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NCT00718653 · ClinicalTrials.gov registry record · NA
Effects of Antioxidants on Human Macular Pigments
A NA study, sponsored by National Eye Institute (NEI).
- Completed
- Registry status
- NA
- Development phase
- 40
- Enrollment target
NCT00718653: Completed NA study, sponsored by National Eye Institute (NEI).
NCT00718653 is a NA study that has completed, run by National Eye Institute (NEI). The registered enrollment target is 40 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00718653, a NA study, has completed, sponsored by National Eye Institute (NEI).
- COMPLETED
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
Study Summary
Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. Low dietary intake or low blood levels of lutein and zeaxanthin, which are the only pigments found in the macular region of the human retina, has been associated with an increased risk for AMD. We have reported that the dietary supplementation of lutein and zeaxanthin can increase the macular pigments (MP) of the eye. MP effectively absorbs blue light as well as quenches reactive oxygen species (ROS). Green tea polyphenols are also effective scavenger of ROS in vitro. Our goal is to elucidate how to effectively increase MP by physiologic levels of antioxidant supplementation. We hypothesize that lutein and tea polyphenols protect the macula of the eye by increasing MP carotenoids effectively through an antioxidant mechanism.
Interventions
- DIETARY_SUPPLEMENT Lutein
- DIETARY_SUPPLEMENT Lutein plus green tea extract
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2004-09 |
| Est. Completion | 2007-12 |
| Phase | NA |
What the finished NCT00718653 record still lists
NCT00718653 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Lutein is the first listed.
NCT00718653 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00718653 about?
NCT00718653 is a clinical study titled "Effects of Antioxidants on Human Macular Pigments". Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. Low dietary intake or low blood levels of lutein and zeaxanthin, which are the only pigments found in the macular region of the human retina, has been associated with an increased risk for AMD. We have rep...
What is the current status of trial NCT00718653?
This trial is currently completed. It is a NA study. The enrollment target is 40 participants. The study started on 2004-09. Estimated completion is 2007-12.
What interventions are being tested in trial NCT00718653?
The interventions under investigation include: Lutein (DIETARY_SUPPLEMENT), Lutein plus green tea extract (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT00718653?
This trial is sponsored by National Eye Institute (NEI), which has 221 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00718653's enrollment target sits among peer trials
40 1447th of 2000 higher than 465 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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