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LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
NCT07186101 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of the study is to evaluate the effectiveness and safety of LY4268989 when given with mirikizumab compared to mirikizumab alone in adult participants with moderately to severely active ulcerative colitis (UC). Study participation will last approximately 118 weeks, including 104 weeks of treatment and may include up to 21 visits.
Conditions Studied
Interventions
- DRUG Mirikizumab
- DRUG LY4268989
- DRUG LY4268989 Placebo
Study Locations (20)
Florida
- NeoClinical Research — Hialeah
- Encore Borland-Groover Clinical Research — Jacksonville
- Clinical Research of Osceola — Kissimmee
- Florida Research Institute — Lakewood Rch
- Alliance Medical Research — Lighthouse PT
- Atlantic Medical Research — Margate
- Digestive and Liver Center of Florida — Orlando
Illinois
- Center for Gastrointestinal Health - Fairview Heights — Belleville
- Midtown Gastroenterology and Liver Disease — Des Plaines
- GI Alliance - Glenview — Glenview
- Gi Alliance - Gurnee — Gurnee
California
- Clinnova Research - Anaheim — Anaheim
- Om Research LLC — Lancaster
- Biopharma Informatic, LLC — Los Angeles
Arizona
- Mayo Clinic in Arizona - Scottsdale — Scottsdale
Colorado
- Peak Gastroenterology Associates — Colorado Springs
Indiana
- Gastroenterology Health Partners — New Albany
Kentucky
- Gastroenterology Health Partners — Louisville
Massachusetts
- Brigham and Women's Hospital — Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 252 participants |
| Start Date | 2025-11-11 |
| Est. Completion | 2029-03 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07186101
The ClinicalTrials.gov registry entry for NCT07186101 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 252 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Ulcerative Colitis appearing as the primary indexed condition, and to 3 interventions — of which Mirikizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07186101 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Florida, Illinois, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07186101 about?
NCT07186101 is a clinical study titled "LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:". The main purpose of the study is to evaluate the effectiveness and safety of LY4268989 when given with mirikizumab compared to mirikizumab alone in adult participants with moderately to severely active ulcerative colitis (UC). Study participation will last approximately 118 weeks, including 104 wee...
What is the current status of trial NCT07186101?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 252 participants. The study started on 2025-11-11. Estimated completion is 2029-03.
What conditions does trial NCT07186101 study?
This clinical trial studies the following conditions: Ulcerative Colitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07186101?
The interventions under investigation include: Mirikizumab (DRUG), LY4268989 (DRUG), LY4268989 Placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07186101?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07186101 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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