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Cataract clinical trials
Every US clinical trial registered for Cataract — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
85 US clinical trials · 20 currently recruiting
The research picture
Cataract has 85 registered US clinical trials, 20 of them open to new participants right now — about 24% of the total.
- 20
- recruiting participants now
- 24%
- of trials open to enrollment
- 30
- in Phase 3–4 (later-stage)
- 12
- top sponsor: Alcon Research
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Intraocular Lens Power Calculation After Laser Refractive Surgery Based on Optical Coherence Tomography
Oregon Health and Science University
NCT00532051
A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)
Melt Pharmaceuticals
NCT06383273
IC-8 Apthera IOL New Enrollment Post Approval Study
Bausch & Lomb Incorporated
NCT06060041
Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)
SpyGlass Pharma
NCT07218783
Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)
SpyGlass Pharma
NCT07218796
A Prospective, Randomized, Subject and Vision-assessor Masked, Multicenter Study Comparing Bilateral Clareon PanOptix, Bilateral Clareon PanOptix Pro, and Mixed Clareon PanOptix Pro/Vivity Intraocular Lens Implantation in Cataract Subjects
Berkeley Eye Center
NCT06922084
Intraoperative OCT Guidance of Intraocular Surgery II
Duke University
NCT03713268
To Study Ocular Outflow Dynamics of the Eye Using Intraoperative Tonographic Biometry and Assess Its Predictive Value in Improving Postoperative Outcomes.
The New York Eye & Ear Infirmary
NCT07425496
Unity VCS: A Comparison Study Evaluating Corneal Clarity and Thickness
Metrolina Eye Associates, P
NCT07222150
Study of Complication Rates in Cataract Surgery Patients Treated With Combined Pre-operative NSAID, OMIDRIA, and Subconjunctival Triamcinolone Acetonide Compared With Peri-operative SOC
Inder Paul Singh, M.D.
NCT06681688
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
University of California, San Francis
NCT05157113
Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract
EyePoint Pharmaceuticals
NCT05191706
Effective Phaco Time and Endothelial Cell Loss When Using Veritas
Aloha Vision Consultants
NCT07176416
Refractive Outcomes Utilizing Two SS-OCT Biometers for IOL Power Calculations
The Eye institute of Utah
NCT06801678
Evaluation of a Monofocal Intraocular Lens
Carl Zeiss Meditec
NCT06428955
Outcomes of Clareon PanOptix Pro in Patients With Prior Myopic Refractive Surgery
Juliette Eye Institute Research Center
NCT06555289
Evaluation of Head-Mounted Spatial Computing and Three-Dimensional (3D) Visualization in Ocular Microsurgery: A Safety and Workflow Study
Sharp HealthCare
NCT07301385
Odyssey Evaluation in Post LASIK Patients
Center For Sight
NCT07260695
Results of Patients With Glaucoma Undergoing Minimally Invasive Glaucoma Surgery in Conjunction With Cataract Surgery
Vold Vision P.L.L.C
NCT05624398
Ketorolac Levels in Vitreous and Aqueous Samples From Patients Undergoing Combined Cataract and Pars Plana Vitrectomy Surgeries With and Without Intracameral Phenylephrine 1.0% / Ketorolac 0.3%
DHS Consulting
NCT06539637
Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)
Columbia University
NCT04271709
Study to Evaluate the Safety and Effectiveness of the enVista® Beyond (EY) EDF Intraocular Lens in Subjects Undergoing Cataract Extraction
Bausch & Lomb Incorporated
NCT06333015
Evaluation of the Bimatoprost Implant System Used in Combination With the SpyGlass Intraocular Lens Compared to Timolol Ophthalmic Solution
SpyGlass Pharma
NCT06120842
Age-Related Eye Disease Study (AREDS) Follow-Up
National Eye Institute (NEI)
NCT00594672
Impact of a Novel Extended Depth of Focus Intraocular Lens on Visual and Lifestyle Enhancement
Alanna Nattis, DO
NCT04570579
Quatera 700 vs. Centurion
Carolina Eyecare Physicians
NCT06225362
Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study
University of California, San Francis
NCT06506669
Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts
National Eye Institute (NEI)
NCT00056771
A Study of Interventions to Reduce Disability From Visual Loss in Nursing Home Residents
Johns Hopkins University
NCT00348621
The Effects of Music and Television on Intraoperative Hypertensive Events in Cataract Surgery
Montefiore Medical Center
NCT06356324
Clinical Evaluation of a Small Aperture Extended Depth of Focus Intraocular Lens
AcuFocus
NCT03633695
I-ZIP Ocular Bandage Pivotal Study
Ocular Therapeutix
NCT00774228
Clinical Investigation of the Clareon® Intraocular Lens (IOL)
Alcon Research
NCT03170154
Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
Bausch & Lomb Incorporated
NCT01591161
Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation
Xigen
NCT02235272
A Study of MELT-300 (Midazolam and Ketamine Sublingual Tablets) for Sedation and Intraoperative Ocular Analgesia in Participants Undergoing Cataract Extraction With Lens Replacement (CELR)
Melt Pharmaceuticals
NCT05133518
Mapracorat Ophthalmic Suspension for the Treatment of Ocular Inflammation Following Cataract Surgery
Bausch & Lomb Incorporated
NCT01230125
Clinical Investigation of the Safety and Effectiveness of an Investigational Model of the TECNIS® Intraocular Lens
Johnson & Johnson Surgical Vision
NCT03949335
Safety and Efficacy of a Violet Visible Light Blocking Intraocular Lens (IOL)
Abbott Medical Optics
NCT00747227
Clinical Investigation of AcrySof® IQ PanOptix™ IOL Model TFNT00
Alcon Research
NCT03280108
A Clinical Study of the ACRYSOF® IQ Extended Depth of Focus Intraocular Lens (IOL)
Alcon Research
NCT03274986
Clinical Investigation of the Next-Generation Intraocular Lenses
Abbott Medical Optics
NCT03372434
Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-2)
Salvat
NCT04249076
Clareon Toric vs Eyhance Toric
Alcon Research
NCT05481125
To Compare the Ability of DiscoVisc® OVD to Protect the Corneal Endothelium and Maintain Anterior Chamber Space With Healon® and Amvisc® PLUS During Cataract Surgery.
Alcon Research
NCT00763360
The Heidelberg Engineering ANTERION Anterior Segment Cornea and IOL Precision and Agreement Study
Heidelberg Engineering
NCT04130490
Study of T-PRED(TM) Compared to Pred Forte(R) II
Bausch & Lomb Incorporated
NCT00854061
Surgeon Experience ReSTOR A +4 Intraocular Lens (IOL)
Alcon Research
NCT00733512
Comparison of the Hoya Surgical Optics (HSO) iSert 251 Posterior Chamber Aspheric Aphakic Intraocular Lens to Historical / Literature Controls.
Hoya Surgical Optics
NCT01292629
Posterior Capsule Opacification (PCO) Evaluation of the AcrySof SN60AT Lens vs. SN60WF Lens
Alcon Research
NCT00762021
Effect of Intraocular Lens (IOL) Centration and Tilt on Visual Performance With Clareon® Vivity® IOL Implantation
East Coast Institute for Research
NCT05827133
Assessment of Low Energy Lens Fragmentation Cataract Extraction in Patients Undergoing Cataract Surgery
Carl Zeiss Meditec
NCT04747834
Ocular Tissue Levels of 1.5% Levofloxacin Ophthalmic Solution Compared to an Active Comparator
Santen
NCT00630019
Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts
National Eye Institute (NEI)
NCT00001613
Femtosecond Laser Assisted Keratotomies for the Management of Corneal Astigmatism
Milton S. Hershey Medical Center
NCT04676451
Evaluation of the EpiGlare Tester for the Measurement of Glare-Induced Changes in BSCVA in Subjects With and Without Cataracts
Epico
NCT04739397
Conventional Surgery vs. Verion/VerifEye
Carolina Eyecare Physicians
NCT02513745
Efficacy of Dextenza Insert in Upper vs Lower Punctum Following Cataract Surgery With PCIOL.
Iworks Laser and Vision Center
NCT05372315
Monofocal IOL Visual Outcomes When Targeting Mini Monovision
Carolina Eyecare Physicians
NCT05069415
Rotational Stability of the AcrySof® Toric
Alcon Research
NCT00762216
A Comparison of Corneal Aberrations in Subjects With Contralateral AcrySof IQ Toric Intraocular Lens (IOL) and AcrySof IQ IOL With Limbal Relaxing Incision (LRI)
Alcon Research
NCT01045733
A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs)
Alcon Research
NCT01166971
A Study Assessing the Safety and Efficacy of Dextenza® for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract
Ocular Therapeutix
NCT04539548
Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery
Alcon Research
NCT00870103
Symfony vs Vivity in Dim Light
Carolina Eyecare Physicians
NCT06229106
Dropless vs. Standard Drops Contralateral Eye Study
Carolina Eyecare Physicians
NCT02515045
Post-market Study to Obtain Surgeon Feedback on Clinical Outcome in Eyes Implanted With TECNIS Toric II IOL
Johnson & Johnson Surgical Vision
NCT04210232
Clinical Comparison of Length of Cataract Procedures With Zeiss Lumera Versus Older Zeiss Microscope
Toyos Clinic
NCT03298841
Bioavailability of Bimatoprost Ophthalmic Solution in Human Aqueous.
Indiana University School of Medicine
NCT00355446
Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs
Indiana University School of Medicine
NCT00392275
Intraocular Steroid After Cataract Surgery Study
Dean Health System
NCT00478764
Evaluation of Effective Lens Position With a Uniplanar Bi-aspheric IOL
Lenstec Incorporated
NCT01248572
Investigate, Following Cataract Surgery With IOL in Conjunction With Intracanalicular Dexamethasone Insert
Wolstan and Goldberg Eye Associates
NCT04465864
Veracity Surgical: A Time/Motion and Quality of Care Study
Research Insight
NCT04337892
Clinical Outcomes With Bilateral Implantation of Odyssey IOLs
Mann Eye Institute
NCT06550375
Prophylactic Treatment: Lessdrops™ vs Standard Drops Regimen
Carolina Eyecare Physicians
NCT03578276
Visual Function and Patient Satisfaction After Bilateral Implantation of AcrySof Natural ReSTOR (Model SN60D3) or AcrySof Natural Monofocal (Model SN60AT)
Alcon Research
NCT00759668
Evaluation of Quality of Vision and Visual Outcomes With Bilateral Implantation of the Clareon PanOptix Intraocular Lens
Newsom Eye & Laser Center
NCT05518539
The Evaluation of Balanced Salt Solution During Cataract Surgery
Adam Fedyk, MD, FACS
NCT05853978
Binocular Custom Vision Utilizing The Light Adjustable Lens (LAL)
Vance Thompson Vision
NCT04533191
Evaluation of the Aspheric ReSTOR IOL After Routine Cataract Extraction
Medical University of South Carolina
NCT00720005
Refractive and Visual Outcomes With the ARGOS Biometer In Eyes With a History of Refractive Surgery: ARGOS Study
Vance Thompson Vision
NCT07129980
Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty
Massachusetts Eye and Ear Infirmary
NCT04057053
Test of QLS Device to Detect Early Cataracts
National Eye Institute (NEI)
NCT00001617
Ketorolac vs. Steroid in the Prevention of CME
Innovative Medical
NCT00348244
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 1 |
| Phase 3 | 10 |
| Phase 4 | 20 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cataract Trial Landscape
ClinicalTrials.gov lists 85 US studies indexed under Cataract, and 20 of those are currently open to recruitment — roughly 24% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Cataract shows 30 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Cataract is led by Alcon Research with 12 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 85 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cataract?
PlainTrial tracks 85 US clinical trials for Cataract, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cataract?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.