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Total Knee Arthroplasty: later-stage trial registry
14 of 30 indexed Total Knee Arthroplasty trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #519 of 28,707 conditions by registered trial count.
30 US clinical trials · 14 currently recruiting · #519 of 28,707 conditions by registered trial count
Total Knee Arthroplasty: 30 US clinical trials tracked, 14 recruiting.
Total Knee Arthroplasty is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Smith & Nephew, running 3 of these trials.
Enrollment posture brief
Registry condition total-knee-arthroplasty
OPEN 14 | RECR 47% | LATE 6 | EARLY 3 | RANK #519 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Autism (47% recruiting · 105 trials)
Total Knee Arthroplasty lists 14 open slots (47% of 30 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Total Knee Arthroplasty on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Total Knee Arthroplasty is recruiting above its size-band peers.
14 of 30 indexed trials (46.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Total Knee Arthroplasty trials is spread across many organizations.
Smith & Nephew accounts for 3 of 30 trials (10%). 22 distinct sponsors appear on at least one study for this condition label.
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Typical Total Knee Arthroplasty enrolment sits around 118 participants.
Median target enrolment is 118 among the 30 trials that report a genuine target (sentinel values excluded). 12 of those (40%) plan for fewer than 100 participants.
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Total Knee Arthroplasty research is mostly interventional.
23 interventional and 7 observational studies make up this index (76.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
30 total, page 1 of 1
Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty
University of Colorado, Denver
NCT06953375
Medrol Dosepak for Outpatient Total Knee Arthroplasty
Rush University Medical Center
NCT05097976
Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery
Rush University Medical Center
NCT07020312
Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories
VA Office of Research and Development
NCT05288803
Minimal Sedation During Knee Replacement Surgery
Mayo Clinic
NCT07371390
Persona MC vs PS RCT With ROSA
NYU Langone Health
NCT05391828
Investigating Patient Satisfaction With Smart Knee Implants
University of Chicago
NCT06968143
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Vanderbilt University Medical Center
NCT06083480
Intraoperative VR for Older Patients Undergoing TKA
Beth Israel Deaconess Medical Center
NCT04748549
Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty
Hospital for Special Surgery, New York
NCT05981105
Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery
The Cleveland Clinic
NCT06946368
Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)
The Methodist Hospital Research Institute
NCT06640491
A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty
University of California, San Diego
NCT07282782
Observation of Wheeled Device Use After TKA
Stanford University
NCT06080152
Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts
Smith & Nephew
NCT03687593
Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty
Smith & Nephew
NCT03720782
Interventional Study Exploring the Occurrence of Surgical Site Infections.
Molnlycke Health Care AB
NCT06661473
Polyethylene Wear Particle Analysis of TKA
Osaka Metropolitan University
NCT06426641
Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study
Smith & Nephew
NCT03292003
RCT Foley Catheter Study for Elective TJA
Rush University Medical Center
NCT05428020
Single Shot vs 24hr vs 48hr Continuous Adductor Canal Block After TKA
University of Pennsylvania
NCT02730728
A Post-Market, Retrospective Study on 3D Metal Tibial and Femoral Cones
Medacta International
NCT06578897
Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks
University of California, San Diego
NCT02523235
Does Duloxetine Reduce Sub-Acute Pain After Knee Arthroplasty?
Hospital for Special Surgery, New York
NCT02005601
Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Hospital for Special Surgery, New York
NCT01333943
Effect of Ambulatory Continuous Femoral Nerve Blocks on Readiness-for-Discharge Following Total Knee Replacement
University of California, San Diego
NCT00419276
Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty
Wake Forest University Health Sciences
NCT02991404
A Comparison of Subvastus and Midvastus Approaches in Minimally-Invasive Total Knee Arthroplasty
Sinai Hospital of Baltimore
NCT00848133
Return Physical Activities After Total Knee Arthroplasty
Cincinnati Sportsmedicine Research and Education Foundation
NCT04746144
Impact of Prehabilitation in Total Knee Replacement
Allina Health System
NCT01844934
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 1 |
| Phase 4 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Total Knee Arthroplasty records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Total Knee Arthroplasty trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Total Knee Arthroplasty page
30 registered trials, 14 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 14 Total Knee Arthroplasty trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Smith & Nephew sponsors the most Total Knee Arthroplasty trials on record, review their full trial history before evaluating a specific study. See Smith & Nephew's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Total Knee Arthroplasty condition card totals 30 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.