Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 18 recruiting now official registry

AML clinical trials

18 of 30 indexed AML trials are currently recruiting.

30 US clinical trials · 18 currently recruiting

AML is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 25 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 3 of these trials.

The research picture

AML has 30 registered US clinical trials, 18 of them open to new participants right now, about 60% of the total.

18
recruiting participants now
60%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: M.D. Anderson Cancer Center
Phase 118Phase 27Phase 31

Active & Recent Trials

30 total, page 1 of 1

RECRUITING 1,500 participants

Familial Investigations of Childhood Cancer Predisposition

St. Jude Children's Research Hospital

NCT03050268

RECRUITING 1,000 participants

A Long Term Follow-up Study of TScan TCR-T Products

TScan Therapeutics

NCT06976736

RECRUITING Phase 1 171 participants

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Kura Oncology

NCT06001788

RECRUITING Phase 2 80 participants

A Randomized Study to Compare Post-transplant Cyclophosphamide, Sirolimus, Ruxolitinib and Post-transplant Cyclophosphamide, Sirolimus, Mycophenolate Mofetil to Prevent Graft Versus Host Disease

M.D. Anderson Cancer Center

NCT06973668

RECRUITING Phase 1 75 participants

A Study of TSC-100 and TSC-101 in AML, ALL and MDS in Patients Undergoing Allogeneic Peripheral Blood Stem Transplantation

TScan Therapeutics

NCT05473910

RECRUITING Phase 2 70 participants

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Masonic Cancer Center, University of Minnesota

NCT05735717

RECRUITING Phase 2 70 participants

Cardioprotection in AML

University of Virginia

NCT04977180

RECRUITING Phase 1 68 participants

Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML

Washington University School of Medicine

NCT06158828

RECRUITING Phase 2 64 participants

A Randomized Phase II Study of Hyperbaric Oxygen in Improving Engraftment in Umbilical Cord Blood Stem Cell Transplant

University of Rochester

NCT03739502

RECRUITING Phase 1 54 participants

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

Therapeutic Advances in Childhood Leukemia Consortium

NCT05476770

RECRUITING Phase 1 50 participants

UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy

University of Alabama at Birmingham

NCT06047886

RECRUITING Phase 2 37 participants

A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid Malignancies

Franziska Wachter

NCT05796570

RECRUITING Phase 1 35 participants

CC-486 and Venetoclax for Acute Myeloid Leukemia

University of Colorado, Denver

NCT05287568

RECRUITING Phase 2 31 participants

Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

Memorial Sloan Kettering Cancer Center

NCT04644016

RECRUITING 30 participants

Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

Children's Hospital Medical Center, Cincinnati

NCT06131801

RECRUITING Phase 1 22 participants

Revumenib in Combination With 7+3 + Midostaurin in AML

Richard Stone, MD

NCT06313437

RECRUITING Phase 1 18 participants

CER-1236 in Patients With Acute Myeloid Leukemia (AML)

CERo Therapeutics Holdings

NCT06834282

RECRUITING Phase 1 18 participants

Study of NEROFE, a Novel Hormone-Peptide in Adult Patients With Advanced MDS and AML

Immune System Key

NCT04365179

ACTIVE NOT RECRUITING Phase 3 153 participants

Study of Iomab-B vs. Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia

Actinium Pharmaceuticals

NCT02665065

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML

Treadwell Therapeutics

NCT04730258

ACTIVE NOT RECRUITING Phase 2 42 participants

A Phase II Study of Vibecotamab (XmAb14045) for MRD- Positive AML and MDS After Hypomethylating Agent Failure

M.D. Anderson Cancer Center

NCT05285813

ACTIVE NOT RECRUITING Phase 1 3 participants

ALLG AMLM26 INTERCEPT (Investigating Novel Therapy to Target Early Relapse and Clonal Evolution as Pre-emptive Therapy in AML): A Multi-arm, Precision-based, Recursive, Platform Trial

M.D. Anderson Cancer Center

NCT06664879

COMPLETED Phase 1 54 participants

Study of Bexarotene in Patients With Acute Myeloid Leukemia

Abramson Cancer Center at Penn Medicine

NCT00316030

COMPLETED 50 participants

Ascorbic Acid Levels in MDS, AML, and CMML Patients

Van Andel Research Institute

NCT03526666

COMPLETED Early Phase 1 30 participants

Pilot Study of Non-Myeloablative, HLA-Matched Allogeneic Stem Cell Transplantation for Pediatric Hematopoietic Malignancies

National Cancer Institute (NCI)

NCT00013533

COMPLETED Phase 1 21 participants

A Study of Selinexor in Combination With Daunorubicin and Cytarabine for Untreated AML

H. Lee Moffitt Cancer Center and Research Institute

NCT02403310

COMPLETED Phase 1 21 participants

DEPLETHINK - LymphoDEPLEtion and THerapeutic Immunotherapy With NKR-2

Celyad Oncology

NCT03466320

COMPLETED Phase 1 16 participants

Sirolimus in Combination With MEC in High Risk Myeloid Leukemias

Abramson Cancer Center at Penn Medicine

NCT00780104

COMPLETED Phase 1 14 participants

CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory AML or MDS

Cyclacel Pharmaceuticals

NCT04017546

COMPLETED Phase 1 3 participants

Decitabine Maintenance in Elderly Acute Myeloid Leukemia Patients

University of Utah

NCT01149408

Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 7
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the AML Trial Landscape

30 indexed AML studies · 18 recruiting (60%).

Phase mix: 1 late (III/IV) vs 25 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (3 trials), 9 others listed. 30 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for AML?

PlainTrial tracks 30 US clinical trials for AML, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for AML?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.