Smith & Nephew
Smith & Nephew sponsors 72 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 39 completed. 4 of these trials are in Phase 3-4 (later-stage) and 0 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Total Knee Arthroplasty, with 3 trials.
Trial Pipeline
72 total, page 1 of 2
AETOS Shoulder System
NCT06319911
Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry
NCT05915078
Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
NCT05444465
A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
NCT06564636
To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System.
NCT04849884
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
NCT05197036
Safety and Effectiveness Study of OR3O™ Dual Mobility System in THA
NCT04325022
Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty
NCT03720782
Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts
NCT03687593
JOURNEY II XR Safety and Effectiveness PMCF
NCT03136887
JOURNEY™ II CR Total Knee System
NCT02440672
LEGION Hinge Safety and Efficacy Study
NCT02445443
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
NCT07199738
Safety and Performance Study of the FAST-FIX FLEX System for Meniscal Repairs and Meniscal Transplantations
NCT04903106
Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures
NCT04786119
Safety of Treatment of Shoulder Repair
NCT04552119
REGENETEN™ Bioinductive Implant System in Full-thickness Tears
NCT04450342
Circumferential Compression STITCH Repairs of Complex and Horizontal Cleavage Meniscal Tears
NCT04361487
Safety and Performance of ENTACT Septal Staple System for Septoplasty
NCT04392583
Safety Study of Treatment of Leg Fractures
NCT03881241
Safety and Performance of MICRORAPTOR™ Suture Anchors in Shoulder and Hip
NCT03985839
PMCF Study on PEEK Suture Anchors for Hip Indications
NCT03814044
Safety and Performance of JOURNEY™ II Cruciate Retaining (CR) Total Knee System (TKS)
NCT03885531
Safety and Performance of PEEK Anchors in Extremities
NCT03782298
PMCF Study on PEEK Suture Anchors for Shoulder Indications
NCT03826667
Treatment of Partial-Thickness Rotator Cuff Tears
NCT03734536
Safety and Performance of Journey II XR Total Knee System
NCT03798847
Safety and Performance of the TFCC FastFix in the Wrist
NCT03756714
Safety Study of Femoral Neck Fracture System
NCT03721835
S&P of Q-Fix™ All-Suture Anchor System
NCT03594071
Safety and Performance of the Journey™ II UNI Unicompartmental Knee System
NCT03768128
Safety and Performance of Journey II BCS Total Knee System Patient Reported Outcome Measures
NCT03903731
R3 Delta Ceramic Acetabular System PAS U.S.
NCT03056534
Navio With Total Knee Arthroplasty
NCT03317834
BIOSURE™ RG Knee Safety & Performance Study
NCT03519555
Agili-C™ Implant Performance Evaluation
NCT03299959
Clinical Evaluation of the Integra® Titan™ Modular Shoulder System Generation 2.5 for Primary Shoulder Joint Replacement
NCT03250767
A Retrospective Study of the Navio Robotic-assisted Surgical System
NCT03072459
Evaluation Of An Advanced Borderless Dressing
NCT03146845
Clinical Evaluation of the TITAN™ Total Shoulder System
NCT03245320
Predictors of Early Success From Circumferential Compression STITCH Meniscal Repairs
NCT03097744
Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study
NCT03292003
Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT Setting
NCT02820766
Study of SANTYL® vs Hydrogel (SoloSite®) for Pressure Ulcers
NCT02718625
Achilles Tendon Repair With Bioinductive Implant
NCT02811003
Rotation Medical Bioinductive Implant Database Registry
NCT02784600
REDAPT Retrospective-Prospective Modular Stem Study
NCT02661620
Use of Santyl in Diabetic Foot Ulcers
NCT02581488
Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT)
NCT02470806
Study of Suture Repair of Torn Meniscus in the Knee
NCT02237001
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 4 | 4 |
What the Pipeline for Smith & Nephew Shows
According to the ClinicalTrials.gov registry, Smith & Nephew is linked to 72 US clinical trials across every stage of research activity. Of those, 3 studies are currently recruiting, about 4% of the sponsor's indexed portfolio, and 39 are already marked complete, representing roughly 54% of the total.
The phase mix for Smith & Nephew reports 4 late-stage studies (Phase 3 and Phase 4 combined) and 0 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Smith & Nephew is Total Knee Arthroplasty with 3 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.