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NCT00055055 · ClinicalTrials.gov registry record
Study of Families With Twins or Siblings Discordant for Rheumatic Disorders
A clinical trial of Rheumatoid Arthritis and Systemic Lupus Erythematosus, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- Completed
- Registry status
- 1,056
- Enrollment target
- 3
- Study locations
NCT00055055: Completed study of Rheumatoid Arthritis and Systemic Lupus Erythematosus, sponsored by National Institute of Environmental Health Sciences (NIEHS).
NCT00055055 is a study of Rheumatoid Arthritis and Systemic Lupus Erythematosus that has completed, run by National Institute of Environmental Health Sciences (NIEHS). The registered enrollment target is 1,056 participants, below the 4,685-participant average among 197 other Rheumatoid Arthritis trials with a reported enrollment target (77% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00055055, a study of Rheumatoid Arthritis and Systemic Lupus Erythematosus, has completed, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- COMPLETED
- Registry status
- 1,056 participants
- Enrollment target
- 3
- Study locations
Study Summary
This study will examine families in which one sibling of a sibling pair, or twin pair, has developed a systemic rheumatic disease and one has not, to see if and how the two differ in the following: * Blood cell metabolism; * Types of cells in the blood; * Environmental exposures or genetic factors that might explain why one developed disease and the other did not. Families in which one sibling has developed a systemic rheumatic disease, rheumatoid arthritis, systemic lupus erythematosus, scleroderma, dermatomyositis, or myositis, and the other has not, are eligible for this study. The siblings may or may not be twins, but must be of the same gender and be within a 5-year age difference. Biological parents, or, in some cases, children, will also be included in the study. Normal, healthy volunteers will serve as control subjects. Participants will undergo some or all of the following tests and procedures: * Medical history and physical examination. Participants will also be asked permission to obtain medical records for review. * Questionnaires about environmental exposures at work, at home, and elsewhere. Probands (participants with rheumatic disease) and their healthy siblings will also answer questions about infections, vaccinations, medications or dietary supplements, sun exposure, and stressful events during the year before disease diagnosis in the affected sibling. * Blood and urine collection for the following tests: * Routine blood chemistries and other studies to rule out certain diseases or medical problems; * Evidence of past toxic exposures and certain infections; * Presence of cells from the mother in the child s blood and vice versa. (Recent studies suggest that during pregnancy or delivery, cells from the mother and baby may be exchanged and circulate in the body for many years, possibly causing problems); * In twin or sibling pairs, presence of certain genes that may be more common in patients with systematic rheumatic diseases as compared with the
Primary Outcome
Evaluate core set disease activity, damage and quality of life measures in adult and juvenile myositis patients
Conditions Studied
Study Locations (3)
Maryland
- National Institutes of Health Clinical Center - Bethesda
North Carolina
- NIEHS Clinical Research Unit (CRU) - Research Triangle Park
Wisconsin
- University of Wisconsin - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,056 participants |
| Start Date | 2003-04-21 |
What the finished NCT00055055 record still lists
NCT00055055 is an observational study that tracks outcomes without assigning an intervention. Its 1,056 participants enrollment target places it among the larger protocols in the corpus, below the 4,685-participant average among 197 other Rheumatoid Arthritis trials with a reported enrollment target (77% lower).
The record links to 3 conditions, with Rheumatoid Arthritis appearing as the primary indexed condition, and to 0 interventions.
NCT00055055 reports a single indexed study location in Maryland, North Carolina, Wisconsin.
Frequently Asked Questions
What is clinical trial NCT00055055 about?
NCT00055055 is a clinical study titled "Study of Families With Twins or Siblings Discordant for Rheumatic Disorders". This study will examine families in which one sibling of a sibling pair, or twin pair, has developed a systemic rheumatic disease and one has not, to see if and how the two differ in the following: * Blood cell metabolism; * Types of cells in the blood; * Environmental exposures or genetic factors ...
What is the current status of trial NCT00055055?
This trial is currently completed. The enrollment target is 1,056 participants. The study started on 2003-04-21.
What conditions does trial NCT00055055 study?
This clinical trial studies the following conditions: Rheumatoid Arthritis, Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies.
Who is sponsoring clinical trial NCT00055055?
This trial is sponsored by National Institute of Environmental Health Sciences (NIEHS), which has 145 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00055055 being conducted?
This trial has 3 study locations across Maryland, North Carolina, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00055055's enrollment target sits among peer trials
1,056 22nd of 197 higher than 176 of 197 other Rheumatoid Arthritis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Rheumatoid Arthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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