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NCT05987852 · ClinicalTrials.gov registry record · NA

Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

A NA study of Ulcerative Colitis, sponsored by Northwestern University.

Recruiting
Registry status
NA
Development phase
126
Enrollment target
13
Study locations

NCT05987852 is a NA study of Ulcerative Colitis that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 126 participants, below the 2,056-participant average among 122 other Ulcerative Colitis trials with a reported enrollment target (94% lower). The trial reports 13 study locations across 10 states.

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The verdict

NCT05987852, a NA study of Ulcerative Colitis, is actively recruiting participants, sponsored by Northwestern University.

RECRUITING
Registry status
NA
Development phase
126 participants
Enrollment target
13
Study locations

Study Summary

Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation. Two small prospective randomized controlled trials have demonstrated that the delivery of HBOT to UC patients hospitalized for acute moderate to severe flares results in improved remission rates and avoidance of in-hospital progression to biologics, small molecules, or colectomy. In this larger trial the study aims to confirm the treatment benefits of HBOT for hospitalized UC patients and study the immune-microbe mechanisms underpinning treatment response.

Conditions Studied

Ulcerative Colitis

Interventions

  • DEVICE Hyperbaric Oxygen Therapy
  • OTHER Sham Hyperbaric Air

Study Locations (13)

Florida

  • University of Miami Health - Miami
  • Orlando Health - Orlando

New York

  • Cornell University Medical Center - New York
  • State University of New York Upstate Medical University - Syracuse

Pennsylvania

  • Allegheny Health - Pittsburgh
  • University of Pittsburgh Medical Center - Pittsburgh

Alabama

  • University of Alabama Medicine - Birmingham

California

  • University of Los Angeles Health - Los Angeles

Illinois

  • Northwestern Medicine Lake Forest Hospital - Lake Forest

Kentucky

  • University of Louisville - Louisville

Massachusetts

  • Massachusetts General Hospital - Boston

Trial Details

FieldValue
Enrollment Target 126 participants
Start Date 2024-01-09
Est. Completion 2027-09-01
Phase NA

Sponsor

Northwestern University

1,209 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05987852

The ClinicalTrials.gov registry entry for NCT05987852 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 126 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,056-participant average among 122 other Ulcerative Colitis trials with a reported enrollment target (94% lower). The listed sponsor is Northwestern University, which has 1,209 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Ulcerative Colitis appearing as the primary indexed condition, and to 2 interventions - of which Hyperbaric Oxygen Therapy is the first listed.

NCT05987852 reports 13 study locations spanning 10 distinct geographic areas - top geographies include Florida, New York, Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT05987852 about?

NCT05987852 is a clinical study titled "Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)". Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation. Two small prospective randomized controlled trials have demo...

What is the current status of trial NCT05987852?

This trial is currently recruiting. It is a NA study. The enrollment target is 126 participants. The study started on 2024-01-09. Estimated completion is 2027-09-01.

What conditions does trial NCT05987852 study?

This clinical trial studies the following conditions: Ulcerative Colitis.

What interventions are being tested in trial NCT05987852?

The interventions under investigation include: Hyperbaric Oxygen Therapy (DEVICE), Sham Hyperbaric Air (OTHER).

Who is sponsoring clinical trial NCT05987852?

This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05987852 being conducted?

This trial has 13 study locations across Alabama, California, Florida, Illinois, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.