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Cataract clinical trials
20 of 85 indexed Cataract trials are currently recruiting.
85 US clinical trials · 20 currently recruiting
Cataract is the subject of 85 registered US clinical trials on ClinicalTrials.gov, 20 of them currently open to new participants. 30 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Alcon Research, running 12 of these trials.
The research picture
Cataract has 85 registered US clinical trials, 20 of them open to new participants right now, about 24% of the total.
- 20
- recruiting participants now
- 24%
- of trials open to enrollment
- 30
- in Phase 3–4 (later-stage)
- 12
- top sponsor: Alcon Research
Active & Recent Trials
85 total, page 1 of 2
Intraocular Lens Power Calculation After Laser Refractive Surgery Based on Optical Coherence Tomography
Oregon Health and Science University
NCT00532051
A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)
Melt Pharmaceuticals
NCT06383273
IC-8 Apthera IOL New Enrollment Post Approval Study
Bausch & Lomb Incorporated
NCT06060041
Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)
SpyGlass Pharma
NCT07218783
Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)
SpyGlass Pharma
NCT07218796
A Prospective, Randomized, Subject and Vision-assessor Masked, Multicenter Study Comparing Bilateral Clareon PanOptix, Bilateral Clareon PanOptix Pro, and Mixed Clareon PanOptix Pro/Vivity Intraocular Lens Implantation in Cataract Subjects
Berkeley Eye Center
NCT06922084
Intraoperative OCT Guidance of Intraocular Surgery II
Duke University
NCT03713268
To Study Ocular Outflow Dynamics of the Eye Using Intraoperative Tonographic Biometry and Assess Its Predictive Value in Improving Postoperative Outcomes.
The New York Eye & Ear Infirmary
NCT07425496
Unity VCS: A Comparison Study Evaluating Corneal Clarity and Thickness
Metrolina Eye Associates, P
NCT07222150
Study of Complication Rates in Cataract Surgery Patients Treated With Combined Pre-operative NSAID, OMIDRIA, and Subconjunctival Triamcinolone Acetonide Compared With Peri-operative SOC
Inder Paul Singh, M.D.
NCT06681688
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
University of California, San Francisco
NCT05157113
Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract
EyePoint Pharmaceuticals
NCT05191706
Effective Phaco Time and Endothelial Cell Loss When Using Veritas
Aloha Vision Consultants
NCT07176416
Refractive Outcomes Utilizing Two SS-OCT Biometers for IOL Power Calculations
The Eye institute of Utah
NCT06801678
Evaluation of a Monofocal Intraocular Lens
Carl Zeiss Meditec
NCT06428955
Outcomes of Clareon PanOptix Pro in Patients With Prior Myopic Refractive Surgery
Juliette Eye Institute Research Center
NCT06555289
Evaluation of Head-Mounted Spatial Computing and Three-Dimensional (3D) Visualization in Ocular Microsurgery: A Safety and Workflow Study
Sharp HealthCare
NCT07301385
Odyssey Evaluation in Post LASIK Patients
Center For Sight
NCT07260695
Results of Patients With Glaucoma Undergoing Minimally Invasive Glaucoma Surgery in Conjunction With Cataract Surgery
Vold Vision P.L.L.C
NCT05624398
Ketorolac Levels in Vitreous and Aqueous Samples From Patients Undergoing Combined Cataract and Pars Plana Vitrectomy Surgeries With and Without Intracameral Phenylephrine 1.0% / Ketorolac 0.3%
DHS Consulting
NCT06539637
Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)
Columbia University
NCT04271709
Study to Evaluate the Safety and Effectiveness of the enVista® Beyond (EY) EDF Intraocular Lens in Subjects Undergoing Cataract Extraction
Bausch & Lomb Incorporated
NCT06333015
Evaluation of the Bimatoprost Implant System Used in Combination With the SpyGlass Intraocular Lens Compared to Timolol Ophthalmic Solution
SpyGlass Pharma
NCT06120842
Age-Related Eye Disease Study (AREDS) Follow-Up
National Eye Institute (NEI)
NCT00594672
Impact of a Novel Extended Depth of Focus Intraocular Lens on Visual and Lifestyle Enhancement
Alanna Nattis, DO
NCT04570579
Quatera 700 vs. Centurion
Carolina Eyecare Physicians
NCT06225362
Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study
University of California, San Francisco
NCT06506669
Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts
National Eye Institute (NEI)
NCT00056771
A Study of Interventions to Reduce Disability From Visual Loss in Nursing Home Residents
Johns Hopkins University
NCT00348621
The Effects of Music and Television on Intraoperative Hypertensive Events in Cataract Surgery
Montefiore Medical Center
NCT06356324
Clinical Evaluation of a Small Aperture Extended Depth of Focus Intraocular Lens
AcuFocus
NCT03633695
I-ZIP Ocular Bandage Pivotal Study
Ocular Therapeutix
NCT00774228
Clinical Investigation of the Clareon® Intraocular Lens (IOL)
Alcon Research
NCT03170154
Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
Bausch & Lomb Incorporated
NCT01591161
Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation
Xigen
NCT02235272
A Study of MELT-300 (Midazolam and Ketamine Sublingual Tablets) for Sedation and Intraoperative Ocular Analgesia in Participants Undergoing Cataract Extraction With Lens Replacement (CELR)
Melt Pharmaceuticals
NCT05133518
Mapracorat Ophthalmic Suspension for the Treatment of Ocular Inflammation Following Cataract Surgery
Bausch & Lomb Incorporated
NCT01230125
Clinical Investigation of the Safety and Effectiveness of an Investigational Model of the TECNIS® Intraocular Lens
Johnson & Johnson Surgical Vision
NCT03949335
Safety and Efficacy of a Violet Visible Light Blocking Intraocular Lens (IOL)
Abbott Medical Optics
NCT00747227
Clinical Investigation of AcrySof® IQ PanOptix™ IOL Model TFNT00
Alcon Research
NCT03280108
A Clinical Study of the ACRYSOF® IQ Extended Depth of Focus Intraocular Lens (IOL)
Alcon Research
NCT03274986
Clinical Investigation of the Next-Generation Intraocular Lenses
Abbott Medical Optics
NCT03372434
Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-2)
Salvat
NCT04249076
Clareon Toric vs Eyhance Toric
Alcon Research
NCT05481125
To Compare the Ability of DiscoVisc® OVD to Protect the Corneal Endothelium and Maintain Anterior Chamber Space With Healon® and Amvisc® PLUS During Cataract Surgery.
Alcon Research
NCT00763360
The Heidelberg Engineering ANTERION Anterior Segment Cornea and IOL Precision and Agreement Study
Heidelberg Engineering
NCT04130490
Study of T-PRED(TM) Compared to Pred Forte(R) II
Bausch & Lomb Incorporated
NCT00854061
Surgeon Experience ReSTOR A +4 Intraocular Lens (IOL)
Alcon Research
NCT00733512
Comparison of the Hoya Surgical Optics (HSO) iSert 251 Posterior Chamber Aspheric Aphakic Intraocular Lens to Historical / Literature Controls.
Hoya Surgical Optics
NCT01292629
Posterior Capsule Opacification (PCO) Evaluation of the AcrySof SN60AT Lens vs. SN60WF Lens
Alcon Research
NCT00762021
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 1 |
| Phase 3 | 10 |
| Phase 4 | 20 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cataract Trial Landscape
85 indexed Cataract studies · 20 recruiting (24%).
Phase mix: 30 late (III/IV) vs 5 early (I/II).
Top sponsor: Alcon Research (12 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cataract?
PlainTrial tracks 85 US clinical trials for Cataract, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cataract?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.