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ClinicalTrials.gov 8 recruiting now official registry

Retinal Degeneration clinical trials

8 of 18 indexed Retinal Degeneration trials are currently recruiting.

18 US clinical trials · 8 currently recruiting

Retinal Degeneration is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is National Eye Institute (NEI), running 5 of these trials.

The research picture

Retinal Degeneration has 18 registered US clinical trials, 8 of them open to new participants right now, about 44% of the total.

8
recruiting participants now
44%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
5
top sponsor: National Eye Institute (NEI)
Phase 15Phase 22Phase 31

Active & Recent Trials

18 total, page 1 of 1

RECRUITING 930 participants

Cell Collection to Study Eye Diseases

National Eye Institute (NEI)

NCT01432847

RECRUITING 500 participants

Rod and Cone Mediated Function in Retinal Disease

National Eye Institute (NEI)

NCT02617966

RECRUITING 100 participants

Adaptive Optics Imaging of Outer Retinal Diseases

Food and Drug Administration (FDA)

NCT05355415

RECRUITING Phase 2 70 participants

SGLT2 Inhibitors in Geographic Atrophy

Washington University School of Medicine

NCT07174687

RECRUITING Phase 1 56 participants

Oral Metformin for Treatment of ABCA4 Retinopathy

National Eye Institute (NEI)

NCT04545736

RECRUITING Phase 1 54 participants

A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)

BlueRock Therapeutics

NCT06789445

RECRUITING Phase 1 16 participants

A Repeat-Dose, Open-Label, Two Arm Safety and Efficacy Study of Two Doses of VP-001 Administered Intravitreally in Participants With Confirmed PRPF31 Mutation-Associated Retinal Dystrophy, Including Participants Previously Treated With VP001

PYC Therapeutics

NCT06852963

RECRUITING Phase 1 12 participants

MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby)

PYC Therapeutics

NCT06455826

ACTIVE NOT RECRUITING 250 participants

Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study

Complement Therapeutics

NCT05797896

ACTIVE NOT RECRUITING 68 participants

Natural History of Eye Diseases Related to ABCA4 Mutations

National Eye Institute (NEI)

NCT01736293

ACTIVE NOT RECRUITING 44 participants

Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F

Jaeb Center for Health Research

NCT04765345

ACTIVE NOT RECRUITING 18 participants

Non-Interventional Long Term Follow-up Study of Participants Previously Enrolled in the RESTORE Study

Nanoscope Therapeutics

NCT06162585

COMPLETED 3,549 participants

Molecular Genetics of Retinal Degenerations

National Eye Institute (NEI)

NCT00231010

COMPLETED NA 36 participants

A Multi-Center Study of Reading Rehabilitation in Macular Disease

US Department of Veterans Affairs

NCT00746668

COMPLETED Phase 2 27 participants

Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE]

Nanoscope Therapeutics

NCT04945772

COMPLETED 26 participants

Natural History Study of CEP290-Related Retinal Degeneration

Editas Medicine

NCT03396042

COMPLETED Phase 1 24 participants

Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy

Pfizer

NCT01003691

COMPLETED Phase 3 14 participants

Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD

Novartis Pharmaceuticals

NCT03954626

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 2
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Retinal Degeneration Trial Landscape

18 indexed Retinal Degeneration studies · 8 recruiting (44%).

Phase mix: 1 late (III/IV) vs 7 early (I/II).

Top sponsor: National Eye Institute (NEI) (5 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Retinal Degeneration?

PlainTrial tracks 18 US clinical trials for Retinal Degeneration, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Retinal Degeneration?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.