National Eye Institute (NEI)
National Eye Institute (NEI) sponsors 221 registered US clinical trials on ClinicalTrials.gov, 18 of them currently recruiting, and 179 completed. 11 of these trials are in Phase 3-4 (later-stage) and 86 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Age-related Macular Degeneration, with 8 trials.
Trial Pipeline
221 total, page 2 of 5
Gevokizumab for Active Scleritis
NCT01835132
AMD Phenotype and Genotype Study
NCT01778491
CNTF Implants for CNGB3 Achromatopsia
NCT01648452
Ranibizumab and Bevacizumab for Diabetic Macular Edema
NCT01610557
Finasteride for Chronic Central Serous Chorioretinopathy
NCT01585441
Minocycline to Treat Branch Retinal Vein Occlusion
NCT01468831
Blood and Saliva Sample Collection for AREDS 2
NCT01553474
Intravitreal Injections of Sirolimus in the Treatment of Geographic Atrophy
NCT01675947
Sirolimus Injections for Autoimmune Scleritis
NCT01517074
Minocycline to Treat Central Retinal Vein Occlusion
NCT01468844
Topical Interferon Gamma-1b for Central Serous Chorioretinopathy
NCT01468337
Sirolimus for Advanced Age-Related Macular Degeneration
NCT01445548
Dextromethorphan for Diabetic Macular Edema
NCT01441102
Topical Interferon Gamma for Macular Edema Secondary to Uveitis
NCT01376362
The Natural History of Graft-Versus-Host Disease in the Eyes
NCT01369914
Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate
NCT01314417
Palomid 529 in Patients With Neovascular Age-Related Macular Degeneration
NCT01271270
Extension Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy
NCT01227993
Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis
NCT01195948
Evaluation of Single Nucleotide Polymorphisms (SNPs) in Patients With and Without Diabetic Macular Edema
NCT01168258
Immunogenetic Mechanisms in Behcet's Disease
NCT01109433
A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema
NCT01120899
Rituximab for Autoimmune Retinopathy
NCT01086631
Internal Monitoring of Eye Movement in Schizophrenia
NCT01011101
The Treatment of Uveitic Cystoid Macular Edema With Topical Interferon Gamma
NCT00943982
Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti
NCT00876434
Pilot Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy
NCT00837252
Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral GA Associated With AMD
NCT00766649
Sirolimus to Treat Diabetic Macular Edema
NCT00711490
Evaluation and Treatment of People With Eye Diseases
NCT00708955
Ranibizumab Injections to Treat Macular Telangiectasia Without New Blood Vessel Growth
NCT00685854
Ranibizumab Injections to Treat Macular Telangiectasia With New Blood Vessel Growth
NCT00685503
Validation of Computerized Vision-Targeted Quality-of-Life Questionnaires
NCT00678860
Sunitinib Malate to Treat Advanced Eye Disease in Patients With Von Hippel-Lindau Syndrome
NCT00673816
High Speed Indocyanine Green Angiography Findings in Ranibizumab Treatment for Wet Age-related Macular Degeneration
NCT00656903
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
NCT00647439
Detection of Neutralizing Antibodies in Patients Treated With Bevacizumab or Ranibizumab
NCT00605943
Visual Motor Coordination
NCT00568243
Potential Research Participants for Future Studies of Inherited Eye Diseases
NCT00559234
Human Samples and Data Repository
NCT00539370
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
NCT00471731
Injected Ranibizumab to Treat Macular Telangiectasia With New Blood Vessel Formation
NCT00457067
Injected Ranibizumab to Treat Macular Telangiectasia Without New Blood Vessel Formation
NCT00457145
The Vitreous Proteome and Inflammatory Mediators in Ocular Inflammatory Disease
NCT00331331
TAC-PF, Avastin® in Combination With Photodynamic Therapy to Treat Age Related Macular Degeneration
NCT00464347
Longitudinal Evaluation of Silicone Hydrogel (LASH) Study
NCT00727402
Metabolic Mapping to Measure Retinal Metabolism
NCT00385333
Repository for Inherited Eye Diseases
NCT00378742
Eye and Immunogenetic Features of Sarcoidosis
NCT00379275
Age-Related Eye Disease Study 2 (AREDS2)
NCT00345176
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 62 |
| Phase 2 | 24 |
| Phase 3 | 11 |
Therapeutic Areas
What the Pipeline for National Eye Institute (NEI) Shows
According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 221 US clinical trials across every stage of research activity. Of those, 18 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 179 are already marked complete, representing roughly 81% of the total.
The phase mix for National Eye Institute (NEI) reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 86 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-related Macular Degeneration with 8 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.