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ClinicalTrials.gov 12 recruiting now official registry

Acute Myeloid Leukemia (AML) clinical trials

12 of 30 indexed Acute Myeloid Leukemia (AML) trials are currently recruiting.

30 US clinical trials · 12 currently recruiting

Acute Myeloid Leukemia (AML) is the subject of 30 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is St. Jude Children's Research Hospital, running 3 of these trials.

The research picture

Acute Myeloid Leukemia (AML) has 30 registered US clinical trials, 12 of them open to new participants right now, about 40% of the total.

12
recruiting participants now
40%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
3
top sponsor: St. Jude Children's Research Hospital
Phase 112Phase 211Phase 35

Active & Recent Trials

30 total, page 1 of 1

RECRUITING Phase 3 1,300 participants

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Kura Oncology

NCT07007312

RECRUITING NA 200 participants

Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

Masonic Cancer Center, University of Minnesota

NCT01962636

RECRUITING Phase 2 140 participants

Monitoring, Detoxifying, and Rebalancing Metals During Acute Myeloid Leukemia (AML) Therapy, a Phase 2 Randomized Study

M.D. Anderson Cancer Center

NCT06811233

RECRUITING Phase 2 108 participants

Clinical Trial of BP1001 in Combination With With Venetoclax Plus Decitabine in AML

Bio-Path Holdings

NCT02781883

RECRUITING Phase 1 105 participants

A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML)

Solu Therapeutics

NCT06950034

RECRUITING Phase 1 80 participants

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

M.D. Anderson Cancer Center

NCT05092451

RECRUITING Phase 2 75 participants

Ivosidenib as Post-HSCT Maintenance for AML

Massachusetts General Hospital

NCT06707493

RECRUITING Phase 1 39 participants

APVO436 Phase 1b/2 Study in Patients With Newly Diagnosed AML

Aptevo Therapeutics

NCT06634394

RECRUITING Phase 1 36 participants

A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)

Memorial Sloan Kettering Cancer Center

NCT05756777

RECRUITING Phase 2 30 participants

A Study of Azacitidine and Venetoclax in People With Acute Myeloid Leukemia (AML)

Memorial Sloan Kettering Cancer Center

NCT06773208

RECRUITING Phase 1 16 participants

Niclosamide in Pediatric Patients With Relapsed and Refractory AML

Stanford University

NCT05188170

RECRUITING Early Phase 1 8 participants

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06398457

ACTIVE NOT RECRUITING Phase 3 443 participants

A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy

AbbVie

NCT02993523

ACTIVE NOT RECRUITING Phase 1 260 participants

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

Eli Lilly and Company

NCT04603001

ACTIVE NOT RECRUITING Phase 2 170 participants

Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

St. Jude Children's Research Hospital

NCT02790515

ACTIVE NOT RECRUITING Phase 3 112 participants

A Study of Oral Venetoclax Tablets and Oral Azacitidine as Maintenance Therapy in Adult Participants With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy

AbbVie

NCT04102020

ACTIVE NOT RECRUITING Phase 1 102 participants

Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN

Jacqueline Garcia, MD

NCT03613532

ACTIVE NOT RECRUITING Phase 1 70 participants

A Study of Gilteritinib, Venetoclax and Azacitidine as a Combined Treatment for People Newly Diagnosed With Acute Myeloid Leukemia

Astellas Pharma Global Development

NCT05520567

ACTIVE NOT RECRUITING Phase 2 69 participants

TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

St. Jude Children's Research Hospital

NCT03849651

ACTIVE NOT RECRUITING Phase 2 59 participants

A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant

Memorial Sloan Kettering Cancer Center

NCT04872595

COMPLETED Phase 3 381 participants

Study of Elacytarabine Versus Investigator's Choice in Patients With Late Stage Acute Myeloid Leukaemia (AML)

Clavis Pharma

NCT01147939

COMPLETED Phase 1 138 participants

Tagraxofusp in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm or Acute Myeloid Leukemia

Stemline Therapeutics

NCT02113982

COMPLETED Phase 2 98 participants

A Study of ASP2215 (Gilteritinib), Administered as Maintenance Therapy Following Induction/Consolidation Therapy for Subjects With FMS-like Tyrosine Kinase 3 (FLT3/ITD) Acute Myeloid Leukemia (AML) in First Complete Remission

Astellas Pharma Global Development

NCT02927262

COMPLETED Phase 3 60 participants

A Study of the Effectiveness of Venetoclax in Combination With Azacitidine or Decitabine in an Outpatient Setting in Patients With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy

AbbVie

NCT03941964

COMPLETED Phase 2 40 participants

Treosulfan/Fludarabine/Low Dose TBI as a Preparative Regimen for Children With AML/MDS Undergoing Allo HCT

Center for International Blood and Marrow Transplant Research

NCT01772953

COMPLETED Phase 1 36 participants

Transplantation of NiCord®, Umbilical Cord Blood-derived Ex Vivo Expanded Cells, in Patients With HM

Gamida Cell

NCT01816230

COMPLETED Phase 1 19 participants

Selinexor With Fludarabine and Cytarabine for Treatment of Refractory or Relapsed Leukemia or Myelodysplastic Syndrome

St. Jude Children's Research Hospital

NCT02212561

COMPLETED Phase 2 10 participants

Peptide Vaccinations to Treat Patients With Low-Risk Myeloid Cancers

National Heart, Lung, and Blood Institute (NHLBI)

NCT00488592

COMPLETED NA 10 participants

Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders

Massachusetts General Hospital

NCT01758042

COMPLETED Phase 2 4 participants

Wilm's Tumor 1 (WT1) Peptide Vaccine for High Risk Hematologic Malignancy

National Heart, Lung, and Blood Institute (NHLBI)

NCT00433745

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 11
Phase 3 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Myeloid Leukemia (AML) Trial Landscape

30 indexed Acute Myeloid Leukemia (AML) studies · 12 recruiting (40%).

Phase mix: 5 late (III/IV) vs 23 early (I/II).

Top sponsor: St. Jude Children's Research Hospital (3 trials), 9 others listed. 30 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Myeloid Leukemia (AML)?

PlainTrial tracks 30 US clinical trials for Acute Myeloid Leukemia (AML), of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Myeloid Leukemia (AML)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.