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Rheumatoid Arthritis clinical trials
37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting.
199 US clinical trials · 37 currently recruiting
Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.
The research picture
Rheumatoid Arthritis has 199 registered US clinical trials, 37 of them open to new participants right now, about 19% of the total.
- 37
- recruiting participants now
- 19%
- of trials open to enrollment
- 32
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Zimmer Biomet
Active & Recent Trials
199 total, page 2 of 4
Persona Ti-Nidium Post-Market Clinical Follow-up
Zimmer Biomet
NCT04817969
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
Zimmer Biomet
NCT01480440
Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
Zimmer Biomet
NCT01307384
Database Retrieval for the Comprehensive Shoulder
Zimmer Biomet
NCT03409718
Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
Novartis Pharmaceuticals
NCT06293365
The Immunogenicity and Safety of Zostavax® and Shingrix® in Rheumatoid Arthritis Patients Using Abatacept
Kevin Winthrop
NCT03604406
Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System
Zimmer Biomet
NCT03626038
Zimmer Trabecular Metal Total Ankle PMCF
Zimmer Biomet
NCT02038140
A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis
Immunovant Sciences
NCT06754462
Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity
Brigham and Women's Hospital
NCT05715463
Utilizing MRI for Earlier Diagnosis of Rheumatoid Arthritis
Mayo Clinic
NCT03841279
Study of GS-0272 in Participants With Rheumatoid Arthritis
Gilead Sciences
NCT06031415
A Study of LY3541860 in Adult Participants With Moderately to Severely Active Rheumatoid Arthritis
Eli Lilly and Company
NCT06859294
Discovering the Antecedents of Rheumatoid Arthritis Flare
Rockefeller University
NCT02051114
Long Term Extension of Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)
SetPoint Medical Corporation
NCT04862117
A Clinical Study to Assess the Efficacy of Cannabigerol in Patients with Active Rheumatoid Arthritis.
Raphael Pharma
NCT06513507
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs Hydroxychloroquine
Brigham and Women's Hospital
NCT04691505
Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular Endpoints
Brigham and Women's Hospital
NCT04772248
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tocilizumab vs Abatacept
Brigham and Women's Hospital
NCT04529863
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept
Brigham and Women's Hospital
NCT04529876
A Study to Understand How Effective is Tofacitinib When Compared to Other Advanced Treatments in Patients With Rheumatoid Arthritis
Pfizer
NCT06418529
Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids
University of Alabama at Birmingham
NCT01378689
Study of Human Anti-TNF Monoclonal Antibody D2E7 in Subjects With Active Rheumatoid Arthritis
Abbott
NCT00049751
Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions: The Corrona CERTAIN Sub-study
CorEvitas
NCT01625650
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis
R-Pharm International
NCT03120949
Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis
UCB Pharma
NCT00717236
Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement
DePuy Orthopaedics
NCT00306930
A Study of Baricitinib in Participants With Rheumatoid Arthritis
Eli Lilly and Company
NCT04086745
Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF Therapy
Bristol-Myers Squibb
NCT00124982
A Study to Compare Subcutaneous Versus Intravenous Administration of RoActemra/Actemra (Tocilizumab) in Participants With Moderate to Severe Active Rheumatoid Arthritis
Hoffmann-La Roche
NCT01194414
Genetic Registry for Rheumatoid Arthritis
Northwell Health
NCT00069472
Study of Families With Twins or Siblings Discordant for Rheumatic Disorders
National Institute of Environmental Health Sciences (NIEHS)
NCT00055055
Development and Evaluation of A Mailed Arthritis Self-Management Program
University of North Carolina
NCT00448474
Long Term Open Label Continuation Study
Abbott
NCT00195650
Long-term Follow-up Study of GLPG0634 in Active Rheumatoid Arthritis Participants
Galapagos
NCT02065700
A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis
Hoffmann-La Roche
NCT01232569
Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Anti-TNFα Agents
Novartis Pharmaceuticals
NCT01377012
Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis
University of Nebraska
NCT01156155
Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory Arthritis
University of Arizona
NCT00796809
A Study in Participants With Moderate to Severe Rheumatoid Arthritis
Eli Lilly and Company
NCT01711359
Assess Structural Damage in Rheumatoid Arthritis Using Biomarkers and Radiography
Care Arthritis
NCT01476956
A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate Treatment
Hoffmann-La Roche
NCT00810199
Abatacept With Methotrexate- Phase IIB
Bristol-Myers Squibb
NCT00162266
Comparative Analysis of Outcomes Among Patients Initiating Xeljanz in Combination With Oral MTX Who Withdraw MTX Versus Continue MTX
Pfizer
NCT03975790
Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001885
Study of Etanercept Monotherapy vs Methotrexate Monotherapy for Maintenance of Rheumatoid Arthritis Remission
Amgen
NCT02373813
Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH)
Sanofi
NCT02332590
Study to Characterize the Pharmacokinetics of a Single Dose of SC Abatacept 125 mg Using the BD Autoinjector or the Prefilled Syringe
Bristol-Myers Squibb
NCT01890473
Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy
US Department of Veterans Affairs
NCT00405275
A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis
Hoffmann-La Roche
NCT01382940
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 33 |
| Phase 2 | 44 |
| Phase 3 | 25 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Rheumatoid Arthritis Trial Landscape
199 indexed Rheumatoid Arthritis studies · 37 recruiting (19%).
Phase mix: 32 late (III/IV) vs 77 early (I/II).
Top sponsor: Zimmer Biomet (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Rheumatoid Arthritis?
PlainTrial tracks 199 US clinical trials for Rheumatoid Arthritis, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Rheumatoid Arthritis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.