Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Rheumatoid Arthritis: early-phase trial registry
37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #50 of 28,707 conditions by registered trial count.
199 US clinical trials · 37 currently recruiting · #50 of 28,707 conditions by registered trial count
Rheumatoid Arthritis: 199 US clinical trials tracked, 37 recruiting.
Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.
Enrollment posture brief
Registry condition rheumatoid-arthritis
OPEN 37 | RECR 19% | LATE 32 | EARLY 77 | RANK #50 | SPON 13
Volume-matched condition peers
Nearest open-share peer: Leukemia (19% recruiting · 274 trials)
Rheumatoid Arthritis lists 37 open slots (19% of 199 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Rheumatoid Arthritis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Rheumatoid Arthritis is recruiting below its size-band peers.
37 of 199 indexed trials (18.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Rheumatoid Arthritis trials is spread across many organizations.
Zimmer Biomet accounts for 13 of 199 trials (6.5%). 114 distinct sponsors appear on at least one study for this condition label.
-
Typical Rheumatoid Arthritis enrolment sits around 154 participants.
Median target enrolment is 154 among the 198 trials that report a genuine target (sentinel values excluded). 78 of those (39.4%) plan for fewer than 100 participants.
-
Rheumatoid Arthritis research is mostly interventional.
154 interventional and 45 observational studies make up this index (77.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
199 total, page 2 of 4
Persona Ti-Nidium Post-Market Clinical Follow-up
Zimmer Biomet
NCT04817969
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
Zimmer Biomet
NCT01480440
Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
Zimmer Biomet
NCT01307384
Database Retrieval for the Comprehensive Shoulder
Zimmer Biomet
NCT03409718
Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
Novartis Pharmaceuticals
NCT06293365
The Immunogenicity and Safety of Zostavax® and Shingrix® in Rheumatoid Arthritis Patients Using Abatacept
Kevin Winthrop
NCT03604406
Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System
Zimmer Biomet
NCT03626038
Zimmer Trabecular Metal Total Ankle PMCF
Zimmer Biomet
NCT02038140
A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis
Immunovant Sciences
NCT06754462
Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity
Brigham and Women's Hospital
NCT05715463
Utilizing MRI for Earlier Diagnosis of Rheumatoid Arthritis
Mayo Clinic
NCT03841279
Study of GS-0272 in Participants With Rheumatoid Arthritis
Gilead Sciences
NCT06031415
A Study of LY3541860 in Adult Participants With Moderately to Severely Active Rheumatoid Arthritis
Eli Lilly and Company
NCT06859294
Discovering the Antecedents of Rheumatoid Arthritis Flare
Rockefeller University
NCT02051114
Long Term Extension of Safety and Efficacy of Vagus Nerve Stimulator in Patients With Rheumatoid Arthritis (RA)
SetPoint Medical Corporation
NCT04862117
A Clinical Study to Assess the Efficacy of Cannabigerol in Patients with Active Rheumatoid Arthritis.
Raphael Pharma
NCT06513507
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs Hydroxychloroquine
Brigham and Women's Hospital
NCT04691505
Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)- Cardiovascular Endpoints
Brigham and Women's Hospital
NCT04772248
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tocilizumab vs Abatacept
Brigham and Women's Hospital
NCT04529863
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept
Brigham and Women's Hospital
NCT04529876
A Study to Understand How Effective is Tofacitinib When Compared to Other Advanced Treatments in Patients With Rheumatoid Arthritis
Pfizer
NCT06418529
Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids
University of Alabama at Birmingham
NCT01378689
Study of Human Anti-TNF Monoclonal Antibody D2E7 in Subjects With Active Rheumatoid Arthritis
Abbott
NCT00049751
Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions: The Corrona CERTAIN Sub-study
CorEvitas
NCT01625650
Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis
R-Pharm International
NCT03120949
Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis
UCB Pharma
NCT00717236
Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement
DePuy Orthopaedics
NCT00306930
A Study of Baricitinib in Participants With Rheumatoid Arthritis
Eli Lilly and Company
NCT04086745
Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF Therapy
Bristol-Myers Squibb
NCT00124982
A Study to Compare Subcutaneous Versus Intravenous Administration of RoActemra/Actemra (Tocilizumab) in Participants With Moderate to Severe Active Rheumatoid Arthritis
Hoffmann-La Roche
NCT01194414
Genetic Registry for Rheumatoid Arthritis
Northwell Health
NCT00069472
Study of Families With Twins or Siblings Discordant for Rheumatic Disorders
National Institute of Environmental Health Sciences (NIEHS)
NCT00055055
Development and Evaluation of A Mailed Arthritis Self-Management Program
University of North Carolina
NCT00448474
Long Term Open Label Continuation Study
Abbott
NCT00195650
Long-term Follow-up Study of GLPG0634 in Active Rheumatoid Arthritis Participants
Galapagos
NCT02065700
A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis
Hoffmann-La Roche
NCT01232569
Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Anti-TNFα Agents
Novartis Pharmaceuticals
NCT01377012
Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis
University of Nebraska
NCT01156155
Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory Arthritis
University of Arizona
NCT00796809
A Study in Participants With Moderate to Severe Rheumatoid Arthritis
Eli Lilly and Company
NCT01711359
Assess Structural Damage in Rheumatoid Arthritis Using Biomarkers and Radiography
Care Arthritis
NCT01476956
A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate Treatment
Hoffmann-La Roche
NCT00810199
Abatacept With Methotrexate- Phase IIB
Bristol-Myers Squibb
NCT00162266
Comparative Analysis of Outcomes Among Patients Initiating Xeljanz in Combination With Oral MTX Who Withdraw MTX Versus Continue MTX
Pfizer
NCT03975790
Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001885
Study of Etanercept Monotherapy vs Methotrexate Monotherapy for Maintenance of Rheumatoid Arthritis Remission
Amgen
NCT02373813
Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH)
Sanofi
NCT02332590
Study to Characterize the Pharmacokinetics of a Single Dose of SC Abatacept 125 mg Using the BD Autoinjector or the Prefilled Syringe
Bristol-Myers Squibb
NCT01890473
Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy
US Department of Veterans Affairs
NCT00405275
A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis
Hoffmann-La Roche
NCT01382940
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 33 |
| Phase 2 | 44 |
| Phase 3 | 25 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Rheumatoid Arthritis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Rheumatoid Arthritis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Rheumatoid Arthritis page
199 registered trials, 37 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 37 Rheumatoid Arthritis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Zimmer Biomet sponsors the most Rheumatoid Arthritis trials on record, review their full trial history before evaluating a specific study. See Zimmer Biomet's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Rheumatoid Arthritis condition card totals 199 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.