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NCT06640491 · ClinicalTrials.gov registry record · Phase 1
Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)
A Phase 1 study of Total Knee Arthroplasty, sponsored by The Methodist Hospital Research Institute.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06640491: Recruiting Phase 1 study of Total Knee Arthroplasty, sponsored by The Methodist Hospital Research Institute.
NCT06640491 is a Phase 1 study of Total Knee Arthroplasty that is actively recruiting participants, run by The Methodist Hospital Research Institute. The registered enrollment target is 40 participants, below the 294-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06640491, a Phase 1 study of Total Knee Arthroplasty, is actively recruiting participants, sponsored by The Methodist Hospital Research Institute.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at Houston Methodist Hospital. The main questions it aims to answer are: Does IO administration of vancomycin and cefazolin protect against perioperative exposure risks? Is there a difference in post-operative complication rates between IV and IO administration of these drugs? Participants will be randomized to receive either the standard of care IV administration of Vancomycin and Cefazolin, or the IO administration of Vancomycin and Cefazolin.
Primary Outcome
Participants charts will be reviewed at 30 days postop and 90 days postop to determine if there were any infections.
Conditions Studied
Interventions
- DRUG IO Administration of Cefazolin
- DRUG IO Administration of Vancomycin
- DRUG IV Administration of Cefazolin
- DRUG IV Administration of Vancomycin
Study Locations (1)
Texas
- Houston Methodist Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-05-15 |
| Est. Completion | 2035-12-01 |
| Phase | Phase 1 |
What NCT06640491 shows while recruiting
NCT06640491 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 294-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (86% lower).
The record links to 1 condition, with Total Knee Arthroplasty appearing as the primary indexed condition, and to 4 interventions - of which IO Administration of Cefazolin is the first listed.
NCT06640491 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06640491 about?
NCT06640491 is a clinical study titled "Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)". The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at Houston Methodist Hospital. The main questions it aims to answer are: Does I...
What is the current status of trial NCT06640491?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2025-05-15. Estimated completion is 2035-12-01.
What conditions does trial NCT06640491 study?
This clinical trial studies the following conditions: Total Knee Arthroplasty.
What interventions are being tested in trial NCT06640491?
The interventions under investigation include: IO Administration of Cefazolin (DRUG), IO Administration of Vancomycin (DRUG), IV Administration of Cefazolin (DRUG), IV Administration of Vancomycin (DRUG).
Who is sponsoring clinical trial NCT06640491?
This trial is sponsored by The Methodist Hospital Research Institute, which has 126 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06640491 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Total Knee Arthroplasty
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06640491's enrollment target sits among peer trials
40 28th of 29 higher than 2 of 29 other Total Knee Arthroplasty trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Total Knee Arthroplasty trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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