Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Smoking: early-phase trial registry
27 of 124 indexed Smoking trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #96 of 28,707 conditions by registered trial count.
124 US clinical trials · 27 currently recruiting · #96 of 28,707 conditions by registered trial count
Smoking: 124 US clinical trials tracked, 27 recruiting.
Smoking is the subject of 124 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 9 of these trials.
Enrollment posture brief
Registry condition smoking
OPEN 27 | RECR 22% | LATE 13 | EARLY 22 | RANK #96 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Plaque Psoriasis (22% recruiting · 46 trials)
Smoking lists 27 open slots (22% of 124 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Smoking on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Smoking is recruiting below its size-band peers.
27 of 124 indexed trials (21.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Smoking trials is spread across many organizations.
RAI Services Company accounts for 9 of 124 trials (7.3%). 62 distinct sponsors appear on at least one study for this condition label.
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Typical Smoking enrolment sits around 165 participants.
Median target enrolment is 165 among the 124 trials that report a genuine target (sentinel values excluded). 48 of those (38.7%) plan for fewer than 100 participants.
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Smoking research is mostly interventional.
113 interventional and 11 observational studies make up this index (91.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
124 total, page 1 of 3
The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study
Memorial Sloan Kettering Cancer Center
NCT06535867
App for Reducing Cravings to Smoke
H. Lee Moffitt Cancer Center and Research Institute
NCT06088498
Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network
Children's Hospital of Philadelphia
NCT06582693
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Weill Medical College of Cornell University
NCT01776398
Personalized Tobacco Treatment in Primary Care (MOTIVATE)
Washington University School of Medicine
NCT05846841
Take A Break - Rural
Wake Forest University Health Sciences
NCT05790486
Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia
University of Virginia
NCT05660525
Integrating Financial Coaching and Smoking Cessation Coaching
NYU Langone Health
NCT05154669
Technology Assisted Motivational Interviewing
University of California, San Francisco
NCT06713603
Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos
University of Rochester
NCT06926608
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Ohio State University
NCT06055036
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
Philip Morris Products S.A.
NCT07108166
Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children
University of Minnesota
NCT04783857
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
Yale University
NCT06077240
A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse
Eli Lilly and Company
NCT07223840
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
Abramson Cancer Center at Penn Medicine
NCT06264154
Clinical Alternatives for Reducing Harm Using E-cigarettes
Medical University of South Carolina
NCT07039292
Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior
Penn State University
NCT05572671
Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients
Washington University School of Medicine
NCT07166120
Enhancing Motivation to Quit Smoking Via Self-Help Intervention Targeted to Cancer Type
University of Utah
NCT06484179
Bayesian Neurobehavioral Phenotyping: From Mechanism Identification to Personalized Neuromodulation Treatments. R61 PHASE
M.D. Anderson Cancer Center
NCT06991062
Inspire HER: Inspiring the Heart and Emotions for Radical Health
University of Alabama at Birmingham
NCT06966258
Ethnic Microaggressions and Smoking Behaviors Among Latinx Adults
University of Houston
NCT05490927
The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence
University of Florida
NCT05814055
Effects of a Specific Substance in Smokers
Oregon Health and Science University
NCT04281979
Abuse Liability for Five Modern Oral Nicotine Products
RAI Services Company
NCT07132814
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
Memorial Sloan Kettering Cancer Center
NCT06693700
Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks
University of Colorado, Denver
NCT05641974
Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health
American College of Radiology
NCT06055972
A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities
University of Minnesota
NCT05671380
Literacy and Smoking Risk Communications
M.D. Anderson Cancer Center
NCT00684437
Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)
M.D. Anderson Cancer Center
NCT04200534
Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV
Seattle Institute for Biomedical and Clinical Research
NCT04505371
Digitally Enhanced Smoking Cessation for High Risk Smokers
Dana-Farber Cancer Institute
NCT04691297
Smoking Cessation for Depressed Smokers
M.D. Anderson Cancer Center
NCT00494728
The Effect of Tobacco Products on Wound Healing
University of Minnesota
NCT04870970
Smartphone-delivered Scheduled Smoking With Compliance Facilitation as an Adjunct Cessation Therapy: a Feasibility Study
M.D. Anderson Cancer Center
NCT05763771
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal
University of Alabama at Birmingham
NCT03968900
A Study to Develop a Strategy to Increase Lung Cancer Screening in Women Who May Be at Risk for Lung Cancer
Memorial Sloan Kettering Cancer Center
NCT04848961
Enhancing Mental and Physical Health of Women Veterans
VA Office of Research and Development
NCT05050266
Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava
University of Florida
NCT05081882
Quitlink : A Leveraging Solution to Tobacco Counseling
Virginia Ambulatory Care Outcomes Research Network
NCT00112268
Tobacco Cessation Via Public Health Dental Clinics
Oregon Research Institute
NCT00683839
Helping Poor Smokers Quit
Washington University School of Medicine
NCT03194958
Proactive Outreach for Smokers in VA Mental Health
VA Office of Research and Development
NCT01737281
'Questions About Quitting' Smoking Cessation Trial
Kaiser Permanente
NCT00992264
Evaluating a Telephone-Based Smoking Cessation Program Among People in the Military (The AFIII Study)
University of Tennessee
NCT00632411
A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco
Medical University of South Carolina
NCT01509586
A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers
University of Wisconsin, Madison
NCT01553084
Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines
University of Wisconsin, Madison
NCT01087905
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 13 |
| Phase 3 | 4 |
| Phase 4 | 9 |
Top Sponsors
Named interventions
Most-linked intervention names on Smoking records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Smoking trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Smoking page
124 registered trials, 27 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 27 Smoking trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- RAI Services Company sponsors the most Smoking trials on record, review their full trial history before evaluating a specific study. See RAI Services Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Smoking condition card totals 124 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.