National Eye Institute (NEI)

221 total trials 18 currently recruiting 179 completed

National Eye Institute (NEI) sponsors 221 registered US clinical trials on ClinicalTrials.gov, 18 of them currently recruiting, and 179 completed. 11 of these trials are in Phase 3-4 (later-stage) and 86 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Age-related Macular Degeneration, with 8 trials.

Trial Pipeline

221 total, page 2 of 5

COMPLETED Phase 1

Gevokizumab for Active Scleritis

NCT01835132

COMPLETED

AMD Phenotype and Genotype Study

NCT01778491

COMPLETED Phase 1

CNTF Implants for CNGB3 Achromatopsia

NCT01648452

COMPLETED Phase 2

Ranibizumab and Bevacizumab for Diabetic Macular Edema

NCT01610557

TERMINATED Phase 2

Finasteride for Chronic Central Serous Chorioretinopathy

NCT01585441

COMPLETED Phase 1

Minocycline to Treat Branch Retinal Vein Occlusion

NCT01468831

COMPLETED

Blood and Saliva Sample Collection for AREDS 2

NCT01553474

TERMINATED Phase 2

Intravitreal Injections of Sirolimus in the Treatment of Geographic Atrophy

NCT01675947

COMPLETED Phase 1

Sirolimus Injections for Autoimmune Scleritis

NCT01517074

COMPLETED Phase 1

Minocycline to Treat Central Retinal Vein Occlusion

NCT01468844

COMPLETED Phase 1

Topical Interferon Gamma-1b for Central Serous Chorioretinopathy

NCT01468337

COMPLETED Phase 1

Sirolimus for Advanced Age-Related Macular Degeneration

NCT01445548

COMPLETED Phase 1

Dextromethorphan for Diabetic Macular Edema

NCT01441102

COMPLETED Phase 1

Topical Interferon Gamma for Macular Edema Secondary to Uveitis

NCT01376362

COMPLETED

The Natural History of Graft-Versus-Host Disease in the Eyes

NCT01369914

TERMINATED Phase 1

Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate

NCT01314417

COMPLETED Phase 1

Palomid 529 in Patients With Neovascular Age-Related Macular Degeneration

NCT01271270

COMPLETED Phase 1

Extension Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy

NCT01227993

COMPLETED Phase 1

Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis

NCT01195948

TERMINATED

Evaluation of Single Nucleotide Polymorphisms (SNPs) in Patients With and Without Diabetic Macular Edema

NCT01168258

TERMINATED

Immunogenetic Mechanisms in Behcet's Disease

NCT01109433

COMPLETED Phase 1

A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema

NCT01120899

COMPLETED Phase 1

Rituximab for Autoimmune Retinopathy

NCT01086631

TERMINATED

Internal Monitoring of Eye Movement in Schizophrenia

NCT01011101

COMPLETED Phase 1

The Treatment of Uveitic Cystoid Macular Edema With Topical Interferon Gamma

NCT00943982

COMPLETED Phase 1

Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti

NCT00876434

COMPLETED Phase 1

Pilot Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy

NCT00837252

COMPLETED Phase 1

Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral GA Associated With AMD

NCT00766649

COMPLETED Phase 1

Sirolimus to Treat Diabetic Macular Edema

NCT00711490

COMPLETED

Evaluation and Treatment of People With Eye Diseases

NCT00708955

COMPLETED Phase 1

Ranibizumab Injections to Treat Macular Telangiectasia Without New Blood Vessel Growth

NCT00685854

COMPLETED Phase 1

Ranibizumab Injections to Treat Macular Telangiectasia With New Blood Vessel Growth

NCT00685503

COMPLETED

Validation of Computerized Vision-Targeted Quality-of-Life Questionnaires

NCT00678860

TERMINATED Phase 1

Sunitinib Malate to Treat Advanced Eye Disease in Patients With Von Hippel-Lindau Syndrome

NCT00673816

COMPLETED

High Speed Indocyanine Green Angiography Findings in Ranibizumab Treatment for Wet Age-related Macular Degeneration

NCT00656903

COMPLETED

Genetics and Markers of Degenerative and Inflammatory Eye Diseases

NCT00647439

COMPLETED

Detection of Neutralizing Antibodies in Patients Treated With Bevacizumab or Ranibizumab

NCT00605943

TERMINATED

Visual Motor Coordination

NCT00568243

COMPLETED

Potential Research Participants for Future Studies of Inherited Eye Diseases

NCT00559234

TERMINATED

Human Samples and Data Repository

NCT00539370

COMPLETED

Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

NCT00471731

COMPLETED Phase 1

Injected Ranibizumab to Treat Macular Telangiectasia With New Blood Vessel Formation

NCT00457067

COMPLETED Phase 1

Injected Ranibizumab to Treat Macular Telangiectasia Without New Blood Vessel Formation

NCT00457145

COMPLETED

The Vitreous Proteome and Inflammatory Mediators in Ocular Inflammatory Disease

NCT00331331

TERMINATED Phase 2

TAC-PF, Avastin® in Combination With Photodynamic Therapy to Treat Age Related Macular Degeneration

NCT00464347

COMPLETED

Longitudinal Evaluation of Silicone Hydrogel (LASH) Study

NCT00727402

COMPLETED Phase 2

Metabolic Mapping to Measure Retinal Metabolism

NCT00385333

COMPLETED

Repository for Inherited Eye Diseases

NCT00378742

COMPLETED

Eye and Immunogenetic Features of Sarcoidosis

NCT00379275

COMPLETED Phase 3

Age-Related Eye Disease Study 2 (AREDS2)

NCT00345176

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What the Pipeline for National Eye Institute (NEI) Shows

According to the ClinicalTrials.gov registry, National Eye Institute (NEI) is linked to 221 US clinical trials across every stage of research activity. Of those, 18 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 179 are already marked complete, representing roughly 81% of the total.

The phase mix for National Eye Institute (NEI) reports 11 late-stage studies (Phase 3 and Phase 4 combined) and 86 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Eye Institute (NEI) is Age-related Macular Degeneration with 8 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.