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ClinicalTrials.gov 50 recruiting now official registry

Overweight clinical trials

50 of 198 indexed Overweight trials are currently recruiting.

198 US clinical trials · 50 currently recruiting

Overweight is the subject of 198 registered US clinical trials on ClinicalTrials.gov, 50 of them currently open to new participants. 37 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 37 of these trials.

The research picture

Overweight has 198 registered US clinical trials, 50 of them open to new participants right now, about 25% of the total.

50
recruiting participants now
25%
of trials open to enrollment
37
in Phase 3–4 (later-stage)
37
top sponsor: Eli Lilly and Company
Phase 121Phase 225Phase 336Phase 41

Active & Recent Trials

198 total, page 1 of 4

RECRUITING 100,000 participants

International Weight Control Registry

Tufts University

NCT04907396

RECRUITING Phase 3 12,800 participants

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Amgen

NCT07037433

RECRUITING 5,000 participants

Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study

Duke University

NCT06595251

RECRUITING Phase 3 1,980 participants

A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

Eli Lilly and Company

NCT07321886

RECRUITING Phase 3 1,800 participants

Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

Kailera

NCT07284875

RECRUITING Phase 2 1,785 participants

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

Memorial Sloan Kettering Cancer Center

NCT05770570

RECRUITING Phase 2 1,217 participants

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Eli Lilly and Company

NCT06143956

RECRUITING Phase 3 1,200 participants

A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes

Eli Lilly and Company

NCT06993792

RECRUITING Phase 3 1,035 participants

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

Eli Lilly and Company

NCT07282600

RECRUITING 1,000 participants

Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study

Duke University

NCT06604650

RECRUITING Phase 3 900 participants

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

Eli Lilly and Company

NCT07392190

RECRUITING Phase 3 800 participants

A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight

Eli Lilly and Company

NCT07369011

RECRUITING Phase 3 600 participants

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity

Eli Lilly and Company

NCT06972459

RECRUITING Phase 3 600 participants

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes

Eli Lilly and Company

NCT06972472

RECRUITING Phase 3 600 participants

A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight

Eli Lilly and Company

NCT07357415

RECRUITING Phase 3 586 participants

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Eli Lilly and Company

NCT07035093

RECRUITING NA 503 participants

Avoid and Resist Strategies for Weight Management

Cedars-Sinai Medical Center

NCT05143931

RECRUITING Phase 3 460 participants

A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

Novo Nordisk A/S

NCT07253285

RECRUITING NA 454 participants

Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial

University of Pittsburgh

NCT05655936

RECRUITING Phase 2 333 participants

A Research Study on How Well Different Doses of the Medicine UBT251 Help People Living With Overweight or Obesity

Novo Nordisk A/S

NCT07395687

RECRUITING NA 320 participants

HealthyTogether: RCT of a Dyadic Weight Management Intervention

VA Office of Research and Development

NCT06619041

RECRUITING Phase 3 250 participants

A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight

Eli Lilly and Company

NCT07232719

RECRUITING Phase 2 220 participants

A Research Study on How Well Different Doses of the Medicine NNC0662-0419 Help People Living With Overweight or Obesity

Novo Nordisk A/S

NCT07184632

RECRUITING Phase 1 201 participants

A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes

Eli Lilly and Company

NCT06945419

RECRUITING Phase 2 200 participants

A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Eli Lilly and Company

NCT07215559

RECRUITING Phase 2 197 participants

Semaglutide for Post-Smoking Cessation Weight Management

The University of Texas Health Science Center, Houston

NCT06173778

RECRUITING NA 184 participants

Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients

Nitinotes Surgical

NCT07090005

RECRUITING NA 180 participants

Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

Salk Institute for Biological Studies

NCT06891352

RECRUITING Phase 1 177 participants

A Study on How NNC0174-1213 Works in People With Overweight or Obesity.

Novo Nordisk A/S

NCT06719011

RECRUITING Phase 2 150 participants

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NCT03407079

RECRUITING Phase 3 125 participants

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

Eli Lilly and Company

NCT06672549

RECRUITING Phase 3 125 participants

A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities

Eli Lilly and Company

NCT06672939

RECRUITING Phase 1 120 participants

A Study of LY3549492 in Healthy Participants and Participants With Overweight or Obesity

Eli Lilly and Company

NCT07232732

RECRUITING NA 100 participants

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT06044935

RECRUITING Phase 1 96 participants

A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity

Novo Nordisk A/S

NCT07437079

RECRUITING NA 90 participants

Time Restricted Feeding, Muscle, and Metabolism

University of Arkansas, Fayetteville

NCT04949451

RECRUITING Phase 1 84 participants

A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Eli Lilly and Company

NCT07225556

RECRUITING NA 80 participants

Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure

Georgia State University

NCT06735599

RECRUITING NA 70 participants

Night Owl Metabolism

Johns Hopkins University

NCT06507722

RECRUITING Phase 2 66 participants

Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity

Stanford University

NCT05912621

RECRUITING Phase 1 60 participants

A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults

Shanghai World Leader Pharmaceutical Co.

NCT07465965

RECRUITING NA 60 participants

Improving Glycemic Control With Electrical Stimulation

University of Texas, El Paso

NCT03947697

RECRUITING NA 60 participants

In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes

Cornell University

NCT06557317

RECRUITING Phase 1 54 participants

A Study to Learn How the Study Medicine Called PF-08653944 is Taken up Into the Blood in Adults With Overweight or Obesity.

Pfizer

NCT07400679

RECRUITING NA 50 participants

Nutrition and Exercise Interventions in Reducing Androgen Deprivation Therapy-Induced Obese Frailty in Prostate Cancer Survivors

Roswell Park Cancer Institute

NCT03880422

RECRUITING NA 42 participants

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT06325722

RECRUITING NA 30 participants

Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

Georgia State University

NCT06735651

RECRUITING 20 participants

Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

Massachusetts General Hospital

NCT05799222

RECRUITING NA 20 participants

The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

University of California, Davis

NCT04248127

RECRUITING NA 16 participants

Dietary Supplementation on Fat Oxidation

Brightseed

NCT06548048

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Phase Distribution

PhaseTrial count
Phase 1 21
Phase 2 25
Phase 3 36
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Overweight Trial Landscape

198 indexed Overweight studies · 50 recruiting (25%).

Phase mix: 37 late (III/IV) vs 46 early (I/II).

Top sponsor: Eli Lilly and Company (37 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Overweight?

PlainTrial tracks 198 US clinical trials for Overweight, of which 50 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Overweight?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.