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NCT05097976 · ClinicalTrials.gov registry record · Phase 4
Medrol Dosepak for Outpatient Total Knee Arthroplasty
A Phase 4 study of Total Knee Arthroplasty, sponsored by Rush University Medical Center.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 420
- Enrollment target
- 1
- Study location
NCT05097976: Recruiting Phase 4 study of Total Knee Arthroplasty, sponsored by Rush University Medical Center.
NCT05097976 is a Phase 4 study of Total Knee Arthroplasty that is actively recruiting participants, run by Rush University Medical Center. The registered enrollment target is 420 participants, above the 280-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (50% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05097976, a Phase 4 study of Total Knee Arthroplasty, is actively recruiting participants, sponsored by Rush University Medical Center.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 420 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA). We hypothesize that administration of an oral methylprednisolone taper starting on postoperative day 1 (POD 1) following TKA will be associated with improved pain and decreased opioid use, nausea, and complications at POD1-7, as compared to similar patients who receive placebo. Additionally, those taking methylprednisolone will report decreased pain and greater objective functional outcomes at 3 and 6 weeks postoperatively as compared to controls.
Primary Outcome
Relative difference in cumulative opioid consumption at Post-op day 7, measured in morphine equivalents.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Methylprednisolone
Study Locations (1)
Illinois
- Rush Oak Brook Outpatient Center - Oak Brook
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 420 participants |
| Start Date | 2022-03-01 |
| Est. Completion | 2026-12 |
| Phase | Phase 4 |
What NCT05097976 shows while recruiting
NCT05097976 is an interventional study that assigns participants to a tested intervention. The registered 420 participants enrollment target is mid-sized for trials with a published cap, above the 280-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (50% higher).
The record links to 1 condition, with Total Knee Arthroplasty appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05097976 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT05097976 about?
NCT05097976 is a clinical study titled "Medrol Dosepak for Outpatient Total Knee Arthroplasty". The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA). We hypothesize that administration of an oral methylprednisolone taper st...
What is the current status of trial NCT05097976?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 420 participants. The study started on 2022-03-01. Estimated completion is 2026-12.
What conditions does trial NCT05097976 study?
This clinical trial studies the following conditions: Total Knee Arthroplasty.
What interventions are being tested in trial NCT05097976?
The interventions under investigation include: Placebo (DRUG), Methylprednisolone (DRUG).
Who is sponsoring clinical trial NCT05097976?
This trial is sponsored by Rush University Medical Center, which has 320 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05097976 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Total Knee Arthroplasty
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05097976's enrollment target sits among peer trials
420 3rd of 29 higher than 27 of 29 other Total Knee Arthroplasty trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Total Knee Arthroplasty trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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