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NCT06640491 · ClinicalTrials.gov registry record · Phase 1
Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)
A Phase 1 study of Total Knee Arthroplasty, sponsored by The Methodist Hospital Research Institute.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06640491 is a Phase 1 study of Total Knee Arthroplasty that is actively recruiting participants, run by The Methodist Hospital Research Institute. The registered enrollment target is 40 participants, below the 294-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06640491, a Phase 1 study of Total Knee Arthroplasty, is actively recruiting participants, sponsored by The Methodist Hospital Research Institute.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at Houston Methodist Hospital. The main questions it aims to answer are: Does IO administration of vancomycin and cefazolin protect against perioperative exposure risks? Is there a difference in post-operative complication rates between IV and IO administration of these drugs? Participants will be randomized to receive either the standard of care IV administration of Vancomycin and Cefazolin, or the IO administration of Vancomycin and Cefazolin.
Conditions Studied
Interventions
- DRUG IO Administration of Cefazolin
- DRUG IO Administration of Vancomycin
- DRUG IV Administration of Cefazolin
- DRUG IV Administration of Vancomycin
Study Locations (1)
Texas
- Houston Methodist Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-05-15 |
| Est. Completion | 2035-12-01 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06640491
The ClinicalTrials.gov registry entry for NCT06640491 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 294-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (86% lower). The listed sponsor is The Methodist Hospital Research Institute, which has 126 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Total Knee Arthroplasty appearing as the primary indexed condition, and to 4 interventions - of which IO Administration of Cefazolin is the first listed.
NCT06640491 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.
Frequently Asked Questions
What is clinical trial NCT06640491 about?
NCT06640491 is a clinical study titled "Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)". The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at Houston Methodist Hospital. The main questions it aims to answer are: Does I...
What is the current status of trial NCT06640491?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2025-05-15. Estimated completion is 2035-12-01.
What conditions does trial NCT06640491 study?
This clinical trial studies the following conditions: Total Knee Arthroplasty.
What interventions are being tested in trial NCT06640491?
The interventions under investigation include: IO Administration of Cefazolin (DRUG), IO Administration of Vancomycin (DRUG), IV Administration of Cefazolin (DRUG), IV Administration of Vancomycin (DRUG).
Who is sponsoring clinical trial NCT06640491?
This trial is sponsored by The Methodist Hospital Research Institute, which has 126 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06640491 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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