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2026 data Public-data reference. official source

Retinitis Pigmentosa

Open-data reference.

38 US clinical trials · 15 currently recruiting

Active & Recent Trials

RECRUITING 1,500 participants

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

Jaeb Center for Health Research

NCT05589714

RECRUITING 930 participants

Cell Collection to Study Eye Diseases

National Eye Institute (NEI)

NCT01432847

RECRUITING 600 participants

High Resolution Retinal Imaging

University of Pennsylvania

NCT01866371

RECRUITING NA 500 participants

Stem Cell Ophthalmology Treatment Study II

MD Stem Cells

NCT03011541

RECRUITING 500 participants

Rod and Cone Mediated Function in Retinal Disease

National Eye Institute (NEI)

NCT02617966

RECRUITING 400 participants

Retinal Imaging in Patients With Inherited Retinal Degenerations

University of California, San Francis

NCT00254605

RECRUITING 120 participants

Observational Study to Assess Endpoint Operational Feasibility & Measurement Properties in Patients with Retinal Degeneration

Ray Therapeutics

NCT06375239

RECRUITING 100 participants

Adaptive Optics Imaging of Outer Retinal Diseases

Food and Drug Administration (FDA)

NCT05355415

RECRUITING Phase 2 60 participants

Safety of a Single, Intravitreal Injection of 6.0M jCell (Famzeretcel) in Retinitis Pigmentosa (RP)

jCyte

NCT06912633

RECRUITING 52 participants

Study of BEST1 Vitelliform Macular Dystrophy

Columbia University

NCT05809635

RECRUITING Phase 1 33 participants

Promising ROd-cone DYstrophy Gene therapY

SparingVision

NCT05748873

RECRUITING Phase 1 20 participants

BS01 in Patients With Retinitis Pigmentosa

Bionic Sight

NCT04278131

RECRUITING NA 20 participants

Experimental and Clinical Studies of Retinal Stimulation

University of Michigan

NCT03635645

RECRUITING Phase 1 15 participants

The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

University of Rochester

NCT06319872

RECRUITING Phase 1 12 participants

A Study to Investigate the Safety of DSP-3077 After a Unilateral Eye Injection in Male and Female Participants 18 Years of Age or Older With Retinitis Pigmentosa

Sumitomo Pharma America

NCT06891885

ACTIVE NOT RECRUITING Phase 3 485 participants

Oral N-acetylcysteine for Retinitis Pigmentosa

Johns Hopkins University

NCT05537220

ACTIVE NOT RECRUITING Phase 3 140 participants

A Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa

Ocugen

NCT06388200

ACTIVE NOT RECRUITING 103 participants

Rate of Progression in EYS Related Retinal Degeneration

Jaeb Center for Health Research

NCT04127006

ACTIVE NOT RECRUITING NA 82 participants

Prospective Natural History Study of Retinitis Pigmentosa

SparingVision

NCT04285398

ACTIVE NOT RECRUITING 50 participants

Natural History of PRPF31 Mutation-Associated Retinal Dystrophy

PYC Therapeutics

NCT05573984

ACTIVE NOT RECRUITING 44 participants

Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F

Jaeb Center for Health Research

NCT04765345

ACTIVE NOT RECRUITING Phase 1 30 participants

FIGHT-RP 1 Extension Study

Johns Hopkins University

NCT03999021

ACTIVE NOT RECRUITING Phase 1 22 participants

Study to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis

Ocugen

NCT05203939

ACTIVE NOT RECRUITING NA 21 participants

Electro-acupuncture and Transcorneal Electrical Stimulation (TES) for Retinitis Pigmentosa

Nova Southeastern University

NCT02086890

ACTIVE NOT RECRUITING 18 participants

Non-Interventional Long Term Follow-up Study of Participants Previously Enrolled in the RESTORE Study

Nanoscope Therapeutics

NCT06162585

ACTIVE NOT RECRUITING Phase 1 16 participants

CNS10-NPC for the Treatment of RP

Cedars-Sinai Medical Center

NCT04284293

ACTIVE NOT RECRUITING Phase 1 15 participants

Clinical Trial of Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy

University of California, Davis

NCT01736059

ACTIVE NOT RECRUITING 12 participants

A Prospective, Observational Study in Adults With Retinitis Pigmentosa (RP)

Sumitomo Pharma America

NCT06517940

ACTIVE NOT RECRUITING Phase 1 10 participants

Study to Evaluate Safety of RTx-015 Injection in Retinitis Pigmentosa or Choroideremia Patients (ENVISION)

Ray Therapeutics

NCT06460844

COMPLETED 3,549 participants

Molecular Genetics of Retinal Degenerations

National Eye Institute (NEI)

NCT00231010

COMPLETED Phase 2 90 participants

Trial of Oral Valproic Acid for Retinitis Pigmentosa

Foundation Fighting Blindness

NCT01233609

COMPLETED 35 participants

Observational Study to Assess the Reliability and Validity of the MLYMT and MLSDT

Nanoscope Therapeutics

NCT05820100

COMPLETED Phase 2 30 participants

Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects With Retinitis Pigmentosa

jCyte

NCT04604899

COMPLETED Phase 2 27 participants

Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE]

Nanoscope Therapeutics

NCT04945772

COMPLETED Phase 1 11 participants

Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa

National Eye Institute (NEI)

NCT00065455

COMPLETED NA 9 participants

Object Finder for a Retinal Prosthesis

Minnesota HealthSolutions

NCT04319809

COMPLETED NA 4 participants

Argus II/ORCAM Device Study

Mayo Clinic

NCT03248388

COMPLETED NA 4 participants

Computer-Assisted Rehabilitation Environment Training After Argus Retinal Prosthesis

The Cleveland Clinic

NCT03444961

Phase Distribution

PhaseTrial count
Early Phase 1 10
Phase 2 4
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Retinitis Pigmentosa Trial Landscape

ClinicalTrials.gov lists 38 US studies indexed under Retinitis Pigmentosa, and 15 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Retinitis Pigmentosa shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 14 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Retinitis Pigmentosa is led by National Eye Institute (NEI) with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 38 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Retinitis Pigmentosa?

PlainTrial tracks 38 US clinical trials for Retinitis Pigmentosa, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Retinitis Pigmentosa?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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