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NCT01577706 · ClinicalTrials.gov registry record · NA
Spectroscopic Imaging at 4T: A Drug Challenge Study
A NA study, sponsored by Mclean Hospital.
- Terminated
- Registry status
- NA
- Development phase
- 7
- Enrollment target
NCT01577706: Clinical Trial NA study, sponsored by Mclean Hospital.
NCT01577706 is a NA study that was terminated before completion, run by Mclean Hospital. The registered enrollment target is 7 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01577706, a NA study, was terminated before completion, sponsored by Mclean Hospital.
- TERMINATED
- Registry status
- NA
- Development phase
- 7 participants
- Enrollment target
Study Summary
An advanced technique for rapid magnetic resonance proton spectroscopic imaging (1H-MRSI) will be employed in a drug challenge study in healthy volunteers to spatially map and measure acute changes in the brain chemicals GABA, glutamate and glutamine after administration of a drug. Three condition will be tested in a double-blind fashion, i)depressant, ii)stimulant, iii)placebo. It is hypothesized that unique and reproducible spatial and directional metabolic response patterns will be observed, unique to each condition within the brain.
Primary Outcome
The primary goal of this study is to assess the efficacy of an advanced spectroscopic imaging protocol in detecting changes in the levels of brain GABA in response to an acute drug challenge. GABA levels are expressed as a ratio to total creatinine: GABA/Cr percent change = 100\*(later timepoint - earlier timepoint) / earlier timepoint
Interventions
- OTHER Placebo
- DRUG Alprazolam
- DRUG Dextroamphetamine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2013-06 |
| Est. Completion | 2013-12 |
| Phase | NA |
Why NCT01577706 stopped before completion
NCT01577706 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT01577706 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01577706 about?
NCT01577706 is a clinical study titled "Spectroscopic Imaging at 4T: A Drug Challenge Study". An advanced technique for rapid magnetic resonance proton spectroscopic imaging (1H-MRSI) will be employed in a drug challenge study in healthy volunteers to spatially map and measure acute changes in the brain chemicals GABA, glutamate and glutamine after administration of a drug. Three condition w...
What is the current status of trial NCT01577706?
This trial is currently terminated. It is a NA study. The enrollment target is 7 participants. The study started on 2013-06. Estimated completion is 2013-12.
What interventions are being tested in trial NCT01577706?
The interventions under investigation include: Placebo (OTHER), Alprazolam (DRUG), Dextroamphetamine (DRUG).
Who is sponsoring clinical trial NCT01577706?
This trial is sponsored by Mclean Hospital, which has 140 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01577706's enrollment target sits among peer trials
7 1982nd of 2000 higher than 18 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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