Smith & Nephew
Trial Pipeline
AETOS Shoulder System
NCT06319911
Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry
NCT05915078
Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears
NCT05444465
A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
NCT06564636
To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System.
NCT04849884
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
NCT05197036
Safety and Effectiveness Study of OR3O™ Dual Mobility System in THA
NCT04325022
Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty
NCT03720782
Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts
NCT03687593
JOURNEY II XR Safety and Effectiveness PMCF
NCT03136887
JOURNEY™ II CR Total Knee System
NCT02440672
LEGION Hinge Safety and Efficacy Study
NCT02445443
Safety and Performance of Journey II BCS Total Knee System Patient Reported Outcome Measures
NCT03903731
R3 Delta Ceramic Acetabular System PAS U.S.
NCT03056534
Evaluation Of An Advanced Borderless Dressing
NCT03146845
Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study
NCT03292003
Achilles Tendon Repair With Bioinductive Implant
NCT02811003
PICO Breast Reduction Clinical Study Looking at Incision Healing Complications
NCT01640366
Trial of Versajet Compared With Conventional Treatment in Acute and Chronic Wounds
NCT01050673
Ankle Joint Replacement Outcomes Study
NCT00503438
A Safety and Efficacy Study of the Birmingham Hip Resurfacing System
NCT00611585
What the Pipeline for Smith & Nephew Shows
According to the ClinicalTrials.gov registry, Smith & Nephew is linked to 52 US clinical trials across every stage of research activity. Of those, 34 studies are currently recruiting — about 65% of the sponsor's indexed portfolio — and 9 are already marked complete, representing roughly 17% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for Smith & Nephew reports 0 late-stage studies (Phase 3 and Phase 4 combined) and 0 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for Smith & Nephew is Total Knee Arthroplasty with 3 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.