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ClinicalTrials.gov 37 recruiting now official registry

Rheumatoid Arthritis clinical trials

37 of 199 indexed Rheumatoid Arthritis trials are currently recruiting.

199 US clinical trials · 37 currently recruiting

Rheumatoid Arthritis is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 77 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 13 of these trials.

The research picture

Rheumatoid Arthritis has 199 registered US clinical trials, 37 of them open to new participants right now, about 19% of the total.

37
recruiting participants now
19%
of trials open to enrollment
32
in Phase 3–4 (later-stage)
13
top sponsor: Zimmer Biomet
Phase 133Phase 244Phase 325Phase 47

Active & Recent Trials

199 total, page 3 of 4

COMPLETED Phase 3 350 participants

Study to Assess the Safety and Efficacy of Modified-Release Prednisone (Lodotra®) Therapy in Patients With Active Rheumatoid Arthritis

Amgen

NCT00650078

COMPLETED Phase 2 300 participants

Effects of MEDI-522 On Disease Activity and Progression of Joint Damage in Patients With Active Rheumatoid Arthritis Suboptimally Responding to Methotrexate

MedImmune

NCT00069017

COMPLETED NA 286 participants

Enhancing Patient Ability to Understand and Utilize Complex Information Concerning Medication Self-management

University of North Carolina, Chapel Hill

NCT02820038

COMPLETED Phase 2 280 participants

Pain and Stress Management for People With Rheumatoid Arthritis

Wayne State University

NCT00088764

COMPLETED NA 273 participants

GIOP Prevention Among People With Rheumatoid Arthritis

University of North Carolina, Chapel Hill

NCT00609830

COMPLETED Phase 2 269 participants

Safety and Efficacy of Pf-06650833 In Subjects With Rheumatoid Arthritis, With An Inadequate Response To Methotrexate

Pfizer

NCT02996500

COMPLETED NA 266 participants

Actis Total Hip System 2 Year Follow-up

DePuy Orthopaedics

NCT02783274

COMPLETED Phase 2 266 participants

Study of the Effect of Fostamatinib Twice Daily on Blood Pressure in Patients With Rheumatoid Arthritis

AstraZeneca

NCT01563978

COMPLETED 265 participants

The Value of Orencia in Rapidly Progressing Rheumatoid Arthritis

Bristol-Myers Squibb

NCT03331393

COMPLETED Phase 2 260 participants

Study to Evaluate Efficacy, Safety and Tolerability of JTE-051 in Subjects With Active Rheumatoid Arthritis

Akros Pharma

NCT02919475

COMPLETED Phase 2 254 participants

Oral CF101 and Methotrexate Treatment in Rheumatoid Arthritis Patients

Can-Fite BioPharma

NCT00280917

COMPLETED Phase 2 251 participants

A Phase IIb Study for ALX-0061 Monotherapy in Subjects With Rheumatoid Arthritis

Ablynx, a Sanofi company

NCT02287922

COMPLETED Phase 2 232 participants

A Multicentre Trial to Determine the Efficacy of AD 452 in RA Subjects.

Sosei

NCT00141934

COMPLETED 231 participants

Post-PMA Approval Study: 10 Year Follow-Up IDE Subjects

Corin

NCT00721994

COMPLETED Phase 1 223 participants

Pharmacokinetic Study to Compare the Blood Levels of Abatacept Manufactured at Lonza Biologics to the Blood Levels of Abatacept Manufactured at the Devens, Massachusetts (MA) Facility of Bristol-Myers Squibb

Bristol-Myers Squibb

NCT01439204

COMPLETED Phase 2 221 participants

Efficacy and Safety of CDP6038 in Patients With Rheumatoid Arthritis With an Unsuccessful Response to Anti-Tumor Necrosis Factor (Anti-TNF) Therapy

UCB Pharma

NCT01242488

COMPLETED NA 210 participants

Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System

DePuy Orthopaedics

NCT00487565

COMPLETED Phase 2 204 participants

A Study of P38 Inhibitor (4) Monotherapy in Patients With Active Rheumatoid Arthritis

Hoffmann-La Roche

NCT00303563

COMPLETED NA 201 participants

Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology

Brigham and Women's Hospital

NCT05116163

COMPLETED 200 participants

Treatment Efficacy and Toxicity in Rheumatoid Arthritis Database and Repository

University of Alabama at Birmingham

NCT01070121

COMPLETED NA 200 participants

RAHelp.Org: An Online Self Management Program for Adults With Rheumatoid Arthritis

University of Missouri-Columbia

NCT00283855

COMPLETED Phase 2 189 participants

Treatment of Arthritis With Syk Kinase Inhibition (TASKI-1)

Rigel Pharmaceuticals

NCT00326339

COMPLETED NA 181 participants

ROSA Robot Used in Total Knee Replacement Post Market Study

Zimmer Biomet

NCT03969654

COMPLETED 162 participants

Perioperative Flare in RA: Characterization of Clinical and Biological Features

Hospital for Special Surgery, New York

NCT02111057

COMPLETED NA 160 participants

NexGen TM Tibia Clinical Outcomes Study

Zimmer Biomet

NCT03272373

COMPLETED Phase 2 157 participants

Treating Rheumatoid Arthritis With Tripterygium Wilfordi Hook F or Sulfasalazine

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT00062465

COMPLETED 149 participants

A Clinical Investigation of ArComXL® Polyethylene in Total Hip Replacement

Zimmer Biomet

NCT00698152

COMPLETED 142 participants

Protocol For The Quantitation Of Pain In The Diagnosis Of Polymyalgia Rheumatica

Lahey Clinic

NCT00847236

COMPLETED Phase 2 141 participants

The Study of Abatacept in Combination With Etanercept

Bristol-Myers Squibb

NCT00162279

COMPLETED Phase 2 134 participants

Impact of Literacy Level on Patient Education and Health Among People With Arthritis

Brigham and Women's Hospital

NCT00023205

COMPLETED Phase 2 127 participants

INCB028050 Compared to Background Therapy in Patients With Active Rheumatoid Arthritis (RA) With Inadequate Response to Disease Modifying Anti-Rheumatic Drugs

Incyte Corporation

NCT00902486

COMPLETED NA 125 participants

"Learning About Biologics"-Rheumatoid Arthritis

Geisinger Clinic

NCT01721200

COMPLETED NA 124 participants

Basket Study (CT-100-002) to Evaluate the Effects of a DiNaMo™ Component Training

Click Therapeutics

NCT05573685

COMPLETED Phase 2 119 participants

Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis

Bristol-Myers Squibb

NCT04186871

COMPLETED Phase 2 112 participants

A Study to Assess Immune Response Following Zoster Vaccination to Subjects With Rheumatoid Arthritis Receiving Tofacitinib or Placebo With Background Methotrexate

Pfizer

NCT02147587

COMPLETED NA 102 participants

2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use

Encore Medical, L.P.

NCT01284283

COMPLETED Phase 2 100 participants

A Phase 2 Study to Evaluate the Efficacy and Safety of 60mg of MM-093 in Patients With Active Rheumatoid Arthritis

Merrimack Pharmaceuticals

NCT00458146

COMPLETED NA 100 participants

Robotic Arm Assisted Total Knee Arthroplasty

MAKO Surgical

NCT02058069

COMPLETED Phase 2 88 participants

Study in Rheumatoid Arthritis for Subjects Who Completed Preceding Study M13-390 With Adalimumab

AbbVie (prior sponsor, Abbott)

NCT01752855

COMPLETED Phase 1 80 participants

Vaccination Study of Abatacept (BMS-188667) for Normal Healthy Volunteers

Bristol-Myers Squibb

NCT00279734

COMPLETED NA 79 participants

Living Well With Rheumatoid Arthritis

Brigham and Women's Hospital

NCT00869349

COMPLETED Phase 2 78 participants

Safety and Efficacy of Intravenous ACZ885 and Oral Methotrexate Therapy in Patients With Early Rheumatoid Arthritis

Novartis

NCT00487825

COMPLETED 76 participants

Ankle Joint Replacement Outcomes Study

Smith & Nephew

NCT00503438

COMPLETED Phase 1 75 participants

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose CFZ533 in Rheumatoid Arthritis Patients

Novartis Pharmaceuticals

NCT02089087

COMPLETED Phase 2 75 participants

FolateScan in Autoimmune Disease

Mayo Clinic

NCT00588393

COMPLETED 74 participants

Lipids, Inflammation, and CV Risk in RA

Brigham and Women's Hospital

NCT02714881

COMPLETED Phase 1 74 participants

Safety and Tolerability Study Of PF-06835375 In Subjects With Seropositive Systemic Lupus Erythematosus Or Rheumatoid Arthritis

Pfizer

NCT03334851

COMPLETED Phase 3 69 participants

Triple III Comparison of Leflunomide Alone Versus Two DMARD Combinations in the Treatment of Rheumatoid Arthritis

University of Nebraska

NCT00579878

COMPLETED Phase 1 60 participants

A Multiple-dose Study of the Safety and Tolerability of REGN88(SAR153191) in Rheumatoid Arthritis Subjects

Regeneron Pharmaceuticals

NCT01011959

COMPLETED NA 55 participants

Effect of Exercise on the Disease Activity of Rheumatoid Arthritis

University of Nebraska

NCT00792675

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Phase Distribution

PhaseTrial count
Phase 1 33
Phase 2 44
Phase 3 25
Phase 4 7

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Rheumatoid Arthritis Trial Landscape

199 indexed Rheumatoid Arthritis studies · 37 recruiting (19%).

Phase mix: 32 late (III/IV) vs 77 early (I/II).

Top sponsor: Zimmer Biomet (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Rheumatoid Arthritis?

PlainTrial tracks 199 US clinical trials for Rheumatoid Arthritis, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Rheumatoid Arthritis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.