Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Overweight

Open-data reference.

198 US clinical trials · 50 currently recruiting

Active & Recent Trials

RECRUITING 100,000 participants

International Weight Control Registry

Tufts University

NCT04907396

RECRUITING Phase 3 12,800 participants

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Amgen

NCT07037433

RECRUITING 5,000 participants

Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study

Duke University

NCT06595251

RECRUITING Phase 3 1,980 participants

A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

Eli Lilly and Company

NCT07321886

RECRUITING Phase 3 1,800 participants

Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

Kailera

NCT07284875

RECRUITING Phase 2 1,785 participants

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

Memorial Sloan Kettering Cancer Center

NCT05770570

RECRUITING Phase 2 1,217 participants

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Eli Lilly and Company

NCT06143956

RECRUITING Phase 3 1,200 participants

A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes

Eli Lilly and Company

NCT06993792

RECRUITING Phase 3 1,035 participants

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

Eli Lilly and Company

NCT07282600

RECRUITING 1,000 participants

Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study

Duke University

NCT06604650

RECRUITING Phase 3 900 participants

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

Eli Lilly and Company

NCT07392190

RECRUITING Phase 3 800 participants

A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight

Eli Lilly and Company

NCT07369011

RECRUITING Phase 3 600 participants

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity

Eli Lilly and Company

NCT06972459

RECRUITING Phase 3 600 participants

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes

Eli Lilly and Company

NCT06972472

RECRUITING Phase 3 600 participants

A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight

Eli Lilly and Company

NCT07357415

RECRUITING Phase 3 586 participants

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Eli Lilly and Company

NCT07035093

RECRUITING NA 503 participants

Avoid and Resist Strategies for Weight Management

Cedars-Sinai Medical Center

NCT05143931

RECRUITING Phase 3 460 participants

A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

Novo Nordisk A/S

NCT07253285

RECRUITING NA 454 participants

Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial

University of Pittsburgh

NCT05655936

RECRUITING Phase 2 333 participants

A Research Study on How Well Different Doses of the Medicine UBT251 Help People Living With Overweight or Obesity

Novo Nordisk A/S

NCT07395687

RECRUITING NA 320 participants

HealthyTogether: RCT of a Dyadic Weight Management Intervention

VA Office of Research and Development

NCT06619041

RECRUITING Phase 3 250 participants

A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight

Eli Lilly and Company

NCT07232719

RECRUITING Phase 2 220 participants

A Research Study on How Well Different Doses of the Medicine NNC0662-0419 Help People Living With Overweight or Obesity

Novo Nordisk A/S

NCT07184632

RECRUITING Phase 1 201 participants

A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes

Eli Lilly and Company

NCT06945419

RECRUITING Phase 2 200 participants

A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Eli Lilly and Company

NCT07215559

RECRUITING Phase 2 197 participants

Semaglutide for Post-Smoking Cessation Weight Management

The University of Texas Health Science Center, Houston

NCT06173778

RECRUITING NA 184 participants

Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients

Nitinotes Surgical

NCT07090005

RECRUITING NA 180 participants

Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

Salk Institute for Biological Studies

NCT06891352

RECRUITING Phase 1 177 participants

A Study on How NNC0174-1213 Works in People With Overweight or Obesity.

Novo Nordisk A/S

NCT06719011

RECRUITING Phase 2 150 participants

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT03407079

RECRUITING Phase 3 125 participants

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

Eli Lilly and Company

NCT06672549

RECRUITING Phase 3 125 participants

A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities

Eli Lilly and Company

NCT06672939

RECRUITING Phase 1 120 participants

A Study of LY3549492 in Healthy Participants and Participants With Overweight or Obesity

Eli Lilly and Company

NCT07232732

RECRUITING NA 100 participants

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT06044935

RECRUITING Phase 1 96 participants

A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity

Novo Nordisk A/S

NCT07437079

RECRUITING NA 90 participants

Time Restricted Feeding, Muscle, and Metabolism

University of Arkansas, Fayetteville

NCT04949451

RECRUITING Phase 1 84 participants

A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Eli Lilly and Company

NCT07225556

RECRUITING NA 80 participants

Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure

Georgia State University

NCT06735599

RECRUITING NA 70 participants

Night Owl Metabolism

Johns Hopkins University

NCT06507722

RECRUITING Phase 2 66 participants

Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity

Stanford University

NCT05912621

RECRUITING Phase 1 60 participants

A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults

Shanghai World Leader Pharmaceutical Co.

NCT07465965

RECRUITING NA 60 participants

Improving Glycemic Control With Electrical Stimulation

University of Texas, El Paso

NCT03947697

RECRUITING NA 60 participants

In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes

Cornell University

NCT06557317

RECRUITING Phase 1 54 participants

A Study to Learn How the Study Medicine Called PF-08653944 is Taken up Into the Blood in Adults With Overweight or Obesity.

Pfizer

NCT07400679

RECRUITING NA 50 participants

Nutrition and Exercise Interventions in Reducing Androgen Deprivation Therapy-Induced Obese Frailty in Prostate Cancer Survivors

Roswell Park Cancer Institute

NCT03880422

RECRUITING NA 42 participants

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT06325722

RECRUITING NA 30 participants

Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

Georgia State University

NCT06735651

RECRUITING 20 participants

Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

Massachusetts General Hospital

NCT05799222

RECRUITING NA 20 participants

The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

University of California, Davis

NCT04248127

RECRUITING NA 16 participants

Dietary Supplementation on Fat Oxidation

Brightseed

NCT06548048

ACTIVE NOT RECRUITING 60,000 participants

INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)

Brigham and Women's Hospital

NCT07417618

ACTIVE NOT RECRUITING Phase 3 15,374 participants

A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Eli Lilly and Company

NCT05556512

ACTIVE NOT RECRUITING NA 5,000 participants

Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0

Brigham and Women's Hospital

NCT05553925

ACTIVE NOT RECRUITING Phase 3 3,127 participants

A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

Eli Lilly and Company

NCT05869903

ACTIVE NOT RECRUITING Phase 3 2,749 participants

A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Eli Lilly and Company

NCT05803421

ACTIVE NOT RECRUITING Phase 3 2,300 participants

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight

Eli Lilly and Company

NCT05929066

ACTIVE NOT RECRUITING Phase 3 1,000 participants

A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

Eli Lilly and Company

NCT05929079

ACTIVE NOT RECRUITING Phase 3 905 participants

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company

NCT06914895

ACTIVE NOT RECRUITING 500 participants

Biological Sample Repository for Gastrointestinal Disorders

Pichamol Jirapinyo, MD, MPH

NCT05874726

ACTIVE NOT RECRUITING Phase 3 465 participants

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company

NCT06962280

ACTIVE NOT RECRUITING NA 440 participants

TOTAL: A Multisite RCT

VA Office of Research and Development

NCT05346575

ACTIVE NOT RECRUITING Phase 3 400 participants

A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Eli Lilly and Company

NCT06047548

ACTIVE NOT RECRUITING Phase 2 350 participants

A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes

Eli Lilly and Company

NCT06603571

ACTIVE NOT RECRUITING Phase 1 348 participants

Comparing the Extent to Which Maridebart Cafraglutide (AMG 133) is Made Available in the Body When Administered Using Two Subcutaneous (SC) Presentations

Amgen

NCT07226778

ACTIVE NOT RECRUITING Phase 3 330 participants

Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide

Novo Nordisk A/S

NCT07220759

ACTIVE NOT RECRUITING Phase 1 302 participants

A Study of LY3537031 in Overweight, Obese, and Healthy Participants

Eli Lilly and Company

NCT06606106

ACTIVE NOT RECRUITING NA 300 participants

NYUCI-ES: Psychosocial Intervention to Improve Health Outcomes for Chinese and Korean ADRD Caregivers

New York University

NCT05461495

ACTIVE NOT RECRUITING Phase 3 300 participants

Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide

Novo Nordisk A/S

NCT07220642

ACTIVE NOT RECRUITING Phase 2 288 participants

A Study to Investigate Weight Management With LY3549492 Compared With Placebo in Adult Participants With Obesity or Overweight

Eli Lilly and Company

NCT06683508

ACTIVE NOT RECRUITING Phase 2 285 participants

A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity

Hoffmann-La Roche

NCT06965413

ACTIVE NOT RECRUITING Phase 2 240 participants

A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight

Eli Lilly and Company

NCT06643728

ACTIVE NOT RECRUITING Phase 4 226 participants

A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)

WW International

NCT06605703

ACTIVE NOT RECRUITING Phase 2 221 participants

Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2)

Zealand Pharma

NCT06926842

ACTIVE NOT RECRUITING Phase 2 206 participants

A Study of Weekly Oral Ecnoglutide (VRB-101) in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Verdiva Bio Dev Limited

NCT07281937

ACTIVE NOT RECRUITING NA 175 participants

Promotion of Weight Management

VA Office of Research and Development

NCT04131647

ACTIVE NOT RECRUITING Phase 3 150 participants

A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Eli Lilly and Company

NCT06075667

ACTIVE NOT RECRUITING Phase 2 150 participants

Taldefgrobep Alfa in Adults With Overweight and Obesity

Biohaven Therapeutics

NCT07281495

ACTIVE NOT RECRUITING Phase 2 140 participants

A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Eli Lilly and Company

NCT05536804

ACTIVE NOT RECRUITING NA 100 participants

A Study of Time Restricted Eating in Obese Adults

Mayo Clinic

NCT05660291

ACTIVE NOT RECRUITING Phase 2 82 participants

A Dose-Range Study of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

NCT06703021

ACTIVE NOT RECRUITING Phase 1 81 participants

Effect of Maridebart Cafraglutide on the Heart's Electrical Activity

Amgen

NCT07229157

ACTIVE NOT RECRUITING Phase 2 80 participants

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

Massachusetts General Hospital

NCT05774665

ACTIVE NOT RECRUITING NA 68 participants

Piloting a Patient Navigator Program for Weight Loss

Drexel University

NCT06972381

ACTIVE NOT RECRUITING Phase 1 63 participants

A Research Study on How NNC0638-0355, a New Medicine, Works in People Living With Overweight or Obesity

Novo Nordisk A/S

NCT06577766

ACTIVE NOT RECRUITING NA 60 participants

Study to Evaluate the Efficacy of an Avocado Dietary Supplement

SP Nutraceuticals

NCT07354308

ACTIVE NOT RECRUITING NA 51 participants

Diabetes Prevention Program With or Without Hunger Training in Helping to Lower Breast Cancer Risk in Obese Participants

M.D. Anderson Cancer Center

NCT03546972

ACTIVE NOT RECRUITING NA 50 participants

The Effects of Almond Consumption on Functional Performance and Activity in Overweight Active Older Adults

Florida State University

NCT04778371

ACTIVE NOT RECRUITING 50 participants

Variety of Physical Activity in Normal to Overweight Adults Who Are Regularly Active

The University of Tennessee, Knoxville

NCT02149147

ACTIVE NOT RECRUITING NA 44 participants

Olive Oil Polyphenols and Cardiovascular Health Biomarkers

University of California, Davis

NCT04149288

ACTIVE NOT RECRUITING NA 40 participants

Impact of Metabolic Health on Sperm Epigenetic Marks in Humans

Joslin Diabetes Center

NCT03860558

ACTIVE NOT RECRUITING NA 40 participants

Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes

Brigham and Women's Hospital

NCT05560971

ACTIVE NOT RECRUITING 36 participants

Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL)

AdventHealth Translational Research Institute

NCT01745471

ACTIVE NOT RECRUITING NA 25 participants

Study of the Carbon Dioxide Treatment for Fat Reduction

Northwestern University

NCT00974415

ACTIVE NOT RECRUITING NA 20 participants

Family-Based Treatment for Type 1 Diabetes

State University of New York at Buffalo

NCT05756361

ACTIVE NOT RECRUITING NA 20 participants

Enhancing Mental and Physical Health of Women Veterans

VA Office of Research and Development

NCT05050266

COMPLETED NA 3,765 participants

Mass in Motion Kids in the Clinical Setting

Massachusetts General Hospital

NCT02110615

COMPLETED 3,439 participants

SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial

Novo Nordisk A/S

NCT04972721

COMPLETED NA 2,600 participants

Electronic Tools to Assist With Identification of and Counseling for Overweight Patients

Northwestern University

NCT00973661

COMPLETED Phase 3 1,613 participants

A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes

Eli Lilly and Company

NCT05872620

COMPLETED Phase 3 1,210 participants

Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity

Novo Nordisk A/S

NCT03552757

Phase Distribution

PhaseTrial count
Early Phase 1 21
Phase 2 25
Phase 3 36
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Overweight Trial Landscape

ClinicalTrials.gov lists 198 US studies indexed under Overweight, and 50 of those are currently open to recruitment — roughly 25% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Overweight shows 37 late-stage studies (Phase 3 and Phase 4 combined) alongside 46 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Overweight is led by Eli Lilly and Company with 37 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Overweight?

PlainTrial tracks 198 US clinical trials for Overweight, of which 50 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Overweight?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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