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NCT07282782 · ClinicalTrials.gov registry record · Phase 4
A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty
A Phase 4 study of Total Knee Arthroplasty, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07282782: Recruiting Phase 4 study of Total Knee Arthroplasty, sponsored by University of California, San Diego.
NCT07282782 is a Phase 4 study of Total Knee Arthroplasty that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 30 participants, below the 294-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07282782, a Phase 4 study of Total Knee Arthroplasty, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Periprosthetic joint infection (PJI) is a national health crisis and leads to very poor outcomes for patients undergoing elective joint replacement. Within the realm of elective total knee arthroplasty (TKA), various methods of infection prophylaxis are in place. These include sterile precautions, would/tissue handling, and antibiotic prophylaxis. With respect to the latter, various approaches have been utilized including intravenous and intraosseous administration of vancomycin, preoperatively. Intraosseous administration does require another wound and a specific device to administer. We proposed that intraarticular injection of vancomycin is non-inferior to intraosseous administration, thus reducing wounds, time, and cost.
Conditions Studied
Interventions
- DRUG Vancomycin
Study Locations (1)
California
- University of California, San Diego - San Diego
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2024-06-10 |
| Est. Completion | 2028-12-31 |
| Phase | Phase 4 |
What NCT07282782 shows while recruiting
NCT07282782 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 294-participant average among 29 other Total Knee Arthroplasty trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Total Knee Arthroplasty appearing as the primary indexed condition, and to 1 intervention - of which Vancomycin is the first listed.
NCT07282782 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07282782 about?
NCT07282782 is a clinical study titled "A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty". Periprosthetic joint infection (PJI) is a national health crisis and leads to very poor outcomes for patients undergoing elective joint replacement. Within the realm of elective total knee arthroplasty (TKA), various methods of infection prophylaxis are in place. These include sterile precautions, w...
What is the current status of trial NCT07282782?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 30 participants. The study started on 2024-06-10. Estimated completion is 2028-12-31.
What conditions does trial NCT07282782 study?
This clinical trial studies the following conditions: Total Knee Arthroplasty.
What interventions are being tested in trial NCT07282782?
The interventions under investigation include: Vancomycin (DRUG).
Who is sponsoring clinical trial NCT07282782?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07282782 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07282782's enrollment target sits among peer trials
30 29th of 29 higher than 1 of 29 other Total Knee Arthroplasty trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Total Knee Arthroplasty trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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