resonance Imaging to Study the Normal Eye
NCT00005911
Evaluation and Treatment of Patients With Retinal Disease
NCT00005784
Blood Factors and Diabetic Retinopathy
NCT00005761
Genetic Study of Age-Related Macular Degeneration
NCT00357578
Cornea Donor Study
NCT00006411
Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye
NCT00001143
Effect of Pregnancy on Uveitis
NCT00001867
Eye Muscle Surgery to Treat Congenital Nystagmus
NCT00001866
HAT in Eye Complications of Behcet's Disease
NCT00001865
Amblyopia (Lazy Eye) Treatment Study
NCT00001864
Complications of Age-Related Macular Degeneration Prevention Trial
NCT00000167
Leflunomide to Treat Uveitis
NCT00001863
TNRF:Fc to Treat Eye Inflammation in Juvenile Rheumatoid Arthritis
NCT00001862
Screening for Studies on Nystagmus and Strabismus
NCT00001861
Vascular Endothelial Growth Factor (VEGF) in Uveitis
NCT00001738
New Cysteamine Eye Drops Formulation to Treat Corneal Crystals in Cystinosis
NCT00001736
Cyclosporin Implant to Treat Uveitis
NCT00001737
Gene Therapy for Gyrate Atrophy
NCT00001735
Screening for NEI Clinical Studies
NCT00001734
Screening for Studies on Retinovascular Diseases
NCT00001733
Screening for Studies on Inherited Eye Diseases
NCT00001732
Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops
NCT00001731
Test of QLS Device to Detect Early Cataracts
NCT00001617
Phase I Study of Corticosteroid Treatment of Ill-Defined Choroidal Neovascularization in Age-Related Macular Degeneration
NCT00001615
The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis
NCT00001614
Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts
NCT00001613
Long-Term Follow-Up of Patients Enrolled in the Early Treatment Diabetic Retinopathy Study (ETDRS)
NCT00001612
Immune Activity Against CVM Retinitis
NCT00001611
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 62 |
| Phase 2 | 24 |
| Phase 3 | 11 |
Therapeutic Areas
What the Pipeline for National Eye Institute (NEI) Shows
According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 221 US clinical trials across every stage of research activity. Of those, 18 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 179 are already marked complete, representing roughly 81% of the total.
The phase mix for National Eye Institute (NEI) reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 86 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-related Macular Degeneration with 8 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.