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A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
NCT06979336 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.
Conditions Studied
Interventions
- DRUG RO7837195
- DRUG RO7837195 Matched Placebo
Study Locations (20)
Other
- Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University — Hangzhou
- PreventaMed, s.r.o. — Olomouc
- Nemocnice Slany — Slaný
California
- Gastro Care Institute — Lancaster
- Medical Associates Research Group, Inc. — San Diego
Lombardy
- Fondazione Poliambulanza Istituto Ospedaliero — Brescia
- ASST Rhodense, Rho Memorial Hospital — Rho
Colorado
- Peak Gastroenterology Associates — Colorado Springs
Florida
- Clinical Research of Osceola, LLC — Kissimmee
New York
- Intercity Gastroenterology — Fresh Meadows
North Carolina
- Monroe Biomedical Research — Monroe
Paraná
- Centro Digestivo de Curitiba — Curitiba
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 224 participants |
| Start Date | 2025-09-29 |
| Est. Completion | 2028-10-31 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06979336
The ClinicalTrials.gov registry entry for NCT06979336 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 224 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Ulcerative Colitis appearing as the primary indexed condition, and to 2 interventions — of which RO7837195 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06979336 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Other, California, Lombardy. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06979336 about?
NCT06979336 is a clinical study titled "A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)". The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.
What is the current status of trial NCT06979336?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 224 participants. The study started on 2025-09-29. Estimated completion is 2028-10-31.
What conditions does trial NCT06979336 study?
This clinical trial studies the following conditions: Ulcerative Colitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06979336?
The interventions under investigation include: RO7837195 (DRUG), RO7837195 Matched Placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06979336?
This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06979336 being conducted?
This trial has 20 study locations across California, Colorado, Florida, New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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