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NCT00718653 · ClinicalTrials.gov registry record · NA
Effects of Antioxidants on Human Macular Pigments
A NA study, sponsored by National Eye Institute (NEI).
- Completed
- Registry status
- NA
- Development phase
- 40
- Enrollment target
NCT00718653 is a NA study that has completed, run by National Eye Institute (NEI). The registered enrollment target is 40 participants.
The verdict
NCT00718653, a NA study, has completed, sponsored by National Eye Institute (NEI).
- COMPLETED
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
Study Summary
Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. Low dietary intake or low blood levels of lutein and zeaxanthin, which are the only pigments found in the macular region of the human retina, has been associated with an increased risk for AMD. We have reported that the dietary supplementation of lutein and zeaxanthin can increase the macular pigments (MP) of the eye. MP effectively absorbs blue light as well as quenches reactive oxygen species (ROS). Green tea polyphenols are also effective scavenger of ROS in vitro. Our goal is to elucidate how to effectively increase MP by physiologic levels of antioxidant supplementation. We hypothesize that lutein and tea polyphenols protect the macula of the eye by increasing MP carotenoids effectively through an antioxidant mechanism.
Interventions
- DIETARY_SUPPLEMENT Lutein
- DIETARY_SUPPLEMENT Lutein plus green tea extract
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2004-09 |
| Est. Completion | 2007-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00718653
The ClinicalTrials.gov registry entry for NCT00718653 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Eye Institute (NEI), which has 221 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Lutein is the first listed.
NCT00718653 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00718653 about?
NCT00718653 is a clinical study titled "Effects of Antioxidants on Human Macular Pigments". Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. Low dietary intake or low blood levels of lutein and zeaxanthin, which are the only pigments found in the macular region of the human retina, has been associated with an increased risk for AMD. We have rep...
What is the current status of trial NCT00718653?
This trial is currently completed. It is a NA study. The enrollment target is 40 participants. The study started on 2004-09. Estimated completion is 2007-12.
What interventions are being tested in trial NCT00718653?
The interventions under investigation include: Lutein (DIETARY_SUPPLEMENT), Lutein plus green tea extract (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT00718653?
This trial is sponsored by National Eye Institute (NEI), which has 221 total clinical trials registered on ClinicalTrials.gov.
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