Smith & Nephew
Open enrollment with a later-stage pipeline tilt
According to ClinicalTrials.gov-derived indexes, Smith & Nephew sits in the top decile of US sponsors by registered trial count (#300 of 15,742 sponsors by registered trial count).
Smith & Nephew: 72 sponsored US clinical trials, 3 recruiting.
Smith & Nephew sponsors 72 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 39 completed. 4 of these trials are in Phase 3-4 (later-stage) and 0 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Total Knee Arthroplasty, with 3 trials.
Top-decile sponsor footprint
Smith & Nephew ranks in the top decile of sponsors by registered trial count (#300 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.
Trial completion reliability score
39 of 59 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (66.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.
Open and recent trials
72 total, page 1 of 2
AETOS Shoulder System
NCT06319911
Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry
NCT05915078
Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
NCT05444465
A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
NCT06564636
To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System.
NCT04849884
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
NCT05197036
Safety and Effectiveness Study of OR3O™ Dual Mobility System in THA
NCT04325022
Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty
NCT03720782
Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts
NCT03687593
JOURNEY II XR Safety and Effectiveness PMCF
NCT03136887
JOURNEY™ II CR Total Knee System
NCT02440672
LEGION Hinge Safety and Efficacy Study
NCT02445443
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
NCT07199738
Safety and Performance Study of the FAST-FIX FLEX System for Meniscal Repairs and Meniscal Transplantations
NCT04903106
Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures
NCT04786119
Safety of Treatment of Shoulder Repair
NCT04552119
REGENETEN™ Bioinductive Implant System in Full-thickness Tears
NCT04450342
Circumferential Compression STITCH Repairs of Complex and Horizontal Cleavage Meniscal Tears
NCT04361487
Safety and Performance of ENTACT Septal Staple System for Septoplasty
NCT04392583
Safety Study of Treatment of Leg Fractures
NCT03881241
Safety and Performance of MICRORAPTOR™ Suture Anchors in Shoulder and Hip
NCT03985839
PMCF Study on PEEK Suture Anchors for Hip Indications
NCT03814044
Safety and Performance of JOURNEY™ II Cruciate Retaining (CR) Total Knee System (TKS)
NCT03885531
Safety and Performance of PEEK Anchors in Extremities
NCT03782298
PMCF Study on PEEK Suture Anchors for Shoulder Indications
NCT03826667
Treatment of Partial-Thickness Rotator Cuff Tears
NCT03734536
Safety and Performance of Journey II XR Total Knee System
NCT03798847
Safety and Performance of the TFCC FastFix in the Wrist
NCT03756714
Safety Study of Femoral Neck Fracture System
NCT03721835
S&P of Q-Fix™ All-Suture Anchor System
NCT03594071
Safety and Performance of the Journey™ II UNI Unicompartmental Knee System
NCT03768128
Safety and Performance of Journey II BCS Total Knee System Patient Reported Outcome Measures
NCT03903731
R3 Delta Ceramic Acetabular System PAS U.S.
NCT03056534
Navio With Total Knee Arthroplasty
NCT03317834
BIOSURE™ RG Knee Safety & Performance Study
NCT03519555
Agili-C™ Implant Performance Evaluation
NCT03299959
Clinical Evaluation of the Integra® Titan™ Modular Shoulder System Generation 2.5 for Primary Shoulder Joint Replacement
NCT03250767
A Retrospective Study of the Navio Robotic-assisted Surgical System
NCT03072459
Evaluation Of An Advanced Borderless Dressing
NCT03146845
Clinical Evaluation of the TITAN™ Total Shoulder System
NCT03245320
Predictors of Early Success From Circumferential Compression STITCH Meniscal Repairs
NCT03097744
Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study
NCT03292003
Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT Setting
NCT02820766
Study of SANTYL® vs Hydrogel (SoloSite®) for Pressure Ulcers
NCT02718625
Achilles Tendon Repair With Bioinductive Implant
NCT02811003
Rotation Medical Bioinductive Implant Database Registry
NCT02784600
REDAPT Retrospective-Prospective Modular Stem Study
NCT02661620
Use of Santyl in Diabetic Foot Ulcers
NCT02581488
Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT)
NCT02470806
Study of Suture Repair of Torn Meniscus in the Knee
NCT02237001
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 4 | 4 |
Where Smith & Nephew enrollment is open (later-stage tilt)
3 recruiting of 72 indexed (4% open); 39 completed (54%).
Phase mix: 4 late (III/IV) vs 0 early (I/II) (later-stage heavy).
Top condition: Total Knee Arthroplasty (3 trials), 9 others listed.
How open-pipeline share is computed
Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.
Smith & Nephew: open-pipeline peers nationwide
Peers matched on 72 registered trials and 4% open enrollment, not the therapeutic-area sidebar.
Smith & Nephew sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.
Sponsors near 72 trials (± recruiting share)
- H. Lundbeck A/S · 72 trials · 7% recruiting
- University of California, Berkeley · 72 trials · 18% recruiting
- Denver Health and Hospital Authority · 73 trials · 5% recruiting
- Hugo W. Moser Research Institute at Kennedy Krieger · 73 trials · 23% recruiting
Sponsors near 4% open enrollment (± trial volume)
- Akebia Therapeutics · 4% recruiting · 24 trials
- Dentsply Sirona Implants and Consumables · 4% recruiting · 24 trials
- National Institute on Drug Abuse (NIDA) · 4% recruiting · 335 trials
- Medtronic - MITG · 4% recruiting · 119 trials
Related
What to do with this Smith & Nephew page
72 registered trials is a research-attention snapshot, not an endorsement of Smith & Nephew or any single study.
- 3 of Smith & Nephew's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
- Total Knee Arthroplasty is the condition Smith & Nephew studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Total Knee Arthroplasty trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Smith & Nephew pipeline card: 72 registered trials from official public datasets.Report a data error.