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Ulcerative Colitis clinical trials
45 of 123 indexed Ulcerative Colitis trials are currently recruiting.
123 US clinical trials · 45 currently recruiting
Ulcerative Colitis is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 47 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 9 of these trials.
The research picture
Ulcerative Colitis has 123 registered US clinical trials, 45 of them open to new participants right now, about 37% of the total.
- 45
- recruiting participants now
- 37%
- of trials open to enrollment
- 32
- in Phase 3–4 (later-stage)
- 9
- top sponsor: Eli Lilly and Company
Active & Recent Trials
123 total, page 2 of 3
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
Janssen Research & Development
NCT04033445
A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
Eli Lilly and Company
NCT03519945
A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)
Merck Sharp & Dohme
NCT06052059
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
Pfizer
NCT03950232
An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis
Janssen Biotech
NCT02808780
Volatile Organic Compounds (VOCs) in Active Inflammatory Bowel Disease
The Cleveland Clinic
NCT04827368
Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis
Gilead Sciences
NCT06290934
A Study of Mirikizumab (LY3074828) in Participants With Moderately to Severely Active Ulcerative Colitis
Eli Lilly and Company
NCT05767021
A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis
AbbVie
NCT06257875
A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)
AnaptysBio
NCT06127043
Proactive Infliximab Optimization Using a Pharmacokinetic Dashboard Versus Standard of Care in Patients With Inflammatory Bowel Disease: The OPTIMIZE Trial
Beth Israel Deaconess Medical Center
NCT04835506
A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy
University of Maryland, Baltimore
NCT05316584
Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.
AbbVie
NCT05782907
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
Pfizer
NCT04624230
Efficacy/Safety of ALTB-268 in Subjects w/Moderately to Severely Active UC Refractory to Biologics
AltruBio
NCT06109441
A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis
Boehringer Ingelheim
NCT06636656
Testing Atorvastatin to Lower Colon Cancer Risk in Longstanding Ulcerative Colitis
Northwestern University
NCT04767984
Aquamin® as an Adjuvant Intervention for Ulcerative Colitis
Muhammad N Aslam, MD
NCT03869905
Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis
Rush University Medical Center
NCT05213234
CP101 for the Treatment of Ulcerative Colitis
Brigham and Women's Hospital
NCT05852574
Angiographic Delivery of AD-MSC for Ulcerative Colitis
Mayo Clinic
NCT04312113
Pharmacokinetics of IFX and TNF Concentrations in Serum, Stool, and Colonic Mucosa in Acute Severe Ulcerative Colitis
Alimentiv
NCT03765450
Phase 2a to Evaluate PL-8177 in Subjects with Active Ulcerative Colitis (UC)
Palatin Technologies
NCT05466890
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
University Hospitals Cleveland Medical Center
NCT00622557
A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis
Eli Lilly and Company
NCT03524092
A Comparison of Once a Day Dose Compared to 2 Doses/Day
Warner Chilcott
NCT00505778
Study to Determine Risk Factors for Post-operative Infection in Inflammatory Bowel Disease
Icahn School of Medicine at Mount Sinai
NCT02054533
A Study To Evaluate Both The Efficacy and Safety Profile of CP-690,550 In Patients With Moderately to Severely Active Ulcerative Colitis
Pfizer
NCT01458951
Randomized Placebo-Controlled Trial of Budesonide Multi-Matrix System (MMX®) 9 Milligrams (mg) in Participants With Ulcerative Colitis Currently on a 5-Aminosalicylic Acid (5-ASA)
Bausch Health Americas
NCT01532648
Comparative Effectiveness of Biologics or Small Molecule Therapies in Inflammatory Bowel Disease (IBD)
University of North Carolina, Chapel Hill
NCT04852666
Open-Label, Long-term Balsalziade Disodium Tablet Ulcerative Colitis Study
Bausch Health Americas
NCT00486031
Long-Term Safety and Tolerability of Mesalamine Pellets in Participants With Ulcerative Colitis in Remission
Bausch Health Americas
NCT00326209
A Study Of PF-00547659 In Patients With Moderate To Severe Ulcerative Colitis
Shire
NCT01620255
Telemedicine in Patients With Inflammatory Bowel Disease (TELE-IBD)
University of Maryland, Baltimore
NCT01692743
Trial on Impact of HealthPROMISE Mobile App on Inflammatory Bowel Disease Care and Quality of Life
Icahn School of Medicine at Mount Sinai
NCT02322307
Study to Compare Oral PF-06651600, PF-06700841 and Placebo in Subjects With Moderate to Severe Ulcerative Colitis
Pfizer
NCT02958865
Mesalamine 2 g Sachet for the Maintenance of Clinical and Endoscopic Remission in Ulcerative Colitis (UC)
Ferring Pharmaceuticals
NCT02522780
Safety and Efficacy of OP2000 (Deligoparin) in the Treatment of Active Ulcerative Colitis
Incara Pharmaceuticals
NCT00033943
Efficacy and Safety Study of Ozanimod in Ulcerative Colitis
Celgene
NCT01647516
Improving Medication Adherence in Pediatric Inflammatory Bowel Disease
Children's Hospital Medical Center, Cincinnati
NCT01536509
(CB-01-02/04) Extension Study of Budesonide Multi-Matrix System (MMX) 6 mg in Maintenance Of Remission In Patients With Ulcerative Colitis.
Bausch Health Americas
NCT00801723
Adherence to Mesalamine Profile for Patients With Inflammatory Bowel Disease
Beth Israel Deaconess Medical Center
NCT01349504
A Trial of Rosiglitazone for Ulcerative Colitis
James Lewis
NCT00065065
Efficacy and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Ulcerative Colitis
AbbVie
NCT02065557
Multi-center Acute Severe Ulcerative Colitis Cohort Study (MASCC)
Johns Hopkins University
NCT03669822
Fecal Biomarker Study for Patients With Ulcerative Colitis
Warner Chilcott
NCT00780507
Pneumococcal Vaccination in Patients With Inflammatory Bowel Disease
Cedars-Sinai Medical Center
NCT00829595
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
Corewell Health West
NCT00467922
Efficacy, Safety and Tolerability of AEB071 in Patients With Active, Moderate to Severe Ulcerative Colitis
Novartis Pharmaceuticals
NCT00572585
A Study to Evaluate Safety and Efficacy of Telotristat Etiprate (LX1606) in Participants With Acute, Mild to Moderate Ulcerative Colitis
Lexicon Pharmaceuticals
NCT01456052
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 32 |
| Phase 3 | 28 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Ulcerative Colitis Trial Landscape
123 indexed Ulcerative Colitis studies · 45 recruiting (37%).
Phase mix: 32 late (III/IV) vs 47 early (I/II).
Top sponsor: Eli Lilly and Company (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Ulcerative Colitis?
PlainTrial tracks 123 US clinical trials for Ulcerative Colitis, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Ulcerative Colitis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.