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Rheumatoid Arthritis: early-phase trial registry
37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #50 of 28,707 conditions by registered trial count.
199 US clinical trials · 37 currently recruiting · #50 of 28,707 conditions by registered trial count
Rheumatoid Arthritis: 199 US clinical trials tracked, 37 recruiting.
Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.
Enrollment posture brief
Registry condition rheumatoid-arthritis
OPEN 37 | RECR 19% | LATE 32 | EARLY 77 | RANK #50 | SPON 13
Volume-matched condition peers
Nearest open-share peer: Leukemia (19% recruiting · 274 trials)
Rheumatoid Arthritis lists 37 open slots (19% of 199 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Rheumatoid Arthritis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Rheumatoid Arthritis is recruiting below its size-band peers.
37 of 199 indexed trials (18.6%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Rheumatoid Arthritis trials is spread across many organizations.
Zimmer Biomet accounts for 13 of 199 trials (6.5%). 114 distinct sponsors appear on at least one study for this condition label.
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Typical Rheumatoid Arthritis enrolment sits around 154 participants.
Median target enrolment is 154 among the 198 trials that report a genuine target (sentinel values excluded). 78 of those (39.4%) plan for fewer than 100 participants.
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Rheumatoid Arthritis research is mostly interventional.
154 interventional and 45 observational studies make up this index (77.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
199 total, page 3 of 4
Study to Assess the Safety and Efficacy of Modified-Release Prednisone (Lodotra®) Therapy in Patients With Active Rheumatoid Arthritis
Amgen
NCT00650078
Effects of MEDI-522 On Disease Activity and Progression of Joint Damage in Patients With Active Rheumatoid Arthritis Suboptimally Responding to Methotrexate
MedImmune
NCT00069017
Enhancing Patient Ability to Understand and Utilize Complex Information Concerning Medication Self-management
University of North Carolina, Chapel Hill
NCT02820038
Pain and Stress Management for People With Rheumatoid Arthritis
Wayne State University
NCT00088764
GIOP Prevention Among People With Rheumatoid Arthritis
University of North Carolina, Chapel Hill
NCT00609830
Safety and Efficacy of Pf-06650833 In Subjects With Rheumatoid Arthritis, With An Inadequate Response To Methotrexate
Pfizer
NCT02996500
Actis Total Hip System 2 Year Follow-up
DePuy Orthopaedics
NCT02783274
Study of the Effect of Fostamatinib Twice Daily on Blood Pressure in Patients With Rheumatoid Arthritis
AstraZeneca
NCT01563978
The Value of Orencia in Rapidly Progressing Rheumatoid Arthritis
Bristol-Myers Squibb
NCT03331393
Study to Evaluate Efficacy, Safety and Tolerability of JTE-051 in Subjects With Active Rheumatoid Arthritis
Akros Pharma
NCT02919475
Oral CF101 and Methotrexate Treatment in Rheumatoid Arthritis Patients
Can-Fite BioPharma
NCT00280917
A Phase IIb Study for ALX-0061 Monotherapy in Subjects With Rheumatoid Arthritis
Ablynx, a Sanofi company
NCT02287922
A Multicentre Trial to Determine the Efficacy of AD 452 in RA Subjects.
Sosei
NCT00141934
Post-PMA Approval Study: 10 Year Follow-Up IDE Subjects
Corin
NCT00721994
Pharmacokinetic Study to Compare the Blood Levels of Abatacept Manufactured at Lonza Biologics to the Blood Levels of Abatacept Manufactured at the Devens, Massachusetts (MA) Facility of Bristol-Myers Squibb
Bristol-Myers Squibb
NCT01439204
Efficacy and Safety of CDP6038 in Patients With Rheumatoid Arthritis With an Unsuccessful Response to Anti-Tumor Necrosis Factor (Anti-TNF) Therapy
UCB Pharma
NCT01242488
Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System
DePuy Orthopaedics
NCT00487565
A Study of P38 Inhibitor (4) Monotherapy in Patients With Active Rheumatoid Arthritis
Hoffmann-La Roche
NCT00303563
Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology
Brigham and Women's Hospital
NCT05116163
Treatment Efficacy and Toxicity in Rheumatoid Arthritis Database and Repository
University of Alabama at Birmingham
NCT01070121
RAHelp.Org: An Online Self Management Program for Adults With Rheumatoid Arthritis
University of Missouri-Columbia
NCT00283855
Treatment of Arthritis With Syk Kinase Inhibition (TASKI-1)
Rigel Pharmaceuticals
NCT00326339
ROSA Robot Used in Total Knee Replacement Post Market Study
Zimmer Biomet
NCT03969654
Perioperative Flare in RA: Characterization of Clinical and Biological Features
Hospital for Special Surgery, New York
NCT02111057
NexGen TM Tibia Clinical Outcomes Study
Zimmer Biomet
NCT03272373
Treating Rheumatoid Arthritis With Tripterygium Wilfordi Hook F or Sulfasalazine
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00062465
A Clinical Investigation of ArComXL® Polyethylene in Total Hip Replacement
Zimmer Biomet
NCT00698152
Protocol For The Quantitation Of Pain In The Diagnosis Of Polymyalgia Rheumatica
Lahey Clinic
NCT00847236
The Study of Abatacept in Combination With Etanercept
Bristol-Myers Squibb
NCT00162279
Impact of Literacy Level on Patient Education and Health Among People With Arthritis
Brigham and Women's Hospital
NCT00023205
INCB028050 Compared to Background Therapy in Patients With Active Rheumatoid Arthritis (RA) With Inadequate Response to Disease Modifying Anti-Rheumatic Drugs
Incyte Corporation
NCT00902486
"Learning About Biologics"-Rheumatoid Arthritis
Geisinger Clinic
NCT01721200
Basket Study (CT-100-002) to Evaluate the Effects of a DiNaMo™ Component Training
Click Therapeutics
NCT05573685
Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis
Bristol-Myers Squibb
NCT04186871
A Study to Assess Immune Response Following Zoster Vaccination to Subjects With Rheumatoid Arthritis Receiving Tofacitinib or Placebo With Background Methotrexate
Pfizer
NCT02147587
2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use
Encore Medical, L.P.
NCT01284283
A Phase 2 Study to Evaluate the Efficacy and Safety of 60mg of MM-093 in Patients With Active Rheumatoid Arthritis
Merrimack Pharmaceuticals
NCT00458146
Robotic Arm Assisted Total Knee Arthroplasty
MAKO Surgical
NCT02058069
Study in Rheumatoid Arthritis for Subjects Who Completed Preceding Study M13-390 With Adalimumab
AbbVie (prior sponsor, Abbott)
NCT01752855
Vaccination Study of Abatacept (BMS-188667) for Normal Healthy Volunteers
Bristol-Myers Squibb
NCT00279734
Living Well With Rheumatoid Arthritis
Brigham and Women's Hospital
NCT00869349
Safety and Efficacy of Intravenous ACZ885 and Oral Methotrexate Therapy in Patients With Early Rheumatoid Arthritis
Novartis
NCT00487825
Ankle Joint Replacement Outcomes Study
Smith & Nephew
NCT00503438
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose CFZ533 in Rheumatoid Arthritis Patients
Novartis Pharmaceuticals
NCT02089087
FolateScan in Autoimmune Disease
Mayo Clinic
NCT00588393
Lipids, Inflammation, and CV Risk in RA
Brigham and Women's Hospital
NCT02714881
Safety and Tolerability Study Of PF-06835375 In Subjects With Seropositive Systemic Lupus Erythematosus Or Rheumatoid Arthritis
Pfizer
NCT03334851
Triple III Comparison of Leflunomide Alone Versus Two DMARD Combinations in the Treatment of Rheumatoid Arthritis
University of Nebraska
NCT00579878
A Multiple-dose Study of the Safety and Tolerability of REGN88(SAR153191) in Rheumatoid Arthritis Subjects
Regeneron Pharmaceuticals
NCT01011959
Effect of Exercise on the Disease Activity of Rheumatoid Arthritis
University of Nebraska
NCT00792675
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 33 |
| Phase 2 | 44 |
| Phase 3 | 25 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Rheumatoid Arthritis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Rheumatoid Arthritis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Rheumatoid Arthritis page
199 registered trials, 37 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 37 Rheumatoid Arthritis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Zimmer Biomet sponsors the most Rheumatoid Arthritis trials on record, review their full trial history before evaluating a specific study. See Zimmer Biomet's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Rheumatoid Arthritis condition card totals 199 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.