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NCT03998748 · ClinicalTrials.gov registry record · NA
Electrophysiological Correlates of Cognition in Depression
A NA study, sponsored by Mclean Hospital.
- Terminated
- Registry status
- NA
- Development phase
- 80
- Enrollment target
NCT03998748: Clinical Trial NA study, sponsored by Mclean Hospital.
NCT03998748 is a NA study that was terminated before completion, run by Mclean Hospital. The registered enrollment target is 80 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03998748, a NA study, was terminated before completion, sponsored by Mclean Hospital.
- TERMINATED
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
Study Summary
Biogenetic messages about the etiology of mental illness (e.g., the "chemical imbalance theory" of depression) are increasing but the impact that these have on decision-making and motivation is not yet clear. This study will evaluate the impact of biogenetic feedback on cognitive control and default-mode network functioning, as well as motivation for different psychiatric treatment modalities. Participants with major depressive disorder (MDD) will be instructed that they are being tested for genetic susceptibility to depression and will be randomized to receive feedback that they either do or do not have a genetic predisposition to depression. Before and after receiving this feedback, brain activity will be assessed using high-density electroencephalogram (EEG). The investigators hypothesize that those exposed to the genetic feedback condition will evidence heightened ruminative default mode network activity and perceive medications to be more effective than psychotherapy.
Primary Outcome
Resting-state EEG
Interventions
- OTHER Sham Genetic Feedback
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2019-10-08 |
| Est. Completion | 2022-08-01 |
| Phase | NA |
Why NCT03998748 stopped before completion
NCT03998748 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 1 intervention - of which Sham Genetic Feedback is the first listed.
NCT03998748 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03998748 about?
NCT03998748 is a clinical study titled "Electrophysiological Correlates of Cognition in Depression". Biogenetic messages about the etiology of mental illness (e.g., the "chemical imbalance theory" of depression) are increasing but the impact that these have on decision-making and motivation is not yet clear. This study will evaluate the impact of biogenetic feedback on cognitive control and default...
What is the current status of trial NCT03998748?
This trial is currently terminated. It is a NA study. The enrollment target is 80 participants. The study started on 2019-10-08. Estimated completion is 2022-08-01.
What interventions are being tested in trial NCT03998748?
The interventions under investigation include: Sham Genetic Feedback (OTHER).
Who is sponsoring clinical trial NCT03998748?
This trial is sponsored by Mclean Hospital, which has 140 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03998748's enrollment target sits among peer trials
80 994th of 2000 higher than 941 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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