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NCT00265590 · ClinicalTrials.gov registry record
Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia
A clinical trial of Aniridia, sponsored by National Eye Institute (NEI).
- Completed
- Registry status
- 100
- Enrollment target
- 3
- Study locations
NCT00265590 is a study of Aniridia that has completed, run by National Eye Institute (NEI). The registered enrollment target is 100 participants. The trial reports 3 study locations across 3 states.
The verdict
NCT00265590, a study of Aniridia, has completed, sponsored by National Eye Institute (NEI).
- COMPLETED
- Registry status
- 100 participants
- Enrollment target
- 3
- Study locations
Study Summary
This study will examine specific gene changes in patients with aniridia, a disease in which the iris (colored part of the eye) is absent or partially absent, and will correlate the changes with clinical manifestations of the disease. In aniridia, the eye often appears to have no color, but only a larger than normal pupil. Patients may have impaired vision and cataracts, glaucoma, nystagmus (rapid, involuntary eye movements), photophobia (light sensitivity), displaced lens, underdeveloped retina, and thickened cornea. This study will focus particularly on corneal changes. Patients 4 years old and older with aniridia may be eligible for this study. Candidates are screened with a family history and complete eye examination, including the following: * Visual acuity testing using a vision chart. * Eye pressure measurement. * Fundus photography to examine the back of the eye: The pupils are dilated and special photographs of the inside of the eye are taken to evaluate the retina and measure changes that may occur over time. The camera flashes a bright light into the eye for each picture. * Slit lamp examination: Evaluation of the front part of the eye with a special microscope called a slit lamp biomicroscope. * Corneal thickness measurement. Participants have blood drawn for genetic testing related to aniridia. Relevant medical information, including disease severity and complications, is obtained over time. Family members may also be requested to provide blood samples for genetic testing.
Conditions Studied
Study Locations (3)
Illinois
- University of Chicago - Chicago
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Ohio
- University of Cincinnati - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2005-12-07 |
| Est. Completion | 2008-10-03 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00265590
The ClinicalTrials.gov registry entry for NCT00265590 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Eye Institute (NEI), which has 221 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Aniridia appearing as the primary indexed condition, and to 0 interventions.
NCT00265590 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Illinois, Maryland, Ohio.
Frequently Asked Questions
What is clinical trial NCT00265590 about?
NCT00265590 is a clinical study titled "Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia". This study will examine specific gene changes in patients with aniridia, a disease in which the iris (colored part of the eye) is absent or partially absent, and will correlate the changes with clinical manifestations of the disease. In aniridia, the eye often appears to have no color, but only a la...
What is the current status of trial NCT00265590?
This trial is currently completed. The enrollment target is 100 participants. The study started on 2005-12-07. Estimated completion is 2008-10-03.
What conditions does trial NCT00265590 study?
This clinical trial studies the following conditions: Aniridia.
Who is sponsoring clinical trial NCT00265590?
This trial is sponsored by National Eye Institute (NEI), which has 221 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00265590 being conducted?
This trial has 3 study locations across Illinois, Maryland, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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