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Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
NCT06937086 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of this study is to show whether in these individuals, treatment with both mirikizumab and tirzepatide, compared with treatment with mirikizumab and placebo, leads to decrease or disappearance of UC symptoms, and loss of at least one-tenth of the overall body weight. Participation in this study will last up to 61 weeks, including 52 weeks of treatment.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Tirzepatide
- DRUG Mirikizumab
Study Locations (20)
Florida
- Research Associates of South Florida - Miami - Southwest 8th Street — Miami
- Gastro Health Research - Miami — Miami
- Orlando Health — Orlando
- Digestive and Liver Center of Florida — Orlando
- Gastro Health Research - Pensacola — Pensacola
- Precision Clinical Research — Sunrise
California
- Smart Cures Clinical Research — Anaheim
- Cedars-Sinai Medical Center — Beverly Hills
- United Medical Doctors - Los Alamitos — Los Alamitos
- California Medical Research Associates — Northridge
Indiana
- Indiana University Health University Hospital — Indianapolis
- Gastroenterology Health Partners — New Albany
Louisiana
- Care Access - New Iberia — New Iberia
- Louisiana Research Center — Shreveport
Alabama
- Digestive Health Specialists — Dothan
Idaho
- Grand Teton Research Group — Idaho Falls
Illinois
- Rush University Medical Center — Chicago
Kentucky
- Gastroenterology Health Partners — Louisville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 350 participants |
| Start Date | 2025-06-26 |
| Est. Completion | 2028-04 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06937086
The ClinicalTrials.gov registry entry for NCT06937086 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 350 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Ulcerative Colitis appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06937086 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, California, Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06937086 about?
NCT06937086 is a clinical study titled "Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study". The main purpose of this study is to show whether in these individuals, treatment with both mirikizumab and tirzepatide, compared with treatment with mirikizumab and placebo, leads to decrease or disappearance of UC symptoms, and loss of at least one-tenth of the overall body weight. Participation ...
What is the current status of trial NCT06937086?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 350 participants. The study started on 2025-06-26. Estimated completion is 2028-04.
What conditions does trial NCT06937086 study?
This clinical trial studies the following conditions: Ulcerative Colitis, Obesity or Overweight. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06937086?
The interventions under investigation include: Placebo (DRUG), Tirzepatide (DRUG), Mirikizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06937086?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06937086 being conducted?
This trial has 20 study locations across Alabama, California, Florida, Idaho, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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