Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Overweight
Open-data reference.
198 US clinical trials · 50 currently recruiting
Active & Recent Trials
International Weight Control Registry
Tufts University
NCT04907396
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Amgen
NCT07037433
Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study
Duke University
NCT06595251
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
Eli Lilly and Company
NCT07321886
Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
Kailera
NCT07284875
Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)
Memorial Sloan Kettering Cancer Center
NCT05770570
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
Eli Lilly and Company
NCT06143956
A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
Eli Lilly and Company
NCT06993792
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
Eli Lilly and Company
NCT07282600
Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study
Duke University
NCT06604650
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
Eli Lilly and Company
NCT07392190
A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight
Eli Lilly and Company
NCT07369011
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity
Eli Lilly and Company
NCT06972459
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
Eli Lilly and Company
NCT06972472
A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight
Eli Lilly and Company
NCT07357415
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
Eli Lilly and Company
NCT07035093
Avoid and Resist Strategies for Weight Management
Cedars-Sinai Medical Center
NCT05143931
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
Novo Nordisk A/S
NCT07253285
Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial
University of Pittsburgh
NCT05655936
A Research Study on How Well Different Doses of the Medicine UBT251 Help People Living With Overweight or Obesity
Novo Nordisk A/S
NCT07395687
HealthyTogether: RCT of a Dyadic Weight Management Intervention
VA Office of Research and Development
NCT06619041
A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
Eli Lilly and Company
NCT07232719
A Research Study on How Well Different Doses of the Medicine NNC0662-0419 Help People Living With Overweight or Obesity
Novo Nordisk A/S
NCT07184632
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
Eli Lilly and Company
NCT06945419
A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes
Eli Lilly and Company
NCT07215559
Semaglutide for Post-Smoking Cessation Weight Management
The University of Texas Health Science Center, Houston
NCT06173778
Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients
Nitinotes Surgical
NCT07090005
Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers
Salk Institute for Biological Studies
NCT06891352
A Study on How NNC0174-1213 Works in People With Overweight or Obesity.
Novo Nordisk A/S
NCT06719011
Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT03407079
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
Eli Lilly and Company
NCT06672549
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Eli Lilly and Company
NCT06672939
A Study of LY3549492 in Healthy Participants and Participants With Overweight or Obesity
Eli Lilly and Company
NCT07232732
Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06044935
A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity
Novo Nordisk A/S
NCT07437079
Time Restricted Feeding, Muscle, and Metabolism
University of Arkansas, Fayetteville
NCT04949451
A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy
Eli Lilly and Company
NCT07225556
Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure
Georgia State University
NCT06735599
Night Owl Metabolism
Johns Hopkins University
NCT06507722
Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity
Stanford University
NCT05912621
A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults
Shanghai World Leader Pharmaceutical Co.
NCT07465965
Improving Glycemic Control With Electrical Stimulation
University of Texas, El Paso
NCT03947697
In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes
Cornell University
NCT06557317
A Study to Learn How the Study Medicine Called PF-08653944 is Taken up Into the Blood in Adults With Overweight or Obesity.
Pfizer
NCT07400679
Nutrition and Exercise Interventions in Reducing Androgen Deprivation Therapy-Induced Obese Frailty in Prostate Cancer Survivors
Roswell Park Cancer Institute
NCT03880422
Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06325722
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
Georgia State University
NCT06735651
Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population
Massachusetts General Hospital
NCT05799222
The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.
University of California, Davis
NCT04248127
Dietary Supplementation on Fat Oxidation
Brightseed
NCT06548048
INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)
Brigham and Women's Hospital
NCT07417618
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
Eli Lilly and Company
NCT05556512
Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0
Brigham and Women's Hospital
NCT05553925
A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
Eli Lilly and Company
NCT05869903
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
Eli Lilly and Company
NCT05803421
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
Eli Lilly and Company
NCT05929066
A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
Eli Lilly and Company
NCT05929079
A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
Eli Lilly and Company
NCT06914895
Biological Sample Repository for Gastrointestinal Disorders
Pichamol Jirapinyo, MD, MPH
NCT05874726
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
Eli Lilly and Company
NCT06962280
TOTAL: A Multisite RCT
VA Office of Research and Development
NCT05346575
A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
Eli Lilly and Company
NCT06047548
A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes
Eli Lilly and Company
NCT06603571
Comparing the Extent to Which Maridebart Cafraglutide (AMG 133) is Made Available in the Body When Administered Using Two Subcutaneous (SC) Presentations
Amgen
NCT07226778
Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
Novo Nordisk A/S
NCT07220759
A Study of LY3537031 in Overweight, Obese, and Healthy Participants
Eli Lilly and Company
NCT06606106
NYUCI-ES: Psychosocial Intervention to Improve Health Outcomes for Chinese and Korean ADRD Caregivers
New York University
NCT05461495
Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide
Novo Nordisk A/S
NCT07220642
A Study to Investigate Weight Management With LY3549492 Compared With Placebo in Adult Participants With Obesity or Overweight
Eli Lilly and Company
NCT06683508
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
Hoffmann-La Roche
NCT06965413
A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight
Eli Lilly and Company
NCT06643728
A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)
WW International
NCT06605703
Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2)
Zealand Pharma
NCT06926842
A Study of Weekly Oral Ecnoglutide (VRB-101) in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
Verdiva Bio Dev Limited
NCT07281937
Promotion of Weight Management
VA Office of Research and Development
NCT04131647
A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
Eli Lilly and Company
NCT06075667
Taldefgrobep Alfa in Adults With Overweight and Obesity
Biohaven Therapeutics
NCT07281495
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
Eli Lilly and Company
NCT05536804
A Study of Time Restricted Eating in Obese Adults
Mayo Clinic
NCT05660291
A Dose-Range Study of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
NCT06703021
Effect of Maridebart Cafraglutide on the Heart's Electrical Activity
Amgen
NCT07229157
Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression
Massachusetts General Hospital
NCT05774665
Piloting a Patient Navigator Program for Weight Loss
Drexel University
NCT06972381
A Research Study on How NNC0638-0355, a New Medicine, Works in People Living With Overweight or Obesity
Novo Nordisk A/S
NCT06577766
Study to Evaluate the Efficacy of an Avocado Dietary Supplement
SP Nutraceuticals
NCT07354308
Diabetes Prevention Program With or Without Hunger Training in Helping to Lower Breast Cancer Risk in Obese Participants
M.D. Anderson Cancer Center
NCT03546972
The Effects of Almond Consumption on Functional Performance and Activity in Overweight Active Older Adults
Florida State University
NCT04778371
Variety of Physical Activity in Normal to Overweight Adults Who Are Regularly Active
The University of Tennessee, Knoxville
NCT02149147
Olive Oil Polyphenols and Cardiovascular Health Biomarkers
University of California, Davis
NCT04149288
Impact of Metabolic Health on Sperm Epigenetic Marks in Humans
Joslin Diabetes Center
NCT03860558
Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
Brigham and Women's Hospital
NCT05560971
Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL)
AdventHealth Translational Research Institute
NCT01745471
Study of the Carbon Dioxide Treatment for Fat Reduction
Northwestern University
NCT00974415
Family-Based Treatment for Type 1 Diabetes
State University of New York at Buffalo
NCT05756361
Enhancing Mental and Physical Health of Women Veterans
VA Office of Research and Development
NCT05050266
Mass in Motion Kids in the Clinical Setting
Massachusetts General Hospital
NCT02110615
SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial
Novo Nordisk A/S
NCT04972721
Electronic Tools to Assist With Identification of and Counseling for Overweight Patients
Northwestern University
NCT00973661
A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes
Eli Lilly and Company
NCT05872620
Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity
Novo Nordisk A/S
NCT03552757
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 21 |
| Phase 2 | 25 |
| Phase 3 | 36 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Overweight Trial Landscape
ClinicalTrials.gov lists 198 US studies indexed under Overweight, and 50 of those are currently open to recruitment — roughly 25% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Overweight shows 37 late-stage studies (Phase 3 and Phase 4 combined) alongside 46 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Overweight is led by Eli Lilly and Company with 37 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Overweight?
PlainTrial tracks 198 US clinical trials for Overweight, of which 50 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Overweight?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.